539-44-6

Basic information

• Product Name: p-tolyl-hydrazin
• Synonyms: (4-methylphenyl)-hydrazin;4-Tolylhydrazine;p-tolyl-hydrazin
• CAS NO: 539-44-6
• Molecular Formula: C₇H₁₀N₂
• Molecular Weight: 122.1677
• EINECS: 208-717-2
• Mol File: 539-44-6.mol
• Article Data: 30

Chemical Properties

• Boiling Point: 242.8 °C at 760 mmHg
• Flash Point: 115.3 °C
• Appearance: /
• Density: 1.087 g/cm³
• Vapor Pressure: 0.0333mmHg at 25°C
• CAS DataBase Reference: p-tolyl-hydrazin(CAS DataBase Reference)
• NIST Chemistry Reference: p-tolyl-hydrazin(539-44-6)
• EPA Substance Registry System: p-tolyl-hydrazin(539-44-6)

Safety Data

• Statements: R20/21/22:Harmful by inhalation, in contact with skin and if swallowed.
• Safety Statements: S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.; S36:Wear suitable prot
• Hazardous Substances Data: 539-44-6(Hazardous Substances Data)

Usage

General Description

P-tolyl-hydrazine is a chemical compound with the formula C7H10N2. It is a colorless to pale yellow liquid with a strong odor, and it is highly flammable. P-tolyl-hydrazine is primarily used in the synthesis of pharmaceuticals and agrochemicals. It is also utilized in the manufacture of dyes, pigments, and other organic compounds. P-tolyl-hydrazine is known to be a hazardous substance, as it may cause skin and eye irritation upon contact, and prolonged exposure can lead to respiratory and nervous system effects. It is important to handle and store p-tolyl-hydrazine with care to prevent any potential health and safety risks.

InChI:InChI=1/C7H10N2.ClH/c1-6-2-4-7(9-8)5-3-6;/h2-5,9H,8H2,1H3;1H

Upstream product

• 108-88-3 toluene 
• 1972-28-7 diethylazodicarboxylate 
• 21988-82-9 4-oxo-3-p-tolyl-4,5-dihydro-[1,2,3]thiadiazolium betaine 
• 100-46-9 benzylamine 
• 35467-65-3 4-methylphenylhydrazine hydrochloride 
• 106-38-7 para-bromotoluene 
• 624-31-7 4-tolyl iodide 
• 106-43-4 para-chlorotoluene 
• 637-60-5 p-tolylhydrazine hydrochloride 
• 7647-01-0 hydrogenchloride 
• 53464-34-9 p-CH₃C₆H₄NNN(C₂H₅)C₆H₅ 
• 7664-93-9 sulfuric acid 
• 2028-84-4 p-methylbenzenediazonium chloride 
• 39479-55-5 sulfinyl-p-tolyl-hydrazine 

Downstream Products

• 109670-78-2 cyclohepta[b]quinoxalin-8-one-p-tolylhydrazone 
• 1858-99-7 benzaldehyde p-tolylhydrazone 
• 1026922-54-2 2-(p-methylphenyl)-4-phenylthiosemicarbazide 
• 89314-29-4 2-p-tolylhydrazono-propionic acid 
• 39479-55-5 sulfinyl-p-tolyl-hydrazine 
• 106166-31-8 4-nitro-2-p-tolyl-2H-benzotriazole 
• 106167-00-4 4-nitro-2-p-tolyl-2H-benzotriazole-1-oxide 
• 3352-86-1 1-p-tolylpyrazolidin-3-one 
• 42272-65-1 3-p-tolyl-carbazic acid methyl ester 
• 100-65-2 N-Phenylhydroxylamine 
• 5756-83-2 1-(4-methylphenyl)-3-phenyl-3-hydroxytriazene 
• 39771-53-4 oxalic acid ethyl ester-(N'-p-tolyl-hydrazide) 
• 110-21-4 hydrazodicarboxamide 
• 1077-21-0 acetone 4-methylphenylhydrazone 

Relevant articles and documents

Cross-Coupling between Hydrazine and Aryl Halides with Hydroxide Base at Low Loadings of Palladium by Rate-Determining Deprotonation of Bound Hydrazine

Reported here is the Pd-catalyzed C–N coupling of hydrazine with (hetero)aryl chlorides and bromides to form aryl hydrazines with catalyst loadings as low as 100 ppm of Pd and KOH as base. Mechanistic studies revealed two catalyst resting states: an arylpalladium(II) hydroxide and arylpalladium(II) chloride. These compounds are present in two interconnected catalytic cycles and react with hydrazine and base or hydrazine alone to give the product. The selectivity of the hydroxide complex with hydrazine to form aryl over diaryl hydrazine was lower than that of the chloride complex, as well as the catalytic reaction. In contrast, the selectivity of the chloride complex closely matched that of the catalytic reaction, indicating that the aryl hydrazine is derived from this complex. Kinetic studies showed that the coupling process occurs by rate-limiting deprotonation of a hydrazine-bound arylpalladium(II) chloride complex to give an arylpalladium(II) hydrazido complex.

1, 3, 4-oxadiazole hydrazide compound as well as preparation method and application thereof

The invention relates to a 1, 3, 4-oxadiazole hydrazide compound as well as a preparation method and application thereof. The compound has a structure as shown in a general formula (I), according to the invention, the method includes taking a 1, 3, 4-oxadiazole compound as a basis and introducing hydrazide into the system; the compound has a good inhibition effect on plant pathogenic bacteria, fungi and oomycetes, and has a good inhibition effect on pathogenic bacteria such as rice bacterial leaf blight, wheat scab, pepper fusarium wilt, sclerotinia sclerotiorum, colletotrichum gloeosporioides, phytophthora infestans, blueberry root rot and the like.

Lewis Acid Catalyzed Annulation of Cyclopropane Carbaldehydes and Aryl Hydrazines: Construction of Tetrahydropyridazines and Application Toward a One-Pot Synthesis of Hexahydropyrrolo[1,2- b]pyridazines

In this report, a facile synthesis of tetrahydropyridazines via a Lewis acid catalyzed annulation reaction of cyclopropane carbaldehydes and aryl hydrazines has been demonstrated. Moreover, the generated tetrahydropyridazine further participated in a cycloaddition reaction with donor-acceptor cyclopropanes to furnish hexahydropyrrolo[1,2-b]pyridazines. We also performed these two steps in one pot in a consecutive manner. In addition, a monodecarboxylation reaction of hexahydropyrrolo[1,2-b]pyridazine was achieved with a good yield.