5534-13-4Relevant articles and documents
Preparation method of betamethasone 17 alpha-propionate
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Paragraph 0011; 0012; 0014; 0016; 0017, (2019/08/20)
The invention provides a preparation method of betamethasone 17 alpha-propionate. According to the preparation method, betamethasone is subjected to a reaction with triethyl orthopropionate, the reaction is performed in a tetrahydrofuran solvent, further, p-toluenesulfonic acid is adopted as a catalyst, after the reaction is finished, an aluminum trichloride solution is dropwise added to the samesolvent system directly without discharging, a thermal insulation reaction is performed after the solution is dropwise added, and betamethasone 17 alpha-propionate is obtained with a post-treatment process. According to the preparation method of betamethasone 17 alpha-propionate, preparation process is simplified, yield is increased and purity is improved while the problem that dioxane, dimethylformamide or another solvent is adopted as the reaction solvent of betamethasone 17 alpha-propionate is solved.
Composition for the topical treatment of poison ivy and other forms of contact dermatitis
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, (2008/06/13)
Composition for topical administration comprising (a) a corticosteroid, and (b) a drying agent.
An improved synthesis of corticosteroid 17α-esters by synthetic aluminium silicate-mediated conversion of 17α, 21-cyclic ortho esters
Sugai,Okazaki,Akaboshi
, p. 700 - 701 (2007/10/02)
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