54950-20-8

Basic information

• Product Name: Methyl nicotinoylacetate
• Synonyms: BUTTPARK 18\10-46;METHYL NICOTINOYLACETATE;beta-oxo-3-pyridinepropanoicacimethylester;3-Oxo-3-(3-pyridinyl)propionic acid methyl ester;3-Oxo-3-(3-pyridyl)propionic acid methyl ester;β-Oxo-3-pyridinepropanoic acid methyl ester;Methyl nicotinoylacetate,95%;Methyl ntcotinoylacetate
• CAS NO: 54950-20-8
• Molecular Formula: C₉H₉NO₃
• Molecular Weight: 179.17
• Mol File: 54950-20-8.mol
• Article Data: 14

Chemical Properties

• Melting Point: 34-42 °C
• Boiling Point: 283.1 °C at 760 mmHg
• Flash Point: 125 °C
• Appearance: White to yellow to brownish/Crystalline Powder, Crystals and/or Chunks
• Density: 1.189 g/cm³
• Vapor Pressure: 0.00323mmHg at 25°C
• Refractive Index: 1.514
• Storage Temp.: 2-8°C
• PKA: 9.45±0.46(Predicted)
• Water Solubility: neglegible
• CAS DataBase Reference: Methyl nicotinoylacetate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl nicotinoylacetate(54950-20-8)
• EPA Substance Registry System: Methyl nicotinoylacetate(54950-20-8)

Safety Data

• Hazard Codes: Xi
• Safety Statements: 24/25
• HazardClass: IRRITANT
• Hazardous Substances Data: 54950-20-8(Hazardous Substances Data)

Usage

Chemical Properties

white to pink-brownish crystalline powder

InChI:InChI=1/C9H9NO3/c1-13-9(12)5-8(11)7-3-2-4-10-6-7/h2-4,6H,5H2,1H3

Upstream product

• 350-03-8 methyl-3-pyridylketone 
• 616-38-6 carbonic acid dimethyl ester 
• 59-67-6 nicotinic acid 
• 38330-80-2 monomethyl monopotassium malonate 
• 75399-10-9 (Z)-3-Hydroxy-3-pyridin-3-yl-acrylic acid methyl ester 
• 93-60-7 methyl 3-pyridinecarboxylate 
• 79-20-9 acetic acid methyl ester 

Downstream Products

• 635325-89-2 4-[N'-(3-fluoro-phenyl)-hydrazino]-1-methyl-6-pyridin-3-yl-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid ethyl ester 
• 78584-30-2 methyl 3-(3-pyridinyl)-2-propynoate 
• 1268849-82-6 2-(3-(benzyloxy)phenyl)-6-(pyridin-3-yl)pyrimidin-4-ol 
• 56775-88-3 Zimelidine 
• 56775-89-4 (E)-3-(4-bromophenyl)-N,N-dimethyl-3-(3-pyridyl)allylamine 
• 77470-73-6 (Z)-3-(4-bromophenyl)-3-(3-pyridinyl)prop-2-en-1-ol 
• 91671-06-6 (E)-3-(4-bromophenyl)-3-(3-pyridinyl)prop-2-en-1-ol 
• 70263-44-4 (Z)-3-(4-bromophenyl)-3-(3-pyridyl) allyl chloride 
• 1426444-75-8 methyl 2-phenyl-5-(pyridin-3-yl)oxazole-4-carboxylate 
• 1426444-78-1 2-(2-phenyl-5-(pyridin-3-yl)oxazol-4-yl)acetonitrile 
• 1426444-77-0 4-(chloromethyl)-2-phenyl-5-(pyridin-3-yl)oxazole 
• 1426444-76-9 (2-phenyl-5-(pyridin-3-yl)oxazol-4-yl)methanol 

Relevant articles and documents

An Alternate Synthesis of Deethylvincadifformine

A synthesis of 20-deethylvincadifformine from methyl nicotinylacetate is described.The reaction scheme involved a fast construction of the pentacyclic nucleus of the Aspidosperma alkaloids and the early incorporation of the 16-carbomethoxy group common to these bases.

NEW ANALOGS AS ANDROGEN RECEPTOR AND GLUCOCORTICOID RECEPTOR MODULATORS

The present invention relates to novel dihydropyridine derivatives of formula (I): as modulators of nuclear receptors selected from androgen receptor and glucocorticoid receptor, to processes for their preparation, to pharmaceutical compositions comprising said compounds and to the use of said for manufacturing a medicament for the treatment of pathological conditions or diseases that can improve by modulation of androgen receptor and/or glucocorticoid receptor, selected from cancer, metastasizing cancers, benign prostate hyperplasia, polycystic ovary syndrome (PCOS), hair loss, hirsutism, acne, hypogonadism, muscle wasting diseases, cachexia, Cushing's syndrome, anti-psychotic drug induced weight gain, obesity, post-traumatic stress disorder and alcoholism.

COMPOUNDS

Provided are benzoxazolinone sulfonamide derivatives that inhibit Na v1.7 activity, pharmaceutical compositions containing them and their use in therapy for the treatment of diseases mediated by Na v1.7 activity.