5367-28-2

Basic information

• Product Name: 5-Chloro-2-nitrotoluene
• Synonyms: 1-chloro-3-methyl-4-nitro-benzen;5-chloro-2-nitro-toluen;Benzene, 4-chloro-2-methyl-1-nitro-;Toluene, 5-chloro-2-nitro-;4-CHLORO-2-METHYL-1-NITRO-BENZENE;5-CHLORO-2-NITROTOLUENE;3-chloro-6-nitrotoluene;2-Nitro-5-chlorotoluene
• CAS NO: 5367-28-2
• Molecular Formula: C₇H₆ClNO₂
• Molecular Weight: 171.58
• EINECS: 226-355-3
• Product Categories: Aromatic Hydrocarbons (substituted) & Derivatives;Nitro Compounds;Nitrogen Compounds;Organic Building Blocks
• Mol File: 5367-28-2.mol
• Article Data: 8

Chemical Properties

• Melting Point: 27-30 °C(lit.)
• Boiling Point: 124-126 °C (16 mmHg)
• Flash Point: 202 °F
• Appearance: clear yellow liquid
• Density: 1.32
• Vapor Pressure: 0.0372mmHg at 25°C
• Refractive Index: 1.57-1.572
• Storage Temp.: Inert atmosphere,Room Temperature
• Water Solubility: insoluble
• CAS DataBase Reference: 5-Chloro-2-nitrotoluene(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Chloro-2-nitrotoluene(5367-28-2)
• EPA Substance Registry System: 5-Chloro-2-nitrotoluene(5367-28-2)

Safety Data

• Hazard Codes: Xn,N
• Statements: 22-36-36/37/38-20/21/22-52/53
• Safety Statements: 26-36-36/37/39-61
• RIDADR: UN 3457 6.1/PG 3
• WGK Germany: 3
• RTECS: XS9134000
• HazardClass: 6.1
• PackingGroup: III
• Hazardous Substances Data: 5367-28-2(Hazardous Substances Data)

Usage

Chemical Properties

clear yellow liquid

General Description

The cytotoxicity of 5-chloro-2-nitrotoluene, an analog of chlorphenamidine, was studied.

InChI:InChI=1/C7H6ClNO2/c1-5-4-6(8)2-3-7(5)9(10)11/h2-4H,1H3

Upstream product

• 676-58-4 methylmagnesium chloride 
• 100-00-5 4-chlorobenzonitrile 
• 121-14-2 2,4-dinitrotoluene 
• 43192-03-6 4-hydroxylamino-2-nitrotoluene 
• 95-49-8 2-methylchlorobenzene 
• 95-69-2 4-chloro-2-methylbenzeneamine 
• 2028-72-0 m-toluenediazonium chloride 
• 108-41-8 1-chloro-3-methylbenzene 
• 7697-37-2 nitric acid 
• 611-05-2 4-nitro-3-methylaniline 
• 611-23-4 2-nitrosotoluene 

Downstream Products

• 2516-95-2 5-chloro-2-nitrobenzoic acid 
• 27144-23-6 5-Chloromethyl-1,3-diisopropyl-2-(3-methyl-4-nitro-phenoxy)-benzene 
• 27144-24-7 C₂₁H₂₅Cl₂NO₃ 
• 27144-25-8 C₂₃H₂₉Cl₂NO₃ 
• 95-69-2 4-chloro-2-methylbenzeneamine 
• 17422-32-1 5-chloro-1H-indole 
• 53827-86-4 3-Methyl-4-nitrophenyl-2-nitrophenylsulfid 
• 15138-28-0 2-(3'-Methyl-4'-nitrophenoxy)-1,3-diisopropylbenzol 
• 138334-78-8 2-[2-(5-Chloro-2-nitro-phenyl)-1-(2-methoxy-phenyl)-ethyl]-malonic acid dimethyl ester 
• 138334-77-7 2-[2-(5-Chloro-2-nitro-phenyl)-1-(3-methoxy-phenyl)-ethyl]-malonic acid dimethyl ester 
• 107966-98-3 [2-(5-chloro-2-nitrophenyl)-1-(4-methoxyphenyl)ethyl]propanedioic acid,dimethyl ester 
• 28291-52-3 C₁₄H₁₀Cl₂N₂O₄ 
• 31577-25-0 2-(bromomethyl)-4-chloro-1-nitrobenzene 
• 49828-63-9 C₁₆H₁₆ClNO₅S 

Relevant articles and documents

Nitration of deactivated aromatic compounds via mechanochemical reaction

A variety of deactivated arenes were nitrated to their corresponding nitro derivatives in excellent yields under high-speed ball milling condition using Fe(NO3)3·9H2O/P2O5 as nitrating reagent. A radical involved mechanism was proposed for this facial, eco-friendly, safe, and effective nitration reaction.

Highly efficient Sandmeyer reaction on immobilized CuI/CuII-based catalysts

Highly effective embodiment of Sandmeyer reaction has been revealed for Cu-based catalysts incorporating ionic liquid on Silochrom support. The most active catalyst (TOF = = 4000–8000 h–1) contains comparable amounts of cuprous and cupric chloride anions. The reported method allows one to carry out the reaction for anilines in the one-pot mode.

PYRAZOLO[1,5a]PYRIMIDINE DERIVATIVES AS IRAK4 MODULATORS

Compounds of the formula I or II: wherein X, m, Ar, R1 and R2 are as defined herein. The subject compounds are useful for treatment of IRAK-mediated conditions.