54231-32-2

Basic information

• Product Name: 3-Chloro-2-nitropyridine
• Synonyms: 3-CHLORO-2-NITROPYRIDINE;Chloro-2-nitropyridine;http://www.ruiyitech.com/detail.phpCAS=498572-74-0&class_id=4;3-CHLORO-2-NITROPYRIDINE 98%
• CAS NO: 54231-32-2
• Molecular Formula: C₅H₃ClN₂O₂
• Molecular Weight: 158.54
• EINECS: -0
• Product Categories: Pyridines, Pyrimidines, Purines and Pteredines;Pyridine series;Chloropyridines;Halopyridines;Halides;Pyridines;Heterocycle-Pyridine series
• Mol File: 54231-32-2.mol
• Article Data: 3

Chemical Properties

• Melting Point: 90-91°C
• Boiling Point: 279.051 °C at 760 mmHg
• Flash Point: 122.566 °C
• Appearance: white to pale yellow solid
• Density: 1.489 g/cm³
• Vapor Pressure: 0.00696mmHg at 25°C
• Refractive Index: 1.587
• Solubility: soluble in Methanol
• PKA: -4.87±0.22(Predicted)
• BRN: 1637069
• CAS DataBase Reference: 3-Chloro-2-nitropyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Chloro-2-nitropyridine(54231-32-2)
• EPA Substance Registry System: 3-Chloro-2-nitropyridine(54231-32-2)

Safety Data

• Hazard Codes: Xi,T
• Statements: 36/37/38-41-25
• Safety Statements: 26-36/37/39-36-45-39
• RIDADR: 2811
• PackingGroup: III
• Hazardous Substances Data: 54231-32-2(Hazardous Substances Data)

Usage

InChI:InChI=1/C5H3ClN2O2/c6-4-2-1-3-7-5(4)8(9)10/h1-3H

Upstream product

• 13269-19-7 3-amino-2-nitropyridine 

Downstream Products

• 17966-00-6 5H-pyrrolo<2,3-b:5,4-b'>dipyridine 
• 953045-28-8 1-benzoyl-3-(5-bromo-3-(phenylthio)pyridin-2-yl)thiourea 
• 953045-29-9 1-(5-bromo-3-(phenylthio)pyridin-2-yl)thiourea 
• 953045-27-7 5-bromo-3-(phenylthio)pyridin-2-amine 
• 42753-67-3 2-amino-3-ethylpyridine 
• 1309806-35-6 2-(4-bromophenyl)-1-{[(3S)-1-(cyclopropylcarbonyl)-3-pyrrolidinyl]methyl}-1H-imidazo[4,5-b]pyridine 
• 1404086-78-7 (S)-N-(1-(1-phenyl-1H-imidazo[4,5-b]pyridin-2-yl)propyl)-9H-purin-6-amine 
• 1404085-68-2 (S)-tert-butyl 1-oxo-1-(3-(phenylamino)pyridin-2-ylamino)butan-2-ylcarbamate 
• 1404085-69-3 (S)-1-(1-phenyl-1H-imidazo[4,5-b]pyridin-2-yl)propan-1-amine 
• 1393177-41-7 [(S)-1-(3-phenylaminopyridin-2-ylcarbamoyl)ethyl]carbamic acid tert-butyl ester 
• 54231-46-8 (2-nitro-pyridin-3-yl)-phenyl-amine 
• 1404085-63-7 (S)-N-(1-(1-Phenyl-1H-imidazo[4,5-b]pyridin-2-yl)ethyl)acetamide 
• 1404085-62-6 2-(chloromethyl)-1-phenyl-1H-imidazo[4,5-b]pyridine 
• 1404086-74-3 6-((1-phenyl-1H-imidazo[4,5-b]pyridin-2-yl)methylthio)-9H-purine 

Relevant articles and documents

Efficient transposition of the sandmeyer reaction from batch to continuous process

The transposition of Sandmeyer chlorination from a batch to a safe continuous-flow process was investigated. Our initial approach was to develop a cascade method using flow chemistry which involved the generation of a diazonium salt and its quenching with copper chloride. To achieve this safe continuous process diazotation, a chemometric approach (Simplex method) was used and extrapolated to establish a fully continuous-flow method. The reaction scope was also examined via the synthesis of several (het)aryl chlorides. Validation and scale-up of the process were also performed. A higher productivity was obtained with increased safety.

[2-[(Nitropyridinyl)amino]phenyl]arymethanones

[2-[(Nitropyridinyl)amino]phenyl]arylmethanones as chemical intermediates and/or having antidepressant activity having the formula: STR1 wherein: B is carbonyl, thioxomethyl, ketal or thioketal, R is hydrogen or -alk1 -Q, Q is hydrogen, --NR1 R2 or halogen are disclosed in a process for preparing pyrido[1,4]benzodiazepines.