5464-07-3

Basic information

• Product Name: 3-Acetoxy-2-naphthoic acid
• Synonyms: 3-Acetoxy-2-naphthoic acid
• CAS NO: 5464-07-3
• Molecular Formula: C₁₃H₁₀O₄
• Molecular Weight: 230.2161
• Mol File: 5464-07-3.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 394.9°Cat760mmHg
• Flash Point: 154°C
• Appearance: /
• Density: 1.325g/cm³
• Vapor Pressure: 6.03E-07mmHg at 25°C
• Refractive Index: 1.637
• CAS DataBase Reference: 3-Acetoxy-2-naphthoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Acetoxy-2-naphthoic acid(5464-07-3)
• EPA Substance Registry System: 3-Acetoxy-2-naphthoic acid(5464-07-3)

Safety Data

• Hazardous Substances Data: 5464-07-3(Hazardous Substances Data)

Usage

InChI:InChI=1/C13H10O4/c1-8(14)17-12-7-10-5-3-2-4-9(10)6-11(12)13(15)16/h2-7H,1H3,(H,15,16)

Upstream product

• 75-36-5 acetyl chloride 
• 92-70-6 3-Hydroxy-2-naphthoic acid 
• 108-24-7 acetic anhydride 

Downstream Products

• 142-26-7 2-acetylaminoethanol 
• 685-91-6 diethylacetamide 
• 1124-53-4 N-cyclohexylacetamide 
• 1119-49-9 N-butylacetamide 
• 79-16-3 N-methyl-acetamide 
• 54245-36-2 3-Ethoxy-2-naphthoesaeure 
• 673-49-4 N-acetylhistamine 
• 1224567-53-6 3-(3-tert-butoxycarbonylaminopropoxy)-N-(2-(3-tert-butoxycarbonyIaminopropoxy)-4-chlorophenyl)-2-naphthamide 
• 64-19-7 acetic acid 
• 92-70-6 3-Hydroxy-2-naphthoic acid 
• 1224567-54-7 N-(4-chloro-2-hydroxyphenyl)-3-hydroxy-2-naphthamide 
• 3665-51-8 3-hydroxy-2-naphthalenecarboxamide 
• 883-99-8 3-hydroxy-2-naphthoic acid methyl ester 
• 52449-77-1 3-hydroxy-2-naphthonitrile 

Relevant articles and documents

Importance of equilibrium fluctuations between most stable conformers in the control of the reaction mechanism

Hydrolysis of closely related compounds show how subtle structural differences markedly change reaction mechanisms. While in the hydrolysis of 3-acetoxy-2-naphthoic acid (3AC2NA) the reacting groups rotate freely, favoring intramolecular general base catalysis, the 1-acetoxy-2-naphthoic acid (1AC2NA) isomer is caged in an energy wall that freezes a conformation suitable for intramolecular nucleophilic attack, in contrast to the results expected for reactions governed largely by electronic effects. The results highlight the importance of the dynamics of equilibrium fluctuations between most stable conformers in the control of the reaction mechanism, (i) promoting the nucleophilic attack in 1AC2NA by allowing the most stable conformers to equilibrate only via rotation in a direction that intercepts the reaction coordinate and (ii) favoring a general base-catalyzed water attack in 3AC2NA by favoring equilibration via rotation that allows inclusion of a water molecule in a proper position for reaction.

4-Aminoarylguanidine and 4-aminobenzamidine derivatives as potent and selective urokinase-type plasminogen activator inhibitors

The structure-based design of potent and selective urokinase-type plasminogen activator (uPA) inhibitors with 4-aminoarylamidine or 4-aminoarylguanidine S1 binding groups, is described.

Thiazoline acid derivatives

Thiazoline acids and derivatives useful as chelators of trivalent metals in therapeutic applications have been prepared.