54012-92-9 Usage
General Description
8-Amino-1,2,3,4-tetrahydroquinoline is a chemical compound with the molecular formula C9H11N. It is a heterocyclic compound that contains a quinoline ring with an amino group attached at the 8-position. 8-AMINO-1,2,3,4-TETRAHYDROQUINOLINE has been studied for its potential biological and pharmacological activities, such as its antimalarial and antibacterial properties. It has also been investigated as a potential building block for the synthesis of pharmaceutical compounds and as a ligand in coordination chemistry. Additionally, it has been evaluated for its potential use in organic electronic devices, such as organic light-emitting diodes (OLEDs) and organic photovoltaics.
Check Digit Verification of cas no
The CAS Registry Mumber 54012-92-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,4,0,1 and 2 respectively; the second part has 2 digits, 9 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 54012-92:
(7*5)+(6*4)+(5*0)+(4*1)+(3*2)+(2*9)+(1*2)=89
89 % 10 = 9
So 54012-92-9 is a valid CAS Registry Number.
InChI:InChI=1/C9H12N2/c10-8-5-1-3-7-4-2-6-11-9(7)8/h1,3,5,11H,2,4,6,10H2
54012-92-9Relevant articles and documents
Synthesis of 8-Aminoquinolines by Using Carbamate Reagents: Facile Installation and Deprotection of Practical Amidating Groups
Gwon, Donghyeon,Hwang, Heejun,Kim, Hye Kyung,Marder, Seth R.,Chang, Sukbok
, p. 17200 - 17204 (2016/01/25)
Described herein is the development of practical routes to 8-aminoquinolines by using readily installable and easily deprotectable amidating reagents. Two scalable procedures were optimized under RhIII-catalyzed conditions: i) the use of pre-generated chlorocarbamates and ii) a two-step one-pot process that directly employs carbamates. Both approaches are highly convenient for the gram-scale synthesis of 8-aminoquinolines under mild conditions. Facile deprotection of the synthetically versatile amidating groups was achieved under the Pd-catalyzed transfer hydrogenation conditions with simultaneous deoxygenation of quinoline N-oxides, thus yielding 8-aminoquinolines in excellent overall efficiency.
