540752-77-0

Basic information

• Product Name: 7-(3-chloromethyl-phenyl)-2-furan-2-yl-[1,2,4]triazolo[1,5-c]pyrimidin-5-ylamine
• CAS NO: 540752-77-0
• Molecular Weight: 325.757
• Mol File: 540752-77-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 7-(3-chloromethyl-phenyl)-2-furan-2-yl-[1,2,4]triazolo[1,5-c]pyrimidin-5-ylamine(CAS DataBase Reference)
• NIST Chemistry Reference: 7-(3-chloromethyl-phenyl)-2-furan-2-yl-[1,2,4]triazolo[1,5-c]pyrimidin-5-ylamine(540752-77-0)
• EPA Substance Registry System: 7-(3-chloromethyl-phenyl)-2-furan-2-yl-[1,2,4]triazolo[1,5-c]pyrimidin-5-ylamine(540752-77-0)

Safety Data

• Hazardous Substances Data: 540752-77-0(Hazardous Substances Data)

Upstream product

• 213896-64-1 7-chloro-2-(furan-2-yl)-[1,2,4]triazolo[1,5-c]pyrimidin-5-amine 
• 87199-15-3 [3-(hydroxymethyl)phenyl]boronic acid 
• 394652-85-8 furan-2-carboxylic acid N'-(2-amino-6-chloro-pyrimidin-4-yl)-hydrazide 
• 3326-71-4 2-furoic acid hydrazide 
• 862168-48-7 furan-2-carboxylic acid N'-[2-amino-6-(3-hydroxymethyl-phenyl)-pyrimidin-4-yl]-hydrazide 
• 540752-78-1 [3-(2-amino-6-chloro-pyrimidin-4-yl)-phenyl]-methanol 
• 540751-49-3 [3-(5-amino-2-furan-2-yl-[1,2,4]triazolo[1,5-c]pyrimidin-7-yl)-phenyl]-methanol 

Relevant articles and documents

2-(2-Furanyl)-7-phenyl[1,2,4]triazolo[1,5-c]pyrimidin-5-amine analogs: Highly potent, orally active, adenosine A2A antagonists. Part 1

The structure-activity relationship of this novel class of compounds based on 2-(2-furanyl)-7-phenyl[1,2,4]-triazolo[1,5-c]pyrimidin-5-amine, 1, and its analogs was evaluated for their in vitro and in vivo adenosine A2A receptor antagonism. Several compounds displayed oral activity at 3 mg/kg in a rat catalepsy model. Specifically, compound 8g displayed an excellent in vitro profile, as well as a highly promising in vivo profile.