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539-03-7

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539-03-7 Usage

Chemical Properties

white or greyish-beige crystalline powder

Uses

4'-Chloroacetanilide is used in pharmaceutical preparations, using PGC column. And also used in the synthesis of alprazolam.

Definition

ChEBI: Acetamide substituted on nitrogen by a para-chlorophenyl group.

General Description

4′-Chloroacetanilide is the main impurity present in acetaminophen and has been quantitated by new high-performance liquid chromatography method using a mixed-mode reversed-phase/cation exchange stationary phase.

Purification Methods

Crystallise the anilide from EtOH or aqueous EtOH. [Beilstein 12 IV 1178.]

Check Digit Verification of cas no

The CAS Registry Mumber 539-03-7 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 5,3 and 9 respectively; the second part has 2 digits, 0 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 539-03:
(5*5)+(4*3)+(3*9)+(2*0)+(1*3)=67
67 % 10 = 7
So 539-03-7 is a valid CAS Registry Number.

539-03-7 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
  • Packaging
  • Price
  • Detail
  • Alfa Aesar

  • (A11214)  4'-Chloroacetanilide, 98+%   

  • 539-03-7

  • 25g

  • 572.0CNY

  • Detail
  • Alfa Aesar

  • (A11214)  4'-Chloroacetanilide, 98+%   

  • 539-03-7

  • 100g

  • 1089.0CNY

  • Detail
  • Alfa Aesar

  • (A11214)  4'-Chloroacetanilide, 98+%   

  • 539-03-7

  • 500g

  • 4781.0CNY

  • Detail
  • Sigma-Aldrich

  • (PHR1149)  4-Chloroacetanilide (Acetaminophen RCJ)  pharmaceutical secondary standard

  • 539-03-7

  • PHR1149-1G

  • 804.73CNY

  • Detail
  • USP

  • (1003100)  Acetaminophen Related Compound J  United States Pharmacopeia (USP) Reference Standard

  • 539-03-7

  • 1003100-50MG

  • 13,501.80CNY

  • Detail
  • Aldrich

  • (158631)  4′-Chloroacetanilide  97%

  • 539-03-7

  • 158631-5G

  • 191.88CNY

  • Detail
  • Aldrich

  • (158631)  4′-Chloroacetanilide  97%

  • 539-03-7

  • 158631-25G

  • 423.54CNY

  • Detail

539-03-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 20, 2017

Revision Date: Aug 20, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-chloroacetanilide

1.2 Other means of identification

Product number -
Other names N-(4-Chlorophenyl)acetamide

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:539-03-7 SDS

539-03-7Relevant articles and documents

-

Mills

, (1862)

-

-

Southwick et al.

, p. 101,103 (1956)

-

Transamidation and Decarbonylation of N-Phthaloyl-Amino Acid Amides Enabled by Palladium-Catalyzed Selective C–N Bond Cleavage

Zhang, Hao-Yu,Tao, Xuan-Wen,Yi, Li-Na,Zhao, Zhi-Gang,Yang, Qiang

, p. 231 - 242 (2022/01/11)

Amides are important functional synthons that have been widely used in the construction of peptides, natural products, and drugs. The C–N bond cleavage provides the direct method for amide conversion. However, amides, especially secondary amides, tend to

Visible-light induced one-pot hydrogenation and amidation of nitroaromatics with carboxylic acids over 2D MXene-derived Pt/N-TiO2/Ti3C2

Jiang, Heyan,Hu, Zujie,Gan, Chuan,Sun, Bin,Kong, Shuzhen,Bian, Fengxia

, (2021/03/03)

Pt nanoparticles supported on N doped titanium dioxide/titanium carbide (MXene) heterojunctions were employed as photocatalysts for the tandem reactions between aromatic nitro compounds and carboxylic acids to produce amide products. The 3%Pt/N-TiO2/Ti3C2 heterojunction was prepared by in situ grew TiO2 on Ti3C2 nanosheets and then N doped TiO2 with melamine, Pt nanoparticles with 3.3 nm mean diameter well dispersed on N-TiO2/Ti3C2. 3%Pt/N-TiO2/Ti3C2 had excellent amidation activity and chemoselectivity under visible-light irradiation. The elevated catalytic performance of 3%Pt/N-TiO2/Ti3C2 was owing to the improvement in photogenerated electron and hole separation efficiency through charge short-range directional transmission caused by the intimate contact between the TiO2 and the conductive Ti3C2. This direct hydrogenation along with amidation between nitroaromatics and carboxylic acids own actual merits in the amides produce with no harmful byproducts. In situ DRIFTS spectra verified that the amidation activation with visible light irradiation at 25 °C was much faster than heating.

Nickel-Catalyzed Reductive Cross-Coupling of N-Acyl and N-Sulfonyl Benzotriazoles with Diverse Nitro Compounds: Rapid Access to Amides and Sulfonamides

Bai, Jin,Li, Shangzhang,Li, Wanfang,Qu, Erdong,Zheng, Yan

supporting information, (2021/12/27)

Herein we report a Ni-catalyzed reductive transamidation of conveniently available N-acyl benzotriazoles with alkyl, alkenyl, and aryl nitro compounds, which afforded various amides with good yields and a broad substrate scope. The same catalytic reaction conditions were also applicable for N-sulfonyl benzotriazoles, which could undergo smooth reductive coupling with nitroarenes and nitroalkanes to afford the corresponding sulfonamides.

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