55386-67-9

Basic information

• Product Name: 6-methyl-2,3,4,5-tetrahydropyridine 1-oxide
• CAS NO: 55386-67-9
• Molecular Formula: C₆H₁₁NO
• Molecular Weight: 113.1576
• Mol File: 55386-67-9.mol
• Article Data: 23

Chemical Properties

• Boiling Point: 209.1°C at 760 mmHg
• Flash Point: 89.7°C
• Density: 0.96g/cm³
• Vapor Pressure: 0.298mmHg at 25°C
• Refractive Index: 1.477
• CAS DataBase Reference: 6-methyl-2,3,4,5-tetrahydropyridine 1-oxide(CAS DataBase Reference)
• NIST Chemistry Reference: 6-methyl-2,3,4,5-tetrahydropyridine 1-oxide(55386-67-9)
• EPA Substance Registry System: 6-methyl-2,3,4,5-tetrahydropyridine 1-oxide(55386-67-9)

Safety Data

• Hazardous Substances Data: 55386-67-9(Hazardous Substances Data)

Usage

General Description

6-methyl-2,3,4,5-tetrahydropyridine 1-oxide, also known as MPTP, is a synthetic compound that is not found naturally in the environment. It is structurally similar to the neurotransmitter dopamine and has been used to induce Parkinson's disease-like symptoms in animal models for research purposes. MPTP's mechanism of action involves its conversion to a toxic metabolite called MPP+ in the brain, which selectively damages dopamine-producing neurons. This results in the characteristic motor symptoms of Parkinson's disease, making MPTP a valuable tool for studying the underlying causes of the disorder and developing potential treatments. However, MPTP is highly toxic to humans and exposure can lead to severe neurological damage, highlighting the need for careful handling and regulation of this hazardous chemical.

Upstream product

• 109-05-7 2-Methylpiperidin 
• 10226-30-9 6-chloro-2-hexanone 
• 99687-80-6 2-methyl-1-hydroxypiperidine 
• 80-62-6 methacrylic acid methyl ester 

Downstream Products

• 124525-95-7 (3R,3aS)-3-Benzenesulfonyl-3a-methyl-hexahydro-isoxazolo[2,3-a]pyridine 
• 132235-41-7 (1'R,2S,2'S,5'R)-1-<(2-isopropyl-5-methylcyclohexyl)oxymethoxy>-2-methyl-2-piperidine carboxamide 
• 132235-39-3 (1'R,2R,2'S,5'R)-1-<(2-isopropyl-5-methylcyclohexyl)oxymethoxy>-2-methyl-2-piperidine carboxamide 
• 105141-61-5 (R)-2-methyl-2-piperidinecarboxylic acid 
• 89115-95-7 (S)-2-Methyl-2-piperidinecarboxylic acid 
• 132259-55-3 (2R)-2-methyl-2-piperidinecarboxamide 
• 132235-44-0 (2S)-2-methyl-2-piperidinecarboxamide 
• 355019-38-4 3-[buta-1(E),3-dienyl]-3a-methyl-2-phenyl-4,5,6,7-tetrahydro-3aH-isoxazolo[2,3-a]pyridine 
• 155371-20-3 3a-methyl-2-phenyl-4,5,6,7-tetrahydro-3aH-isoxazolo[2,3-a]pyridine-3-carbaldehyde 
• 109-05-7 2-Methylpiperidin 
• 132235-37-1 (1'R,2S,2'S,5'R)-1-<(2-isopropyl-5-methylcyclohexyl)oxymethoxy>-2-methyl-2-piperidinecarbonitrile 
• 132235-35-9 (1'R,2R,2'S,5'R)-1-<(2-isopropyl-5-methylcyclohexyl)oxymethoxy>-2-methyl-2-piperidinecarbonitrile 
• 124525-91-3 (3aR,3bS,8aS)-3b-Methyl-2-phenyl-hexahydro-8-oxa-2,7a-diaza-cyclopenta[a]indene-1,3-dione 
• 127983-46-4 cis-6-methyl-8-phenyl-9-oxa-1-azabicyclo<4.3.0>nonane 

Relevant articles and documents

Strain-Release Driven Cycloadditions for Rapid Construction of Functionalized Pyridines and Amino Alcohols

This paper describes the development of a new variant of stereoselective strain-release driven reactions (formal homo [3 + 2] dipolar cycloadditions) which utilize housane (1) to construct functionalized amino alcohols and pyridine-substituted cyclopentanes in two to three steps from simple and easily available building blocks (nitrones and pyridine N-oxides respectively).

Molybdenum oxide/bipyridine hybrid material {[MoO3(bipy)] [MoO3(H2O)]}n as catalyst for the oxidation of secondary amines to nitrones

The inorganic-organic hybrid material {[MoO3(bipy)][MoO 3(H2O)]}n (bipy = 2,2′-bipyridine) can be used as a water-tolerant catalyst for the oxidation of secondary amines under mild conditions using either urea hydrogen peroxide (UHP) or tert-butylhydroperoxide (TBHP) as the oxidant. Under optimized reaction conditions (2 mol % catalyst, 3-4 equiv TBHP, CH2Cl2 as the solvent, 40 °C), the corresponding nitrones were obtained with different efficiency depending on the nature of the cyclic or acyclic amine used.

Process for the preparation of amine oxides

The present invention provides a process for the preparation of amine oxide by reacting a tertiary or a secondary amine with hydrogen peroxide as an oxidant in the presence of a recyclable heterogeneous catalyst comprising a layered double hydroxide exchanged with an anion in the presence of an additive selected from the group consisting of benzonitrile, propionitrile, isoburyronitrile, benzamide and isobutyramide.