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Cas Database

55096-26-9

55096-26-9

Identification

  • Product Name:Morphinan-3,14-diol,17-(cyclopropylmethyl)-4,5-epoxy-6-methylene-, (5a)-

  • CAS Number: 55096-26-9

  • EINECS:

  • Molecular Weight:339.434

  • Molecular Formula: C21H25NO3

  • HS Code:

  • Mol File:55096-26-9.mol

Synonyms:(-)-Nalmefene;6-Deoxo-6-methylenenaltrexone; 6-Desoxy-6-methylenenaltrexone; JF 1; Nalmefene;Nalmetrene; ORF 11676

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Safety information and MSDS view more

  • Pictogram(s):Xi

  • Hazard Codes:Xi

  • Signal Word:Warning

  • Hazard Statement:H315 Causes skin irritationH319 Causes serious eye irritation H335 May cause respiratory irritation

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

  • Fire-fighting measures: Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

Supplier and reference price

This product is a nationally controlled contraband, and the Lookchem platform doesn't provide relevant sales information.

Relevant articles and documentsAll total 4 Articles be found

Novel nalmefene dimer as well as preparation method and application thereof

-

Paragraph 0088-0090, (2021/10/13)

The invention relates to a novel nalmefene dimer compound with a structure as shown in a formula (I) or a salt thereof, and a preparation method and application of the compound, and the compound has a relatively strong inhibition effect on prostate cancer cell lines LNCaP and 22Rv1, and can be used for preparing drugs for resisting prostate cancer.

O-Demethylation of opioid derivatives with methane sulfonic acid/methionine: Application to the synthesis of naloxone and analogues

Andre,Dormoy,Heymes

, p. 2313 - 2327 (2007/10/02)

Naloxone 2 was obtained by demethylation of N-allylnoroxycodone 1 with methane sulfonic acid/methionine. This reagent is an excellent substitute for boron tribromide. It was used for the synthesis of analogous derivatives with variable results.

Wittig-reaction processes

-

, (2008/06/13)

Disclosed are improved Wittig reaction processes wherein the Wittig reaction is conducted in an anisole containing solvent.

Process for making 6-desoxy-6-methylenenaloxone and 6-desoxy-6-methylenenaltrexone

-

, (2008/06/13)

An improved Wittig reaction for making 6-desoxy-6-methylenenaloxone and 6-desoxy-6-methylenenaltrexone from naloxone and naltrexone utilizing an alkoxide base in an ethereal solvent.

Process route upstream and downstream products

Process route

Naltrexone
16590-41-3

Naltrexone

Methyltriphenylphosphonium bromide
1779-49-3

Methyltriphenylphosphonium bromide

Conditions
Conditions Yield
Multistep reaction; (i) NaH, DMSO, (ii) /BRN= 3596648/, (iii) aq. HCl;
Methyltriphenylphosphonium bromide; With potassium tert-butylate; In N,N-dimethyl-formamide; at 25 ℃; for 0.5h; Inert atmosphere;
Naltrexone; In N,N-dimethyl-formamide; at 25 ℃; for 1h; Inert atmosphere;
6.42 g
Conditions
Conditions Yield
With methanesulfonic acid; DL-methionine; at 40 ℃; for 24h;
Naltrexone
16590-41-3

Naltrexone

Methyltriphenylphosphonium bromide
1779-49-3

Methyltriphenylphosphonium bromide

Conditions
Conditions Yield
Multistep reaction; (i) NaH, DMSO, (ii) /BRN= 3596648/, (iii) aq. HCl;
Methyltriphenylphosphonium bromide; With potassium tert-butylate; In N,N-dimethyl-formamide; at 25 ℃; for 0.5h; Inert atmosphere;
Naltrexone; In N,N-dimethyl-formamide; at 25 ℃; for 1h; Inert atmosphere;
6.42 g
Conditions
Conditions Yield
With methanesulfonic acid; DL-methionine; at 40 ℃; for 24h;

Global suppliers and manufacturers

This product is a nationally controlled contraband, and the Lookchem platform doesn't provide relevant sales information.
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