54748-09-3

Basic information

• Product Name: 4-Pyrimidinamine, 2-chloro-5-nitro-N-phenyl-
• Synonyms: 2-chloro-5-nitro-N-phenyl-4-pyrimidinamine;4-Pyrimidinamine,2-chloro-5-nitro-N-phenyl;4-Anilino-2-chlor-5-nitropyrimidin;(2-chloro-5-nitro-pyrimidin-4-yl)-phenyl-amine;2-chloro-4-(N-phenyl)amino-5-nitropyrimidine;2-chloro-4-phenylamino-5-nitropyrimidine
• CAS NO: 54748-09-3
• Molecular Formula: C10H7ClN4O2
• Molecular Weight: 250.644
• Mol File: 54748-09-3.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 459.9±30.0 °C(Predicted)
• Density: 1.512±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 4-Pyrimidinamine, 2-chloro-5-nitro-N-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Pyrimidinamine, 2-chloro-5-nitro-N-phenyl-(54748-09-3)
• EPA Substance Registry System: 4-Pyrimidinamine, 2-chloro-5-nitro-N-phenyl-(54748-09-3)

Safety Data

• Hazardous Substances Data: 54748-09-3(Hazardous Substances Data)

Upstream product

• 62-53-3 aniline 
• 49845-33-2 2,4-Dichloro-5-nitropyrimidine 

Downstream Products

• 102495-66-9 5-nitro-N⁴-phenyl-pyrimidine-2,4-diyldiamine 
• 89660-19-5 2-chloro-N⁴-phenylpyrimidine-4,5-diamine 
• 89660-30-0 2-chloro-9-phenyl-7,9-dihydro-8H-purin-8-one 
• 89743-87-3 2-chloro-7-methyl-9-phenyl-7,9-dihydro-8H-purin-8-one 
• 1144044-97-2 N₂-cyclopropyl-5-nitro-N₄-phenylpyrimidine-2,4-diamine 
• 842129-20-8 intermediate 18 
• 1414781-16-0 C₂₈H₂₈N₈ 
• 842129-23-1 N²-(4-(4-methylpiperazin-1-yl)phenyl)-5-nitro-N⁴-phenylpyrimidine-2,4-diamine 

Relevant articles and documents

Pyrimido azacyclo compound and application thereof

The invention discloses a pyrimido azacyclo compound represented by a general formula I, and a pharmaceutically acceptable salt thereof, and relates to the technical field of organic chemistry, wherein substituent groups X and Ar are defined in the specification. The invention also relates to application of the compound represented by the general formula I and the pharmaceutically acceptable saltthereof in medicines for treating diseases caused by abnormal high expression of URAT1, particularly in preparation of medicines for treating and/or preventing gout, wherein the general formula I is defined in the specification.

The Discovery of 7-Methyl-2-[(7-methyl[1,2,4]triazolo[1,5- a]pyridin-6-yl)amino]-9-(tetrahydro-2 H-pyran-4-yl)-7,9-dihydro-8 H-purin-8-one (AZD7648), a Potent and Selective DNA-Dependent Protein Kinase (DNA-PK) Inhibitor

DNA-PK is a key component within the DNA damage response, as it is responsible for recognizing and repairing double-strand DNA breaks (DSBs) via non-homologous end joining. Historically it has been challenging to identify inhibitors of the DNA-PK catalyti

Synthesis and biological evaluation of pyrimidine derivatives as novel human Pin1 inhibitors

Pin1 (Protein interacting with NIMA1) is a cis–trans isomerase and promotes the amide bond rotation of phosphoSer/Thr-Pro motifs in its substrates. Inhibition of Pin1 might be a novel strategy for developing anticancer agents. Herein, a series of pyrimidi