5470-49-5

Basic information

• Product Name: 4-Methylsulfonylaniline
• Synonyms: -(Methylsulfonyl)aniline;Benzenamine, 4-(methylsulfonyl)-;niline, p-(methylsulfonyl)-;4-(METHYLSULPHONYL)ANILINE;4-(METHYLSULFONYL)ANILINE;4-METHYLSULFONYL-BENZENEAMINE;4-mesylaniline;BENZENEAMINE, 4-METHYLSULFONYL-
• CAS NO: 5470-49-5
• Molecular Formula: C₇H₉NO₂S
• Molecular Weight: 171.22
• EINECS: 226-803-8
• Mol File: 5470-49-5.mol
• Article Data: 41

Chemical Properties

• Melting Point: 243-245°C
• Boiling Point: 384.3 °C at 760 mmHg
• Flash Point: 186.2 °C
• Appearance: White/Crystalline Powder
• Density: 1.44
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Solubility: Chloroform (Slightly, Sonicated), Ethyl Acetate (Slightly, Sonicated)
• PKA: pK1:1.48(+1) (25°C)
• Water Solubility: Soluble in water.
• Sensitive: Light Sensitive
• CAS DataBase Reference: 4-Methylsulfonylaniline(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Methylsulfonylaniline(5470-49-5)
• EPA Substance Registry System: 4-Methylsulfonylaniline(5470-49-5)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-22
• Safety Statements: 22-24/25
• HazardClass: 6.1
• Hazardous Substances Data: 5470-49-5(Hazardous Substances Data)

Usage

Uses

It is used as pharmaceutical intermediate. A series of 4-(methylsulfonyl)aniline derivatives were synthesized in order to obtain new compounds as a potential anti-inflammatory agents with expected selectivity against COX-2 enzyme.

InChI:InChI=1/C7H9NO2S/c1-11(9,10)7-4-2-6(8)3-5-7/h2-5H,8H2,1H3

Upstream product

• 98-57-7 4-chlorophenyl methyl sulfone 
• 2976-30-9 1-methanesulfonyl-4-nitrobenzene 
• 473-27-8 4-(trifluoromethanesulfonyl)aniline 
• 75-16-1 methylmagnesium bromide 
• 20277-69-4 sodium methansulfinate 
• 540-37-4 p-aminoiodobenzene 
• 3466-32-8 4-bromoohenyl methyl sulfone 
• 106-47-8 4-chloro-aniline 
• 15898-43-8 sodium 4-acetamidobenzenesulfinate 
• 106-40-1 4-bromo-aniline 
• 104-96-1 4-methylsulfanylaniline 
• 130188-79-3 N-(4-((2-oxo-2-phenylethyl)sulfonyl)phenyl)acetamide 
• 74-88-4 methyl iodide 
• 3926-62-3 sodium monochloroacetic acid 

Downstream Products

• 17557-67-4 2-amino-6-(methylsulfonyl)benzothiazole 
• 64984-08-3 1-iodo-4-(methylsulfonyl)benzene 
• 22821-76-7 4-(methylsulfonyl)benzonitrile 
• 15863-56-6 1-isothiocyanato-4-methanesulfonyl-benzene 
• 177662-40-7 N-<4-(methylsulfonyl)phenyl>benzenecarboximidamide 
• 34392-62-6 sulfanilic acid-(4-methanesulfonyl-anilide) 
• 29209-05-0 2-methyl-1,1,3-trioxo-1,2,3,4-tetrahydro-1λ⁶-benzo[e][1,2]thiazine-4-carboxylic acid 4-methanesulfonyl-anilide 
• 76663-19-9 2-(4-Methanesulfonyl-phenylamino)-N-(4-sulfamoyl-phenyl)-acetamide 
• 52809-92-4 1--2-naphtol 
• 177662-27-0 3-chloro-4-methyl-N-[4-(methylsulfonyl)phenyl]benzenecarboximidamide 

Relevant articles and documents

COMPOSITES, METHODS AND USES THEREOF

The present invention relates, in general terms, to methods of catalysing a reaction, including the steps of contacting a chemical entity comprising a sulphide moiety with a composite and an oxidant. The composite acts as a heterogeneous catalyst to oxidise the sulphide moiety. The present invention also relates to composites, methods of synthesising the composites and its use as a catalyst thereof.

Hydroboration reduction reaction of aromatic nitro compounds without transition metal catalysis

The invention relates to a hydroboration reduction reaction of aromatic nitro compounds without transition metal catalysis. According to the method, triethyl boron and potassium tert-butoxide are used as catalysts for the first time, and an aromatic nitro compound and pinacol borane which is low in price and easy to obtain can be conveniently catalyzed to be subjected to a hydroboration reduction reaction under mild conditions to prepare aromatic amine products. Compared with a traditional method, the method generally has the advantages that the catalyst is cheap and easy to obtain, operation is convenient, and reaction is safe. The selective hydroboration reduction reaction of the non-transition metal reagent catalyzed aromatic nitro compound and pinacol borane is realized for the first time, and a practical new reaction strategy is provided for laboratory preparation or industrial production of aromatic amine products.

Cobalt Single-Atom-Intercalated Molybdenum Disulfide for Sulfide Oxidation with Exceptional Chemoselectivity

The identification of chemoselective oxidation process en route to fine chemicals and specialty chemicals is a long-standing pursuit in chemical synthesis. A vertically structured, cobalt single atom-intercalated molybdenum disulfide catalyst (Co1-in-MoS2) is developed for the chemoselective transformation of sulfides to sulfone derivatives. The single-atom encapsulation alters the electron structure of catalyst owing to confinement effect and strong metal–substrate interaction, thus enhancing adsorption of sulfides and chemoselective oxidation at the edge sites of MoS2 to achieve excellent yields of up to 99% for 34 examples. The synthetic scopes can be extended to sulfide-bearing alkenes, alkynes, aldehydes, ketones, boronic esters, and amines derivatives as a toolbox for the synthesis of high-value, multifunctional sulfones and late-stage functionalization of pharmaceuticals, e.g., Tamiflu. The synthetic utility of cobalt single atom-intercalated MoS2, together with its reusability, scalability, and simplified purification process, renders it promising for industrial productions.