53673-01-1Relevant articles and documents
Imidazothiazole-based potent inhibitors of V600E-B-RAF kinase with promising anti-melanoma activity: biological and computational studies
Anbar, Hanan S.,El-Gamal, Mohammed I.,Jeon, Hong R.,Kwon, Dow,Lee, Bong S.,Oh, Chang-Hyun,Tarazi, Hamadeh
, p. 1712 - 1726 (2020/10/02)
A series of imidazothiazole derivatives possessing potential activity against melanoma cells were investigated for molecular mechanism of action. The target compounds were tested against V600E-B-RAF and RAF1 kinases. Compound 1zb is the most potent agains
New imidazo[2,1-b]thiazole derivatives: Synthesis, in vitro anticancer evaluation, and in silico studies
Park, Jin-Hun,El-Gamal, Mohammed I.,Lee, Yong Sup,Oh, Chang-Hyun
experimental part, p. 5769 - 5777 (2012/01/05)
A series of 18 new imidazo[2,1-b]thiazole derivatives was synthesized. Their in vitro antiproliferative activities against A375P human melanoma cell line and NCI-60 cell line panel were tested. Compounds 15, 16, 18, 22, 26-28, and 31 showed superior poten
SUBSTITUTED-AMINOHYDROXY-PROPOXY-THIADIAZOLES, BETA-BLOCKING COMPOSITIONS AND USE
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, (2008/06/13)
Novel substituted-aminohydroxypropoxy-thiadiazoles and pharmaceutically acceptable salts thereof exhibit β-adrenergic blocking activity.