Welcome to LookChem.com Sign In|Join Free

Cas Database

5468-66-6

5468-66-6

Identification

  • Product Name:1H-Benzimidazole,2-[(4-chlorophenyl)methyl]-

  • CAS Number: 5468-66-6

  • EINECS:1308068-626-2

  • Molecular Weight:242.708

  • Molecular Formula: C14H11ClN2

  • HS Code:2933990090

  • Mol File:5468-66-6.mol

Synonyms:Benzimidazole,2-p-chlorobenzyl- (6CI);2-(p-Chlorobenzyl)benzimidazole;NSC 15003;

Post Buying Request Now
Entrust LookChem procurement to find high-quality suppliers faster

Safety information and MSDS view more

  • Pictogram(s):IrritantXi

  • Hazard Codes:Xi

  • Signal Word:no data available

  • Hazard Statement:no data available

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

  • Fire-fighting measures: Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

Supplier and reference price

  • Manufacture/Brand
  • Product Description
  • Packaging
  • Price
  • Delivery
  • Purchase
  • Manufacture/Brand:TRC
  • Product Description:2-(4-Chlorobenzyl)benzimidazole
  • Packaging:100mg
  • Price:$ 60
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:Matrix Scientific
  • Product Description:2-(4-Chlorobenzyl)-1H-benzimidazole
  • Packaging:500mg
  • Price:$ 95
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:Crysdot
  • Product Description:2-(4-Chlorobenzyl)benzimidazole 98%
  • Packaging:1000g
  • Price:$ 495
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:Crysdot
  • Product Description:2-(4-Chlorobenzyl)benzimidazole 98%
  • Packaging:500g
  • Price:$ 277
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:Chemenu
  • Product Description:2-(4-Chlorobenzyl)-1H-benzimidazole 98%
  • Packaging:500g
  • Price:$ 262
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:Chemenu
  • Product Description:2-(4-Chlorobenzyl)-1H-benzimidazole 98%
  • Packaging:1000g
  • Price:$ 468
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:Biosynth Carbosynth
  • Product Description:2-(4-Chlorobenzyl)-1H-benzimidazole
  • Packaging:500 mg
  • Price:$ 60
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:Biosynth Carbosynth
  • Product Description:2-(4-Chlorobenzyl)-1H-benzimidazole
  • Packaging:5 g
  • Price:$ 358
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:Biosynth Carbosynth
  • Product Description:2-(4-Chlorobenzyl)-1H-benzimidazole
  • Packaging:10 g
  • Price:$ 609
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:Biosynth Carbosynth
  • Product Description:2-(4-Chlorobenzyl)-1H-benzimidazole
  • Packaging:2 g
  • Price:$ 179
  • Delivery:In stock
  • Buy Now

Relevant articles and documentsAll total 7 Articles be found

Simple inorganic base promoted C-N and C-C formation: synthesis of benzo[4,5]imidazo[1,2-a]pyridines as functional AIEgens used for detecting picric acid

Yang, Kai,Luo, Shi-He,Chen, Si-Hong,Cao, Xi-Ying,Zhou, Yong-Jun,Lin, Yan-Lan,Huo, Yan-Ping,Wang, Zhao-Yang

supporting information, p. 8133 - 8139 (2021/10/04)

Metal-free catalyzed intermolecular tandem Michael addition/cyclization has been developed for the synthesis of benzo[4,5]imidazo[1,2-a]pyridines from α-bromocinnamaldehyde and 2-substituted benzimidazoles. The reaction promoted by a simple inorganic base displays moderate to good yields and good functional group tolerance. The optical properties of some typical products have been investigated. We found that, due to the presence of the benzene ring at the C1-position of benzo[4,5]imidazo[1,2-a]pyridines which restricts intramolecular motion, as a new type of aggregation-induced emission (AIE) luminogen (AIEgen), they show very good solid-state fluorescence with quantum yields up to 88.80%. Importantly, the AIE performance of compound3bcan be useful to detect the nitroaromatic explosive picric acid (PA) with a detection limit and quenching constant of 42.5 nM and 7.27 × 104M?M, respectively.

Synthesis method of benzimidazole derivative

-

Paragraph 0031, (2019/04/10)

The invention discloses a synthesis method of a benzimidazole derivative. The method comprises the following steps: o-phenylenediamine or a derivative thereof and phenylacetic acid or a derivative ofthe phenylacetic acid are used as raw materials, a composite solid catalyst is adopted, and a high-boiling-point organic solvent is taken as a reaction solvent for carrying out a reaction at 100-130 DEG C for 4-8 hours; and distillation, dissolution, neutralization, decoloration and recrystallization are carried out to obtain a benzimidazole derivative product. The method has the advantages that operation is simple, the reaction time is greatly shortened, the product color is good, the yield is high, cost is low, pollution is low, environment friendliness is achieved, and the like, and has a very good industrial production application prospect.

Dehydrogenative synthesis of benzimidazoles under mild conditions with supported iridium catalysts

Tateyama, Keisuke,Wada, Kenji,Miura, Hiroki,Hosokawa, Saburo,Abe, Ryu,Inoue, Masashi

, p. 1677 - 1684 (2016/04/05)

Solid supported iridium catalysts, which show excellent activity for the dehydrogenative synthesis of benzimidazoles from primary alcohols and phenylenediamine derivatives under mild reaction conditions, were developed. Among the catalysts examined, the titania-supported iridium catalyst showed the highest activity, and benzimidazole derivatives were selectively produced at temperatures of 80°C or higher. For example, the reaction of phenylenediamine (1a) with benzyl alcohol (2a) in the presence of Ir(1.0 wt%)/TiO2 (1.0 mol%, towards 1a) at 120°C selectively gave 2-phenylbenzimidazole (3aa) in 80% yield after 6 h and over 90% yield after 18 h. A high turnover number (TON) of more than 800 was achieved in the reaction at a higher substrate-to-catalyst ratio. Reduction of the catalysts under a hydrogen atmosphere at around 500 to 600°C is essential for their significant activity. Characterization of the catalysts by gas adsorption, XRD, XPS, H2-TPR, TEM, and XAFS techniques revealed that highly-dispersed nanoparticles of the iridium(0) species (ca. 1 to 2 nm in diameter) formed on TiO2 are responsible for the catalysis. The catalysts could be recycled without a significant loss of activity, and the leaching of the iridium species into the solution during the catalytic runs was negligible, which suggests that the present catalysts would be excellent from both environmental and practical perspectives.

2-substituted benzimidazole synthetic method of compound

-

Paragraph 0054; 0055; 0056, (2017/02/02)

The invention discloses a synthesis method of a 2-substituted benzimidazole compound. The method comprises the following steps: feeding an o-phenylenediamine compound and long-chain fatty acid or halogenated aromatic acid according to the molar ratio of 1

Exploration of 2-benzylbenzimidazole scaffold as novel inhibitor of NF-κB

Boggu, PullaReddy,Venkateswararao, Eeda,Manickam, Manoj,Kwak, Dajin,Kim, Youngsoo,Jung, Sang-Hun

, p. 1872 - 1878 (2016/04/05)

For finding the novel inhibitor of nuclear factor κB activity, a series of benzimidazole derivatives were rationally designed, synthesized and systematically studied for their in vitro activities against LPS induced NF-κB inhibition in RAW 264.7 cells using the SEAP assay based on the flexible chalcone JSH ((E)-1-(2-hydroxy-6-(isopentyloxy)phenyl)-3-(4-hydroxy phenyl)prop-2-en-1-one) which was previously reported. Although most of the benzimidazole derivatives showed strong inhibitory activity in low micromolar potency, 2-(4-methoxybenzyl)-1H-benzo[d]imidazole (3m; IC50 = 1.7 μM) and 2-(2-methoxybenzyl)-1H-benzo[d]imidazole (3n; IC50 = 2.4 μM) showed the best inhibition. The structure activity relationship revealed that 2-benzylbenzimidazole scaffold with hydrogen bonding acceptor on phenyl ring appears as a pharmacophore.

Process route upstream and downstream products

Process route

4-chlorophenylacetic Acid
1878-66-6

4-chlorophenylacetic Acid

1,2-diamino-benzene
95-54-5

1,2-diamino-benzene

2-(4-chlorobenzyl)-1H-benzo[d]imidazole
5468-66-6

2-(4-chlorobenzyl)-1H-benzo[d]imidazole

Conditions
Conditions Yield
4-chlorophenylacetic Acid; With sodium benzoate; at 110 ℃;
1,2-diamino-benzene; at 120 ℃; for 1h;
95%
In toluene; at 110 ℃; for 6.08333h;
88.2%
With boric acid; In 5,5-dimethyl-1,3-cyclohexadiene; for 16h; Reflux;
85%
With o-phenylenediamine dihydrochloride; at 200 ℃;
With hydrogenchloride; In water; Heating;
With hydrogenchloride; In water; for 6h; Reflux;
4-n-chlorophenylacetylene
873-73-4

4-n-chlorophenylacetylene

1,2-diamino-benzene
95-54-5

1,2-diamino-benzene

2-(4-chlorobenzyl)-1H-benzo[d]imidazole
5468-66-6

2-(4-chlorobenzyl)-1H-benzo[d]imidazole

Conditions
Conditions Yield
4-n-chlorophenylacetylene; 1,2-diamino-benzene; With copper(l) iodide; 4-toluenesulfonyl azide; triethylamine; In acetonitrile; at 20 ℃; for 6h; Inert atmosphere;
With sulfuric acid; In acetonitrile; for 4h; Reflux;
84%
2-(4-Chlorophenyl)ethanol
1875-88-3

2-(4-Chlorophenyl)ethanol

1,2-diamino-benzene
95-54-5

1,2-diamino-benzene

2-(4-chlorobenzyl)-1H-benzo[d]imidazole
5468-66-6

2-(4-chlorobenzyl)-1H-benzo[d]imidazole

Conditions
Conditions Yield
With 1,3,5-trimethyl-benzene; at 150 ℃; for 18h; Schlenk technique; Inert atmosphere;
> 99 %Chromat.
α-bromocinnamaldehyde
5443-49-2

α-bromocinnamaldehyde

2-(4-chlorobenzyl)-1H-benzo[d]imidazole
5468-66-6

2-(4-chlorobenzyl)-1H-benzo[d]imidazole

4-(4-chlorophenyl)-1-phenylbenzo[4,5]imidazo[1,2-a]pyridine

4-(4-chlorophenyl)-1-phenylbenzo[4,5]imidazo[1,2-a]pyridine

Conditions
Conditions Yield
With potassium carbonate; In N,N-dimethyl-formamide; at 120 ℃; for 12h;
93%
With potassium carbonate; In N,N-dimethyl-formamide; at 120 ℃; for 12h;
89%
2-(4-chlorobenzyl)-1H-benzo[d]imidazole
5468-66-6

2-(4-chlorobenzyl)-1H-benzo[d]imidazole

diethyl (bromodifluoromethyl)phosphonate
65094-22-6

diethyl (bromodifluoromethyl)phosphonate

2-(4-chlorobenzyl)-1-(difluoromethyl)-1H-benzo[d]imidazole

2-(4-chlorobenzyl)-1-(difluoromethyl)-1H-benzo[d]imidazole

Conditions
Conditions Yield
With potassium fluoride; In acetonitrile; at 20 ℃; for 12h; Schlenk technique; Inert atmosphere; Green chemistry;
92%
2-(4-chlorobenzyl)-1H-benzo[d]imidazole
5468-66-6

2-(4-chlorobenzyl)-1H-benzo[d]imidazole

methyl iodide
74-88-4

methyl iodide

2-(4-chlorobenzyl)-1-methyl-1H-benzo[d]imidazole
230313-64-1

2-(4-chlorobenzyl)-1-methyl-1H-benzo[d]imidazole

Conditions
Conditions Yield
With caesium carbonate; In tetrahydrofuran; at 60 ℃; for 6h; Sealed tube;
23%
2-(4-chlorobenzyl)-1H-benzo[d]imidazole
5468-66-6

2-(4-chlorobenzyl)-1H-benzo[d]imidazole

2-[2-(4-chlorobenzyl)-1H-benzimidazol-1-yl]acetohydrazide

2-[2-(4-chlorobenzyl)-1H-benzimidazol-1-yl]acetohydrazide

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1: potassium carbonate / acetone
2: hydrazine hydrate / ethanol / 6 h / Reflux
With potassium carbonate; hydrazine hydrate; In ethanol; acetone;
2-(4-chlorobenzyl)-1H-benzo[d]imidazole
5468-66-6

2-(4-chlorobenzyl)-1H-benzo[d]imidazole

2-[2-(4-chlorobenzyl)-1H-benzimidazol-1-yl]-N'-[(2-hydroxyphenyl)methylidene]acetohydrazide

2-[2-(4-chlorobenzyl)-1H-benzimidazol-1-yl]-N'-[(2-hydroxyphenyl)methylidene]acetohydrazide

Conditions
Conditions Yield
Multi-step reaction with 3 steps
1: potassium carbonate / acetone
2: hydrazine hydrate / ethanol / 6 h / Reflux
3: acetic acid / ethanol / 8 h / Reflux
With potassium carbonate; hydrazine hydrate; acetic acid; In ethanol; acetone;
2-(4-chlorobenzyl)-1H-benzo[d]imidazole
5468-66-6

2-(4-chlorobenzyl)-1H-benzo[d]imidazole

5-{[2-(4-chlorobenzyl)-1H-benzimidazol-1-yl]methyl}-1,3,4-oxadiazole-2-thiol

5-{[2-(4-chlorobenzyl)-1H-benzimidazol-1-yl]methyl}-1,3,4-oxadiazole-2-thiol

Conditions
Conditions Yield
Multi-step reaction with 3 steps
1: potassium carbonate / acetone
2: hydrazine hydrate / ethanol / 6 h / Reflux
3: potassium hydroxide / ethanol; water / 8 h / Reflux
With potassium carbonate; hydrazine hydrate; potassium hydroxide; In ethanol; water; acetone;
2-(4-chlorobenzyl)-1H-benzo[d]imidazole
5468-66-6

2-(4-chlorobenzyl)-1H-benzo[d]imidazole

4-(4-chlorophenyl)-1-(2-(2-phenyl-1H-benzimidazol-1-yl)acetyl)thiosemicarbazide

4-(4-chlorophenyl)-1-(2-(2-phenyl-1H-benzimidazol-1-yl)acetyl)thiosemicarbazide

Conditions
Conditions Yield
Multi-step reaction with 3 steps
1: potassium carbonate / acetone
2: hydrazine hydrate / ethanol / 6 h / Reflux
3: ethanol / 4 h / Reflux
With potassium carbonate; hydrazine hydrate; In ethanol; acetone;

Global suppliers and manufacturers

Global( 96) Suppliers
  • Company Name
  • Business Type
  • Contact Tel
  • Emails
  • Main Products
  • Country
  • SAGECHEM LIMITED
  • Business Type:Lab/Research institutions
  • Contact Tel:+86-571-86818502
  • Emails:will@sagechem.com
  • Main Products:28
  • Country:China (Mainland)
  • Simagchem Corporation
  • Business Type:Manufacturers
  • Contact Tel:+86-592-2680277
  • Emails:sale@simagchem.com
  • Main Products:110
  • Country:China (Mainland)
  • Hubei Vanz Pharm Co.,Ltd
  • Business Type:Manufacturers
  • Contact Tel:86-27-84492310
  • Emails:sales08@vanzpharm.com
  • Main Products:88
  • Country:China (Mainland)
  • Chemwill Asia Co., Ltd.
  • Business Type:Manufacturers
  • Contact Tel:021-51086038
  • Emails:sales@chemwill.com
  • Main Products:55
  • Country:China (Mainland)
  • Shaanxi BLOOM TECH Co.,Ltd
  • Business Type:Lab/Research institutions
  • Contact Tel:+86-29-86470566
  • Emails:sales@bloomtechz.com
  • Main Products:79
  • Country:China (Mainland)
  • Shanghai Upbio Tech Co.,Ltd
  • Business Type:Lab/Research institutions
  • Contact Tel:+86-21-52196435
  • Emails:upbiocn@hotmail.com
  • Main Products:88
  • Country:China (Mainland)
  • Hangzhou Ocean Chemical Co., Ltd.
  • Business Type:Lab/Research institutions
  • Contact Tel:+86-571-88025872, 28272092, 28272096
  • Emails:christina1618@hotmail.com
  • Main Products:70
  • Country:China (Mainland)
close
Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 5468-66-6
Post Buying Request Now
close
Remarks: The blank with*must be completed