5411-50-7

Basic information

• Product Name: NSC10978
• Synonyms: NSC10978;1,2-dibroMo-4-nitrobenzen;2-DIBROMO-4-NITROBENZENE
• CAS NO: 5411-50-7
• Molecular Formula: C₆H₃Br₂NO₂
• Molecular Weight: 280.903
• Mol File: 5411-50-7.mol
• Article Data: 13

Chemical Properties

• Melting Point: 58.5°C
• Boiling Point: 296°C (rough estimate)
• Appearance: /
• Density: 2.2414 (rough estimate)
• Refractive Index: 1.6400 (estimate)
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: NSC10978(CAS DataBase Reference)
• NIST Chemistry Reference: NSC10978(5411-50-7)
• EPA Substance Registry System: NSC10978(5411-50-7)

Safety Data

• Hazardous Substances Data: 5411-50-7(Hazardous Substances Data)

Usage

General Description

NSC10978 is a chemical compound that has been shown to have potential anticancer activity. It is a non-specific serine/threonine protein kinase inhibitor, meaning that it has the ability to inhibit the activity of multiple enzymes involved in cancer cell growth and survival. Research has demonstrated that NSC10978 can inhibit the growth of various cancer cell types, including colorectal, breast, and lung cancer cells. Furthermore, it has been found to induce cell cycle arrest and apoptosis in cancer cells, suggesting its potential as a therapeutic agent for the treatment of cancer. Further studies are needed to fully understand the mechanism of action and potential utility of NSC10978 in cancer treatment.

Upstream product

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Downstream Products

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Relevant articles and documents

meta-Nitration of Arenes Bearing ortho/para Directing Group(s) Using C?H Borylation

Herein, we report the meta-nitration of arenes bearing ortho/para directing group(s) using the iridium-catalyzed C?H borylation reaction followed by a newly developed copper(II)-catalyzed transformation of the crude aryl pinacol boronate esters into the corresponding nitroarenes in a one-pot fashion. This protocol allows the synthesis of meta-nitrated arenes that are tedious to prepare or require multistep synthesis using the existing methods. The reaction tolerates a wide array of ortho/para-directing groups, such as ?F, ?Cl, ?Br, ?CH3, ?Et, ?iPr ?OCH3, and ?OCF3. It also provides regioselective access to the nitro derivatives of π-electron-deficient heterocycles, such as pyridine and quinoline derivatives. The application of this method is demonstrated in the late-stage modification of complex molecules and also in the gram-scale preparation of an intermediate en route to the FDA-approved drug Nilotinib. Finally, we have shown that the nitro product obtained by this strategy can also be directly converted to the aniline or hindered amine through Baran's amination protocol.

PROCESS FOR THE PREPARATION OF ORGANIC BROMIDES

The present invention provides a process for the preparation of organic bromides, by a radical bromodecarboxylation of carboxylic acids with a bromoisocyanurate.

Synthesis and biological evaluation of piperazinyl heterocyclic antagonists of the gonadotropin releasing hormone (GnRH) receptor

Antagonism of the gonadotropin releasing hormone (GnRH) receptor has resulted in positive clinical results in reproductive tissue disorders such as endometriosis and prostate cancer. Following the recent discovery of orally active GnRH antagonists based on a 4-piperazinylbenzimidazole template, we sought to investigate the properties of heterocyclic isosteres of the benzimidazole template. We report here the synthesis and biological activity of eight novel scaffolds, including imidazopyridines, benzothiazoles and benzoxazoles. The 2-(4-tert-butylphenyl)-8-(piperazin-1-yl)imidazo[1,2-a]pyridine ring system was shown to have nanomolar binding potency at the human and rat GnRH receptors as well as functional antagonism in vitro. Additional structure-activity relationships within this series are reported along with a pharmacokinetic comparison to the benzimidazole-based lead molecule.