53587-10-3

Basic information

• Product Name: HIPPURYL ACID CHLORIDE
• Synonyms: HIPPURYL ACID CHLORIDE;2-(Phenylformamido)acetyl chloride
• CAS NO: 53587-10-3
• Molecular Formula: C₉H₈ClNO₂
• Molecular Weight: 197.62
• Mol File: 53587-10-3.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: HIPPURYL ACID CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: HIPPURYL ACID CHLORIDE(53587-10-3)
• EPA Substance Registry System: HIPPURYL ACID CHLORIDE(53587-10-3)

Safety Data

• Hazardous Substances Data: 53587-10-3(Hazardous Substances Data)

Upstream product

• 495-69-2 Hippuric Acid 
• 10026-13-8 phosphorus pentachloride 
• 75-36-5 acetyl chloride 

Downstream Products

• 109506-26-5 1-hippuroyl-piperidine-2-carboxylic acid 
• 19811-58-6 benzoylamino-acetic acid benzyl ester 
• 58155-82-1 2-(benzoylamino-methyl)-6,8-dibromo-benzo[d][1,3]oxazin-4-one 
• 2113-93-1 3-acetyl-4-hydroxy-2,5-dihydropyrrol-2-one 
• 83544-54-1 Ethyl 4-(benzoylamino)-3-oxobutanoate 
• 859821-27-5 2,4-bis-benzoylamino-cyclobutane-1,3-dione 
• 83544-56-3 α-benzoylaminotetramic acid 
• 83544-55-2 1-benzoyl-3-(benzoylamino)-4-hydroxy-3-pyrrolin-2-one 
• 5813-81-0 hippuramide 
• 412017-27-7 N-(2-ethyl-2-hydroxy-butyl)-benzamide 
• 83544-52-9 ethyl hippurylmalonate 
• 861612-40-0 4-benzoylamino-2-cyano-acetoacetic acid ethyl ester 
• 38051-21-7 N,N'-dibenzoylpiperazine-2,5-dione 

Relevant articles and documents

2,5-diphenyl-oxazole preparation method

The invention relates to a method for preparing scintillation pure grade 2,5-diphenyl oxazole (DPO or PPO for short). The method comprises the following steps: by taking benzoyl glycine as a raw material, performing multiple steps of reaction such as acylating chlorination, Frieldel-Crafts and ring formation, purifying middle products of each step without being separated, and preparing 2,5-diphenyl oxazole by using a one-pot method. An obtained product can be rectified and purified, the requirements of a scintillator cannot be met but metal oxide heating treatment is needed, and thus a 2,5-diphenyl oxazole product for scintillation fluor can be obtained. As the one-pot method is adopted to prepare 2,5-diphenyl oxazole, the reaction steps are reduced, the operation process is simplified, the production efficiency is improved, a purification method is simple, convenient and effective, and on-scale industrialization production is achieved.

SYNTHESIS OF LUMINOPHORIC DERIVATIVES OF PBD BASED ON 2,5-DIARYL SUBSTITUTED THIAZOLES AND OXAZOLES

The Friedel-Crafts acylation of 2-(biphenyl-4-yl)-5-phenyl-1,3,4-oxadiazole (PBD) with hippuryl chloride has been used to prepare the derivative V which on cyclization with POCl3 or P4S10 gives the respective oxazole (or thiazole) derivative of PBD, XIa or XIb.The reaction of carboxylic acid II with 4-(ω-aminoacetyl)biphenyl in the presence of CDI gives N-acyl-α-aminoketone VII; the analogous compound VI has been prepared by acylating ω-aminoacetophenone with acyl chloride III.The cyclization of these compounds gives bifluorophores Xa - Xd.

Acylaminoacetyl Derivatives of Active Methylene Compounds. 1. The Cyclization of the Benzoylaminoacetyl Derivatives to α-Substituted Tetramic Acids (1)

Hippuric acid was converted to α-Y-substituted tetramic acids (Y = -CN, -CO2R and -COCH3) according to the following general scheme of reactions: a) preparation of the hippuric acid chloride or of its p-nitrophenyl ester; b) C-acylation of an active methy