54752-27-1Relevant articles and documents
Selectivity in the Aerobic Dearomatization of Phenols: Total Synthesis of Dehydronornuciferine by Chemo- and Regioselective Oxidation
Esguerra, Kenneth Virgel N.,Lumb, Jean-Philip
supporting information, p. 1514 - 1518 (2018/01/27)
We describe a selective aerobic oxidation of meta-biaryl phenols that enables rapid access to functionalized phenanthrenes. Aerobic oxidations attract interest due to their efficiency, but remain underutilized in complex molecule settings due to challenge
Synthesis and Characterization of New Heterocyclic Compounds Containing Thienylbenzo[h]Quinoline Moiety
Al-Taifi, Elham A.,Abbady, Mohamed S.,Bakhite, Etify A.
, p. 1479 - 1487 (2016/09/24)
In this paper the reaction of 2-(2′-thienylmethylene)-3,4-dihydronaphthalen-2(1H)-one (1) with cyanothioacetamide gave a mixture of 3-cyano-5,6-dihydro-4-(2′-thienyl)-benzo[h]quinolin-2(1H)-thione (2) and the related disulfide 3. Compound 2 was reacted with some halo compounds namely; ethyl chloroacetate, chloroacetamide, chloro(N-(p-chlorophenyl))acetamide, N1-chloroacetylsulfanilamide, and 2-chloromethyl-1H-benzimidazole to produce a series of 2-(substituted)methylthio-3-cyano-5,6-dihydro-4-(2′-thienyl)benzo[h]quinolines 4a, 4b, 4c, 4d, 4e and 11. Upon heating the latter compounds with sodium ethoxide, they underwent intramolecular Thorpe–Zeigler cyclization to furnish the corresponding 2-(substituted)-3-amino-5,6-dihydro-4-(2′-thienyl)-benzo[h]thieno[2,3-b]quinolines 5a, 5b, 5c, 5d, 5e and 12. (3-Cyano-5,6-dihydro-4-(2′-thienyl)-benzo[h]quinolin-2-ylthio)acethydrazide (8) and the related isomer, 3-amino-5,6-dihydro-4-(2′-thienyl)thieno[2,3-b]benzo[h]quinoline-2-carbohydrazide (9), were also synthesized. Most of the aforementioned compounds were used as key intermediates for synthesizing other benzo[h]quinolines, benzo[h]thieno[2,3-b]quinolines as well as benzo[h]pyrimido[4′,5′:4,5] thieno[2,3-b]quinolines. The structure of all synthesized compounds was confirmed by spectroscopic measurements and analytical analyses.
Synthesis, spectral analysis, X-ray crystal structures and evaluation of chemical reactivity of five new benzoindazole derivatives through experimental and theoretical studies
Taib, Layla A.,Faidallah, Hassan M.,?ahin, Zarife Sibel,Asiri, Abdullah M.,?ahin, Onur,Arshad, Muhammad Nadeem
, p. 272 - 279 (2015/01/08)
The main purpose of this study was synthesis, X-ray, DFT and spectroscopic investigations of the title compounds (I-V). Five new compounds were synthesized and the detailed experimental results are reported. The crystal and molecular structures of the tit
