55234-58-7

Basic information

• Product Name: 3-AMINO-PYRIDINE-2-CARBALDEHYDE
• Synonyms: 3-AMINO-PYRIDINE-2-CARBALDEHYDE;3-aminopicolinaldehyde;Zinc04352694;3-aMino-2-Pyridinecarboxaldehyde;2-Pyridinecarboxaldehyde, 3-amino-
• CAS NO: 55234-58-7
• Molecular Formula: C₆H₆N₂O
• Molecular Weight: 122.12
• Product Categories: Pyridine;Chemical Amines;Amines;Aromatics;Heterocycles;Miscellaneous Reagents
• Mol File: 55234-58-7.mol
• Article Data: 4

Chemical Properties

• Melting Point: 118-120°C
• Boiling Point: 302.638 °C at 760 mmHg
• Flash Point: 136.831 °C
• Appearance: /
• Density: 1.264 g/cm³
• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.652
• Storage Temp.: Refrigerator
• PKA: 4.68±0.10(Predicted)
• CAS DataBase Reference: 3-AMINO-PYRIDINE-2-CARBALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-AMINO-PYRIDINE-2-CARBALDEHYDE(55234-58-7)
• EPA Substance Registry System: 3-AMINO-PYRIDINE-2-CARBALDEHYDE(55234-58-7)

Safety Data

• Hazardous Substances Data: 55234-58-7(Hazardous Substances Data)

Usage

InChI:InChI=1/C6H6N2O/c7-5-2-1-3-8-6(5)4-9/h1-4H,7H2

Upstream product

• 116026-99-4 (2?formyl?pyridin?3?yl)?carbamic acid tert?butyl ester 
• 35905-85-2 2-bromonicotinic acid 
• 150281-83-7 2-ethenyl-3-nitropyridine 
• 5470-18-8 2-Chloro-3-nitropyridine 
• 10261-94-6 3-nitropyridine-2-carboxaldehyde 
• 27507-15-9 ethyl 3-aminopyridine-2-carboxylate 
• 52378-63-9 3-amino-2-hydroxy-methylpyridine 

Downstream Products

• 1312606-01-1 methyl (2-(2-(methylsulfonyl)phenyl)-1,5-naphthyridin-3-yl)methanol 
• 1312606-02-2 2-(1-(2-(2-(methylsulfonyl)phenyl)-1,5-naphthyridin-3-yl)ethyl)isoindoline-1,3-dione 
• 1609355-37-4 2-chloro-N-(4-chloro-3-(1,5-naphthyridin-2-yl)phenyl)-4-(3,3-dioxido-1,3,4-oxathiazinan-4-yl)benzamide 
• 1609355-28-3 C₂₅H₂₁ClN₄O₃S 
• 1609355-19-2 C₂₄H₁₉ClN₄O₃S 
• 1609355-81-8 4-chloro-3-(1,5-naphthyridin-2-yl)aniline 

Relevant articles and documents

Synthesis method of 3-aminopyridine formaldehyde

The invention discloses a synthesis method of 3-aminopyridine formaldehyde, which comprises the following steps of: carrying out a cutius rearrangement reaction on 2-bromonicotinic acid serving as a raw material to obtain tert-butyl (2-bromopyridine-3-yl) carbamate, carrying out a Grignard reaction to obtain tert-butyl (2-formyl pyridine-3-yl) carbamate, and finally carrying out a hydrolysis reaction to obtain 3-aminopyridine formaldehyde. The synthesis method overcomes the defects of expensive raw materials, low yield, use of microwave reaction and other conditions, difficulty in amplification and the like in the existing synthesis process, and has the advantages of simple synthesis route, reasonable process selection, low raw material cost, simple and easily available raw materials, convenience in operation and post-treatment, high total yield, no use of highly toxic reagents, easiness in amplification, and realization of mass production.

HETEROCYCLIC COMPOUNDS AND THEIR USES

Substituted bicyclic heteroaryls and compositions containing them, for the treatment of general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, including but not restricted to autoimmune diseases such as systemic lupus erythematosis (SLE), myestenia gravis, rheumatoid arthritis, acute disseminated encephalomyelitis, idiopathic thrombocytopenic purpura, multiples sclerosis, Sjoegren's syndrome and autoimmune hemolytic anemia, allergic conditions including all forms of hypersensitivity, The present invention also enables methods for treating cancers that are mediated, dependent on or associated with p110δ activity, including but not restricted to leukemias, such as Acute Myeloid leukaemia (AML) Myelo-dysplastic syndrome (MDS) myelo-proliferative diseases (MPD) Chronic Myeloid Leukemia (CML) T-cell Acute Lymphoblastic leukaemia (T-ALL) B-cell Acute Lymphoblastic leukaemia (B-ALL) Non Hodgkins Lymphoma (NHL) B-cell lymphoma and solid tumors, such as breast cancer.