55668-04-7

Basic information

• Product Name: N⁽²⁾-acetyl-N⁽¹⁰⁾-trifluoroacetylpteroic acid
• Synonyms: N⁽²⁾-acetyl-N⁽¹⁰⁾-trifluoroacetylpteroic acid
• CAS NO: 55668-04-7
• Molecular Weight: 450.334
• Mol File: 55668-04-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N⁽²⁾-acetyl-N⁽¹⁰⁾-trifluoroacetylpteroic acid(CAS DataBase Reference)
• NIST Chemistry Reference: N⁽²⁾-acetyl-N⁽¹⁰⁾-trifluoroacetylpteroic acid(55668-04-7)
• EPA Substance Registry System: N⁽²⁾-acetyl-N⁽¹⁰⁾-trifluoroacetylpteroic acid(55668-04-7)

Safety Data

• Hazardous Substances Data: 55668-04-7(Hazardous Substances Data)

Upstream product

• 126063-08-9 2,2,2-trifluoro-N-(4-iodophenyl)acetamide 
• 404-26-2 4-(trifluoroacetamido)benzoic acid 
• 540-37-4 p-aminoiodobenzene 
• 150-13-0 4-amino-benzoic acid 

Downstream Products

• 119-24-4 pteroic acid 
• 59-30-3 folic acid 
• 71084-65-6 C₂₃H₂₁F₃N₆O₇ 

Relevant articles and documents

The synthesis of folic acid, multiply labelled with stable isotopes, for bio-availability studies in human nutrition

Two different methods for the synthesis of folic acid, which are suitable for the incorporation of compounds multiply labelled with stable isotopes, are described. The first method is based on the use of a novel reductive amination to link 2-acetyIamino-4-hydroxy-6-formylpteridine withp-aminobenzoyl-L-glutamic acid. The second method is based on the penultimate formation of an amide bond between Ar-2-acetyl-Ar-10-trifluoroacetyIpteroic acid and dimethyl L-glutamate. Both methods have been used to transform [13C6]aniline into folic acid, labelled with [13C6] in the p-aminobenzoate moiety, and [3,3,4,4-2H4]-L-glutamic acid into folic acid, labelled with [2H4] in the glutamate moiety. Doubly labelled [13C6,2H 4]-p-aminobenzoyl-L-glutamate has also been prepared by the former method.