5518-62-7

Basic information

• Product Name: 1,2-BIS(PHOSPHINO)ETHANE
• Synonyms: BIS-PHOSPHINO ETHANE;1,2-BIS(PHOSPHINO)ETHANE;1,2-Bis(phosphino)ethane,99%;1,2-Bis(phosphanyl)ethane
• CAS NO: 5518-62-7
• Molecular Formula: C₂H₈P₂
• Molecular Weight: 94.03
• Product Categories: organophosphine ligand
• Mol File: 5518-62-7.mol
• Article Data: 4

Chemical Properties

• Melting Point: -62.4°C
• Boiling Point: 109-110°C
• Flash Point: 109-110°C
• Appearance: Colorless/Liquid
• Vapor Pressure: 7.21mmHg at 25°C
• Water Solubility: It is soluble in organic solvents. It is insoluble in water.
• Sensitive: Air Sensitive
• CAS DataBase Reference: 1,2-BIS(PHOSPHINO)ETHANE(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-BIS(PHOSPHINO)ETHANE(5518-62-7)
• EPA Substance Registry System: 1,2-BIS(PHOSPHINO)ETHANE(5518-62-7)

Safety Data

• Statements: 17-36/37/38
• Safety Statements: 17-36/37/39-45
• RIDADR: 2845
• HazardClass: 4.2
• PackingGroup: I
• Hazardous Substances Data: 5518-62-7(Hazardous Substances Data)

Usage

Uses

It is used in chemical research organic Intermediates.

InChI:InChI=1/C2H8P2/c3-1-2-4/h1-4H2

Upstream product

• 28240-69-9 1,2-bis(dichlorophosphino)ethane 
• 995-32-4 tetraethyl ethylenebis(phosphonate) 

Downstream Products

• 251459-19-5 1,2-bis[(2R,5R)-2,5-benzyloxymethylphospholanyl]ethane 
• 127502-06-1 Tetrofosmin 
• 28240-69-9 1,2-bis(dichlorophosphino)ethane 
• 437606-60-5 1,2-bis((1S,2R)-2-benzylphospholano)ethane 
• 136705-62-9 (+)-1,2-bis((2R,5R)-2,5-diethylphospholano)ethane 
• 136705-63-0 1,2-bis((2R,5R)-2,5-diisopropylphospholano)ethane 
• 136779-27-6 (S)-Et-BPE 
• 136779-26-5 1,2-bis((2S,5S)-2,5-dimethylphospholano)ethane 

Relevant articles and documents

In vitro antitumor activity of the water soluble copper(I) complexes bearing the tris(hydroxymethyl)phosphine ligand

Monocationic hydrophilic complexes [Cu(thp)4]+ 3 and [Cu(bhpe)2]+ 4 were synthesized by ligand exchange reactions starting from the labile [Cu(CH3CN)4][PF 6] precursor in the presence of an excess of the relevant hydrophilic phosphine. Complexes 3 and 4 were tested against a panel of several human tumor cell lines. Complex 3 has been shown to be about 1 order of magnitude more cytotoxic than cisplatin. Chemosensitivity tests performed on cisplatin and multidrug resistance phenotypes suggested that complex 3 acts via a different mechanism of action than the reference drug. Different short-term proliferation assays suggested that lysosomal damage is an early cellular event associated with complex 3 cytotoxicity, probably mediated by an increased production of reactive oxygen species. Cytological stains and flow cytometric analyses indicated that the phosphine copper(I) complex is able to inhibit the growth of tumor cells via G2/M cell cycle arrest and paraptosis accompanied with the loss of mitochondrial transmembrane potential.

Backbone-Modified Bisdiazaphospholanes for Regioselective Rhodium-Catalyzed Hydroformylation of Alkenes

A series of tetraaryl bisdiazaphospholane (BDP) ligands were prepared varying the phosphine bridge, backbone, and substituents in the 2- and 5-positions of the diazaphospholane ring. The parent acylhydrazine backbone was transformed to an alkylhydrazine via a borane reduction procedure. These reduced ligands contained an all sp3 hybridized ring mimicking the all sp3 phospholane of (R,R)-Ph-BPE, a highly selective ligand in asymmetric hydroformylation. The reduced bisdiazaphospholane (red-BDP) ligands were shown crystallographically to have an increased C-N-N-C torsion angle - this puckering resembles the structure of (R,R)-Ph-BPE and has a dramatic influence on regioselectivity in rhodium catalyzed hydroformylation. The red-BDPs demonstrated up to a 5-fold increase in selectivity for the branched aldehyde compared to the acylhydrazine parent ligands. This work demonstrates a facile procedure for increased branched selectivity from the highly active and accessible class of BDP ligands in hydroformylation.