55481-88-4Relevant articles and documents
Synthesis of novel and diverse mollugin analogues and their antibacterial and antioxidant activities
Idhayadhulla, Akber,Xia, Likai,Lee, Yong Rok,Kim, Sung Hong,Wee, Young-Jung,Lee, Chong-Soon
, p. 77 - 82 (2014)
Novel and diverse mollugin analogues (1-12) were synthesized using PhB(OH)2/AcOH-mediated electrocyclization reaction as a key step. The newly synthesized compounds were screened for antioxidant and antibacterial activities. Compounds 1, 2, 5, 6, 8, and 10-12 showed high antioxidant activities in DPPH inhibition (IC50 = 0.52-1.11 μM) compared with BHT (IC50 = 9.67 μM). Compounds 3 exhibited potent antibacterial activity against Staphylococcus aureus (KCTC-1916) bacterial strain at 100 μg/mL. Structures of newly synthesized compounds were confirmed by IR, 1H NMR, 13C NMR data and high-resolution mass spectrometry.
CF3-substituted mollugin 2-(4-morpholinyl)-ethyl ester as a potential anti-inflammatory agent with improved aqueous solubility and metabolic stability
Hong, Ki Bum,Kim, Darong,Kim, Bo-Kyung,Woo, Seo Yeon,Lee, Ji Hoon,Han, Seung-Hee,Bae, Gyu-Un,Kang, Soosung
, (2018/09/26)
Although mollugin, the main ingredient of the oriental medicinal herb Rubia cordifolia, has considerable anti-inflammatory effects, it has poor aqueous solubility as well as poor metabolic and plasma stability. To overcome these shortfalls, various mollug
Asymmetric epoxidation of chromenes mediated by iminium salts: Synthesis of mollugin and (3S,4R)-trans-3,4-dihydroxy-3,4-dihydromollugin
Bulman Page, Philip C.,Chan, Yohan,Noor Armylisas, Abu Hassan,Alahmdi, Mohammed
, p. 8406 - 8416 (2016/12/06)
Organocatalytic asymmetric epoxidation of chromenes mediated by iminium salt catalysts under non-aqueous conditions provided ees as high as 99%. Contrastingly, reaction under aqueous conditions can form the corresponding diol products with ees as high as 71%. The process has been used for the synthesis of the East African medicinal plant metabolite (3S,4R)-trans-3,4-dihydroxy-3,4-dihydromollugin.
Facile synthesis of mollugin by kinetic control and anti-HCV (Hepatitis C Virus) activity of its analogues
Choi, Da Hye,Lee, Na Ri,Kim, Cheol Gi,Kim, Jong Woo,Lee, Sang Wook,Jun, Jong-Gab
, p. 3232 - 3238 (2015/04/22)
Mollugin has been reported to have various biological activities including antineoplastic, antitumor, antiviral against the hepatitis B virus, anti-aging and antimutagenic activities. An effective and concise synthesis of mollugin in two steps including kinetic control from the cheap starting material 1,4-naphthoquinone has been introduced, and mollugin derivatives thus prepared are screened for their inhibition ability against the hepatitis C virus (HCV) and the dihydrobenzochromene structure might be an additional anti-HCV agent as a new leading compound.