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55110-99-1

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55110-99-1 Usage

General Description

2-(4-bromophenylamino)ethan-1-ol, also known as N-(4-bromophenyl)-2-hydroxyethylamine, is a chemical compound with the molecular formula C8H10BrNO. It is a primary amine and an alcohol, and it is used in the synthesis of pharmaceuticals and organic compounds. The compound is an off-white to light brown powder with a molecular weight of 214.07 g/mol. It is used as a reagent in organic chemistry for various reactions, including the formation of amides, esters, and other functional groups. The presence of the bromine and amino group in the compound makes it a versatile building block for the synthesis of complex organic molecules.

Check Digit Verification of cas no

The CAS Registry Mumber 55110-99-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,5,1,1 and 0 respectively; the second part has 2 digits, 9 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 55110-99:
(7*5)+(6*5)+(5*1)+(4*1)+(3*0)+(2*9)+(1*9)=101
101 % 10 = 1
So 55110-99-1 is a valid CAS Registry Number.

55110-99-1Relevant articles and documents

Room-Temperature Practical Copper-Catalyzed Amination of Aryl Iodides

Deldaele, Christopher,Evano, Gwilherm

, p. 1319 - 1328 (2016/04/20)

An efficient and highly practical procedure is reported for the Ullmann-Goldberg-type copper-catalyzed amination of aryl iodides. By using a combination of copper iodide and proline in the presence of an excess of an amine, a wide range of aryl iodides can be readily aminated at room temperature. The reaction proceeds well regardless of the electronic properties of the starting aryl iodide and the amination products can be obtained without the need for purification by column chromatography in most cases. Owing to its efficiency and the mildness of the reaction conditions, this amination could also be extended to the amination of complex aryl iodides at room temperature.

Highly Efficient Mechanochemical N-Arylation of Amino Alcohols and Diamines with Cu0 Powder

Martina, Katia,Rinaldi, Laura,Baricco, Francesca,Boffa, Luisa,Cravotto, Giancarlo

, p. 2789 - 2794 (2015/12/18)

Cu0-catalysed arylations have rightly acquired great importance over the last decade. This paper reports the N-arylation of amino alcohols and diamines with iodobenzene derivatives in a planetary ball mill and an investigation into the procedure. This newly developed solvent-free protocol is fast, efficient and occurs under the mechanochemical activation of metallic copper powder. It does not require additional ligands and gives excellent yields. This paper aims to broaden the scope of mechanochemical Cu0-activation and so a new one-pot, two-step synthesis that combines CuAAC and N-arylation has been successfully performed and reported herein.

Synthesis and biological evaluation of urea derivatives as highly potent and selective rho kinase inhibitors

Yin, Yan,Lin, Li,Ruiz, Claudia,Khan, Susan,Cameron, Michael D.,Grant, Wayne,Pocas, Jennifer,Eid, Nibal,Park, Hajeung,Schr?ter, Thomas,Lograsso, Philip V.,Feng, Yangbo

, p. 3568 - 3581 (2013/06/27)

RhoA and its downstream effector ROCK mediate stress fiber formation and cell contraction through their effects on the phosphorylation of myosin light chain (MLC). Inhibition of the RhoA/ROCK pathway has proven to be a promising strategy for several indications such as cardiovascular disease, glaucoma, and inflammatory disease. In 2010, our group reported urea-based ROCK inhibitors as potential antiglaucoma agents. These compounds showed potent IC50 values in enzymatic and cell-based assays and significant intraocular pressure (IOP)-lowering effects in rats (~7 mmHg).(22) To develop more advanced ROCK inhibitors targeting various potential applications (such as myocardial infarction, erectile dysfunction, multiple sclerosis, etc.) in addition to glaucoma, a thorough SAR for this urea-based scaffold was studied. The detailed optimization process, counter-screening, and in vitro and in vivo DMPK studies are discussed. Potent and selective ROCK inhibitors with various in vivo pharmacokinetic properties were discovered.

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