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5472-99-1

5472-99-1

Identification

Synonyms:Anisole,3-chloro-2-nitro- (6CI); 1-Chloro-3-methoxy-2-nitrobenzene; NSC 29552

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Safety information and MSDS view more

  • Signal Word:no data available

  • Hazard Statement:no data available

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

  • Fire-fighting measures: Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

Supplier and reference price view more

  • Manufacture/Brand
  • Product Description
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  • Purchase
  • Manufacture/Brand:TRC
  • Product Description:1-Chloro-3-methoxy-2-nitrobenzene
  • Packaging:500mg
  • Price:$ 155
  • Delivery:In stock
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  • Manufacture/Brand:SynQuest Laboratories
  • Product Description:3-Chloro-2-nitroanisole
  • Packaging:5 g
  • Price:$ 752
  • Delivery:In stock
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  • Manufacture/Brand:SynQuest Laboratories
  • Product Description:3-Chloro-2-nitroanisole
  • Packaging:1 g
  • Price:$ 218
  • Delivery:In stock
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  • Manufacture/Brand:Crysdot
  • Product Description:1-Chloro-3-methoxy-2-nitrobenzene 95+%
  • Packaging:5g
  • Price:$ 314
  • Delivery:In stock
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  • Manufacture/Brand:Crysdot
  • Product Description:1-Chloro-3-methoxy-2-nitrobenzene 95+%
  • Packaging:10g
  • Price:$ 513
  • Delivery:In stock
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  • Manufacture/Brand:Chemenu
  • Product Description:1-chloro-3-methoxy-2-nitrobenzene 95%
  • Packaging:5g
  • Price:$ 294
  • Delivery:In stock
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  • Manufacture/Brand:Chemenu
  • Product Description:1-chloro-3-methoxy-2-nitrobenzene 95%
  • Packaging:10g
  • Price:$ 480
  • Delivery:In stock
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  • Manufacture/Brand:Chemcia Scientific
  • Product Description:1-Chloro-3-methoxy-2-nitro-benzene 97%
  • Packaging:1 G
  • Price:$ 78
  • Delivery:In stock
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  • Manufacture/Brand:Chemcia Scientific
  • Product Description:1-Chloro-3-methoxy-2-nitro-benzene 97%
  • Packaging:5 G
  • Price:$ 295
  • Delivery:In stock
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  • Manufacture/Brand:American Custom Chemicals Corporation
  • Product Description:1-CHLORO-3-METHOXY-2-NITROBENZENE 95.00%
  • Packaging:5MG
  • Price:$ 502.13
  • Delivery:In stock
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Relevant articles and documentsAll total 3 Articles be found

PYRAZOLE COMPOUNDS

-

Page/Page column 29, (2010/04/30)

The present invention relates to wherein each symbol is as defined in the specification. The compound has a superior mineralocorticoid receptor antagonistic action and is useful as an agent for the prophylaxis or treatment of a disease or condition mediated by the mineralocorticoid receptor activation.

Structure-activity relationship of a series of phenylureas linked to 4- phenylimidazole. Novel potent inhibitors of acyl-CoA:cholesterol O- acyltransferase with antiatherosclerotic activity. 2

Kimura,Watanabe,Matsui,Hayashi,Tanaka,Ohtsuka,Saeki,Kogushi,Kabayashi,Akasaka,Yamagishi,Saitou,Yamatsu

, p. 1641 - 1653 (2007/10/02)

In our continuing search to find systemically bioavailable ACAT (acyl- CoA:cholesterol O-acyl-transferase) inhibitors with more potent antiatherosclerotic effect than N-[2-(dimethylamino)-6-[3-(5-methyl-4- phenyl-1H-imidazol-1-yl)propoxy]phenyl]-N'-pentyl

Process route upstream and downstream products

Process route

3-methoxy-2-nitroaniline
16554-47-5

3-methoxy-2-nitroaniline

3-chloro-2-nitroanisole
5472-99-1

3-chloro-2-nitroanisole

Conditions
Conditions Yield
3-methoxy-2-nitroaniline; With hydrogenchloride; sodium nitrite; In water; at 0 ℃; for 1h;
With hydrogenchloride; copper dichloride; In water; at 0 - 20 ℃; for 48h;
66%
With hydrogenchloride; sulfuric acid; copper dichloride; sodium nitrite; Yield given. Multistep reaction; 1.) acetic acid, 10 deg C, 1 h, 2.) acetic acid, RT, 1 h;
2,6-dichloronitrobenzene
601-88-7

2,6-dichloronitrobenzene

sodium methylate
124-41-4

sodium methylate

3-chloro-2-nitroanisole
5472-99-1

3-chloro-2-nitroanisole

Conditions
Conditions Yield
With methanol; Kinetik dieser Reaktion bei 85grad und 110grad;
In methanol; for 18h; Reflux;
3-methoxy-2-nitrobenzoic acid
4920-80-3

3-methoxy-2-nitrobenzoic acid

3-chloro-2-nitroanisole
5472-99-1

3-chloro-2-nitroanisole

Conditions
Conditions Yield
Multi-step reaction with 3 steps
1: SOCl2
2: 1.) NaN3, 2.) H2O, 4.) NaOH, 5.) HCl
3: 1.) 98percent sulfuric acid, NaNO2, 2.) CuCl2, 36percent aq. HCl / 1.) acetic acid, 10 deg C, 1 h, 2.) acetic acid, RT, 1 h
With hydrogenchloride; sodium hydroxide; thionyl chloride; sodium azide; sulfuric acid; water; copper dichloride; sodium nitrite;
2-nitro-3-methoxybenzoyl chloride
15865-57-3

2-nitro-3-methoxybenzoyl chloride

3-chloro-2-nitroanisole
5472-99-1

3-chloro-2-nitroanisole

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1: 1.) NaN3, 2.) H2O, 4.) NaOH, 5.) HCl
2: 1.) 98percent sulfuric acid, NaNO2, 2.) CuCl2, 36percent aq. HCl / 1.) acetic acid, 10 deg C, 1 h, 2.) acetic acid, RT, 1 h
With hydrogenchloride; sodium hydroxide; sodium azide; sulfuric acid; water; copper dichloride; sodium nitrite;
2-nitro-3-chlorophenol
17802-02-7

2-nitro-3-chlorophenol

dimethyl sulfate
77-78-1

dimethyl sulfate

3-chloro-2-nitroanisole
5472-99-1

3-chloro-2-nitroanisole

Conditions
Conditions Yield
With sodium carbonate;
In acetone; Heating;
4-methoxy-2,3-dinitro-aniline
5473-00-7

4-methoxy-2,3-dinitro-aniline

3-chloro-2-nitroanisole
5472-99-1

3-chloro-2-nitroanisole

Conditions
Conditions Yield
With hydrogenchloride; Diazotization.Kochen des Chlordiazoniumsalzes mit Alkohol;
3-monochlorophenol
108-43-0

3-monochlorophenol

3-chloro-2-nitroanisole
5472-99-1

3-chloro-2-nitroanisole

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1: fuming sulfuric acid / man nitriert dann mit Salpetersaeure und rauchende Schwefelsaeure und destilliert mit Wasserdampf
2: natrium carbonate
With sulfuric acid; sodium carbonate;
4-methoxy-2-nitroacetanilide
119-81-3

4-methoxy-2-nitroacetanilide

3-chloro-2-nitroanisole
5472-99-1

3-chloro-2-nitroanisole

Conditions
Conditions Yield
Multi-step reaction with 3 steps
1: nitric acid
2: alcoholic NaOH-solution
3: HCl / Diazotization.Kochen des Chlordiazoniumsalzes mit Alkohol
With hydrogenchloride; sodium hydroxide; nitric acid;
acetic acid-(4-methoxy-2,3-dinitro-anilide)
62153-30-4

acetic acid-(4-methoxy-2,3-dinitro-anilide)

3-chloro-2-nitroanisole
5472-99-1

3-chloro-2-nitroanisole

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1: alcoholic NaOH-solution
2: HCl / Diazotization.Kochen des Chlordiazoniumsalzes mit Alkohol
With hydrogenchloride; sodium hydroxide;
4-methoxyacetanilide
51-66-1

4-methoxyacetanilide

3-chloro-2-nitroanisole
5472-99-1

3-chloro-2-nitroanisole

Conditions
Conditions Yield
Multi-step reaction with 3 steps
1: nitric acid
2: alcoholic NaOH-solution
3: HCl / Diazotization.Kochen des Chlordiazoniumsalzes mit Alkohol
With hydrogenchloride; sodium hydroxide; nitric acid;

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