555-77-1 Usage
Chemical Properties
HN-3, a nitrogen mustard blister agent (vesicants,
is a colorless to pale yellow liquid. Pure material is
odorless; otherwise, it has a faint fish-or soap-like odor.
General Description
Liquid with faint odor of fish and soap, no odor when pure. Used as a delayed-action casualty military agent.
Air & Water Reactions
Acts as a strong base in water.
Reactivity Profile
When dissolved in water, TRIS-(2-CHLOROETHYL)-AMINE is a strong base; reacts violently with strong oxidants and acids ; attacks copper and copper compounds. [Handling Chemicals Safely 1980. p. 123]; reacts with hypochlorites to give N-chloroamines, some of which are explosives when isolated [Bretherick 1979. p. 108].
Health Hazard
Most toxic of the nitrogen mustards. The median lethal dose for inhalation is 1,500 mg-min/m3; for skin absorption (masked personnel) is 10,000 mg-min/m3. The medium incapacitating dose for eye injury is 200 mg-min/m3; for skin absorption is 2,500 mg-min/m3.
Fire Hazard
When heated to decomposition, TRIS-(2-CHLOROETHYL)-AMINE emits chloride and nitrogen oxides. No action on metals or other materials if material is kept dry. Avoid decomposing heat.
Potential Exposure
Trichlorotriethylamine is a (slowacting)
vesicant but has never been used in military conflict.
Is used as an antineoplastic agent. Has been tested as
a fixing agent in textile dyes.
Carcinogenicity
Tris(β-chloroethyl)amine was
tested for carcinogenic potential in mice and rats given
the material by subcutaneous injection. The study in mice
was considered inadequate for evaluation by the IARC.
However, in rats, this material induced a high incidence of
sarcomas (mostly spindle-cell type) in animals of each sex
at the site of injection, as well as a few intestinal adenocarcinomas;
neither tumor type was seen in controls.
Intravenous, intraperitoneal, and subcutaneous injection
to mice and rats produced tumors in 15–20% of treated
animals. The tumors included fibrosarcomas, lymphosarcomas,
and adenocarcinomas, and administration of a
single dose was as effective in inducing tumors as multiple
injections.
IARC considered the preceding data “sufficient evidence
of carcinogenicity in experimental animals.” Although no
human carcinogenicity data were available, the IARC classified
tris(β-chloroethyl)amine in Group 2B (the agent is
possibly carcinogenic to humans). This classification was
based on these animal studies, its mutagenic potential, and
analogy to other nitrogen mustards.
Shipping
UN2810 Toxic liquids, organic, n.o.s., Hazard
Class: 6.1; Labels: 6.1-Poisonous materials, Technical
Name Required. Military driver of HN-3 shall be given full
and complete information regarding shipment and conditions
in case of emergency. AR 50-6 deals specifically with
the shipment of chemical agents. Shipments of agent will
be escorted in accordance with AR 740-32.
Incompatibilities
HN-3 is not stable; it undergoes slow but
steady polymerization. Avoid contamination with oxidizers
(chlorates, nitrates, peroxides, permanganates, perchlorates,
chlorine, bromine, fluorine, bleaches and pool chemicalsetc);
contact may cause fires or explosions. Keep away from alkaline
materials, strong bases, strong acids, oxoacids, epoxides.
Unstable in the presence of light and heat and forms dimers
at temperatures above 50℃. HN-3 decomposes before its
boiling point is reached or condenses under all conditions;
the reactions involved could generate enough heat to cause
an explosion. Polymerizes slowly, so munitions would be
effective for several years. Heated to decomposition emits
hydrogen chloride and nitrogen oxide. Note: Chlorinating
agents destroy nitrogen mustards. Dry chlorinated lime and
chloramines with a high content of active chlorine vigorously
chlorinate nitrogen mustards to the carbon chain giving
low toxicity products. In the presence of water this interaction
proceeds less actively. They are rapidly oxidized by peracids
in aqueous solution at weakly alkaline pH. In acid
solution the oxidation is much slower.
Check Digit Verification of cas no
The CAS Registry Mumber 555-77-1 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 5,5 and 5 respectively; the second part has 2 digits, 7 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 555-77:
(5*5)+(4*5)+(3*5)+(2*7)+(1*7)=81
81 % 10 = 1
So 555-77-1 is a valid CAS Registry Number.
InChI:InChI=1/C6H12Cl3N.ClH/c7-1-4-10(5-2-8)6-3-9;/h1-6H2;1H
555-77-1Relevant articles and documents
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Mason,Gasch
, p. 2816 (1938)
-
Novel fluorine-containing betaine type surfactant as well as preparation method and application thereof
-
Paragraph 0033-0035; 0040-0042; 0046-0048; 0052-0054; 0058, (2021/04/14)
The invention discloses a novel fluorine-containing betaine surfactant, a preparation method and application thereof. The method includes: adopting an alcohol amine compound and fluorine-containing alcohol as the raw materials, carrying out deprotonation, halogenation and etherification are in order to obtain fluorine-containing tertiary amine, and then carrying out quaternization reaction with ahalide having different hydrophilic groups to obtain the fluorine-containing betaine surfactant. The surfactant has the advantages of easy degradation, no bioaccumulation and excellent surface activity, simple reaction mechanism, small environmental pollution and low cost. The invention not only improves the economic added value of octafluoropentanol, dodecafluoroheptanol, hexadecafluorononanol orother by-products, but also provides a wide source, cheap and easily new raw material for preparation of fluorine-containing surfactants, and solves the problem of difficult treatment of by-products.The novel, efficient, cheap and environment-friendly fluorine-containing surfactant provided by the invention has good application prospects.
Magnetic Relaxation Studies on Trigonal Bipyramidal Cobalt(II) Complexes
Shao, Feng,Cahier, Benjamin,Wang, Yi-Ting,Yang, Feng-Lei,Rivière, Eric,Guillot, Régis,Guihéry, Nathalie,Tong, Jia-Ping,Mallah, Talal
, p. 391 - 397 (2020/01/25)
We report the preparation and the full characterization of a novel mononuclear trigonal bipyramidal CoII complex [Co(NS3 iPr)Br](BPh4) (1) with the tetradentate sulfur-containing ligand NS3 iPr/