55102-44-8

Basic information

• Product Name: Bofumustine
• Synonyms: Bofumustine;1-(2-Chloroethyl)-3-[5-O-(p-nitrobenzoyl)-2-O,3-O-isopropylidene-D-ribofuranosyl]-1-nitrosourea;ICIG-1105;N-(2-Chloroethyl)-N'-[2-O,3-O-(1-methylethylidene)-5-O-(4-nitrobenzoyl)-D-ribofuranosyl]-N-nitrosourea;Nsc279194;Urea, N-(2-chloroethyl)-N'-[2,3-o-(1-methylethylidene)-5-o-(4-nitrobenzoyl)-D-ribofuranosyl]-N-nitroso-
• CAS NO: 55102-44-8
• Molecular Formula: C18H21ClN4O9
• Molecular Weight: 472.88
• Mol File: 55102-44-8.mol
• Article Data: 1

Chemical Properties

• Melting Point: 101.5°C
• Boiling Point: 124.5°C (rough estimate)
• Flash Point: °C
• Appearance: /
• Density: 1.4868 (rough estimate)
• Refractive Index: 1.6000 (estimate)
• CAS DataBase Reference: Bofumustine(CAS DataBase Reference)
• NIST Chemistry Reference: Bofumustine(55102-44-8)
• EPA Substance Registry System: Bofumustine(55102-44-8)

Safety Data

• Hazardous Substances Data: 55102-44-8(Hazardous Substances Data)

Usage

Uses

Bofumustine is a nitrosourea containing compound with some antineoplastic property.

InChI:InChI=1/C18H21ClN4O9/c1-18(2)31-13-12(9-29-16(24)10-3-5-11(6-4-10)23(27)28)30-15(14(13)32-18)20-17(25)22(21-26)8-7-19/h3-6,12-15H,7-9H2,1-2H3,(H,20,25)

Upstream product

• 51172-55-5 p-toluenesulfonate d'amino-1, O-isopropylidene-2',3', α,β-D-ribofurannose 
• 122-04-3 4-nitro-benzoyl chloride 
• 96408-95-6 N-(chloro-2-ethyl)-N-nitrosocarbamate du trichloro-2,4,5 thiophenol 

Relevant articles and documents

Synthesis and evaluation of anti-tumor activity of nitrosoureas derived from amino-acids. II: Free aminoacids

The authors describe the synthesis of new nitosoureas of free amino-acids. On the basis of the NMR spectra the structures of these compounds were unambiguously assigned. The anti-tumor activity of these adducts towards L1210 was evaluated. A correlation b