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55676-22-7

55676-22-7

Identification

Synonyms:1-(6-Chloro-3-pyridinyl)-1-ethanone;1-(6-Chloro-3-pyridinyl)ethanone;6-Chloro-3-acetylpyridine;2-Chloro-5-acetylpyridine;3-Acetyl-6-chloropyridine;5-Acetyl-2-chloropyridine;

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Safety information and MSDS view more

  • Pictogram(s):R20/21/22:Harmful by inhalation, in contact with skin and if swallowed.; R36/37/38:Irritating to eyes, respiratory system

  • Hazard Codes:Xn

  • Signal Word:Warning

  • Hazard Statement:H315 Causes skin irritationH319 Causes serious eye irritation

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

  • Fire-fighting measures: Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

Supplier and reference price view more

  • Manufacture/Brand
  • Product Description
  • Packaging
  • Price
  • Delivery
  • Purchase
  • Manufacture/Brand:TRC
  • Product Description:1-(6-Chloropyridin-3-yl)ethanone
  • Packaging:100mg
  • Price:$ 60
  • Delivery:In stock
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  • Manufacture/Brand:TRC
  • Product Description:1-(6-Chloropyridin-3-yl)ethanone
  • Packaging:50mg
  • Price:$ 45
  • Delivery:In stock
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  • Manufacture/Brand:TCI Chemical
  • Product Description:5-Acetyl-2-chloropyridine >98.0%(GC)
  • Packaging:5g
  • Price:$ 113
  • Delivery:In stock
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  • Manufacture/Brand:TCI Chemical
  • Product Description:5-Acetyl-2-chloropyridine >98.0%(GC)
  • Packaging:1g
  • Price:$ 38
  • Delivery:In stock
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  • Manufacture/Brand:SynQuest Laboratories
  • Product Description:5-Acetyl-2-chloropyridine
  • Packaging:1 g
  • Price:$ 21
  • Delivery:In stock
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  • Manufacture/Brand:SynQuest Laboratories
  • Product Description:5-Acetyl-2-chloropyridine
  • Packaging:5 g
  • Price:$ 82
  • Delivery:In stock
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  • Manufacture/Brand:SynChem
  • Product Description:1-(6-Chloropyridin-3-yl)ethan-1-one 95%
  • Packaging:10 g
  • Price:$ 465
  • Delivery:In stock
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  • Manufacture/Brand:SynChem
  • Product Description:1-(6-Chloropyridin-3-yl)ethan-1-one 95%
  • Packaging:5 g
  • Price:$ 295
  • Delivery:In stock
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  • Manufacture/Brand:SynChem
  • Product Description:1-(6-Chloropyridin-3-yl)ethan-1-one 95%
  • Packaging:1 g
  • Price:$ 85
  • Delivery:In stock
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  • Manufacture/Brand:Matrix Scientific
  • Product Description:1-(6-Chloro-3-pyridinyl)-1-ethanone 95+%
  • Packaging:1g
  • Price:$ 18
  • Delivery:In stock
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Relevant articles and documentsAll total 35 Articles be found

Photoinduced Acetylation of Anilines under Aqueous and Catalyst-Free Conditions

Yang, Yu-Ming,Yan, Wei,Hu, Han-Wei,Luo, Yimin,Tang, Zhen-Yu,Luo, Zhuangzhu

, p. 12344 - 12353 (2021/09/02)

A green and efficient visible-light induced functionalization of anilines under mild conditions has been reported. Utilizing nontoxic, cost-effective, and water-soluble diacetyl as photosensitizer and acetylating reagent, and water as the solvent, a variety of anilines were converted into the corresponding aryl ketones, iodides, and bromides. With advantages of environmentally friendly conditions, simple operation, broad substrate scope, and functional group tolerance, this reaction represents a valuable method in organic synthesis.

INHIBITORS OF MUTANT ISOCITRATE DEHYDROGENASES AND COMPOSITIONS AND METHODS THEREOF

-

Paragraph 00157, (2018/07/29)

The invention provides novel chemical compounds useful for treating cancer, or a related disease or disorder thereof, and pharmaceutical composition and methods of preparation and use thereof.

High-activity iminophenylacetate compound, preparation method and applications thereof

-

Paragraph 0053, (2017/08/30)

The present invention belongs to the field of pesticides, and particularly relates to a high-activity iminophenylacetate compound, a preparation method and applications thereof. According to the present invention, the research of novel methoxy acrylate compounds is performed, a pyridine aryl ether structure is introduced into the structure of the novel methoxy acrylate compound, the research of the new compound structures is expanded, and the high-activity iminophenylacetate compound is found; and the compound has the bioactivity equal to azoxystrobin and trifloxystrobin, provides good effects on most pathogenic bacteria, especially provides significant prevention and treatment effects on Sclerotinia sclerotiorum bacterial, and is effective at a low doses.

Process route upstream and downstream products

Process route

dimethyl 2-(6-chloronicotinoyl)malonate
923034-23-5

dimethyl 2-(6-chloronicotinoyl)malonate

3-acetyl-6-chloropyridine
55676-22-7

3-acetyl-6-chloropyridine

Conditions
Conditions Yield
With water; In dimethyl sulfoxide; at 130 ℃; for 2h;
32%
With water; In dimethyl sulfoxide; at 130 ℃; for 2.5h;
32%
With water; dimethyl sulfoxide; at 155 ℃; Yield given;
With dimethyl sulfoxide;
In water; dimethyl sulfoxide; at 150 ℃; for 2h;
40.2 g
6-Chloronicotinoyl chloride
58757-38-3

6-Chloronicotinoyl chloride

malonic acid dimethyl ester
108-59-8

malonic acid dimethyl ester

3-acetyl-6-chloropyridine
55676-22-7

3-acetyl-6-chloropyridine

Conditions
Conditions Yield
malonic acid dimethyl ester; With triethylamine; magnesium chloride; In toluene; at 20 ℃; for 1.5h;
6-Chloronicotinoyl chloride; In toluene; for 2h;
In dimethyl sulfoxide; at 150 - 160 ℃; for 2h; Further stages.;
85%
6-Chloronicotinoyl chloride; malonic acid dimethyl ester; With triethylamine; magnesium chloride;
With water; In dimethyl sulfoxide; at 150 ℃;
80%
6-Chloronicotinoyl chloride; malonic acid dimethyl ester; With triethylamine; magnesium chloride; In toluene; at 25 ℃; for 0.666667h;
With water; dimethyl sulfoxide; at 155 ℃; for 3h; Further stages.;
80%
6-Chloronicotinoyl chloride; malonic acid dimethyl ester; With triethylamine; magnesium chloride; In toluene; at 20 ℃;
With hydrogenchloride; In water; toluene;
With water; In dimethyl sulfoxide; at 130 ℃; for 5h;
28%
malonic acid dimethyl ester; With triethylamine; magnesium chloride; In toluene; at 25 ℃; for 1.5h;
6-Chloronicotinoyl chloride; In toluene; for 1.41667h;
With dimethyl sulfoxide; In water; at 155 ℃; for 3h;
6-Chloronicotinoyl chloride
58757-38-3

6-Chloronicotinoyl chloride

3-acetyl-6-chloropyridine
55676-22-7

3-acetyl-6-chloropyridine

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1.1: MgCl2; Et3N / toluene / 1 h / 20 °C
1.2: toluene / 0.33 h
2.1: 40.2 g / dimethylsulfoxide; H2O / 2 h / 150 °C
With triethylamine; magnesium chloride; In water; dimethyl sulfoxide; toluene;
Multi-step reaction with 2 steps
1: MgCl2; Et3N
2: aq. DMSO
With dimethyl sulfoxide; triethylamine; magnesium chloride;
Multi-step reaction with 2 steps
1: Et3N / CH2Cl2
2: tetrahydrofuran
With triethylamine; In tetrahydrofuran; dichloromethane; 1: Substitution / 2: Substitution;
Multi-step reaction with 2 steps
1: toluene / 25 °C
2: DMSO, H2O / 155 °C
With water; dimethyl sulfoxide; In toluene;
diethyl malonate; With triethylamine; magnesium chloride; In toluene; at 20 ℃; for 1.5h;
6-Chloronicotinoyl chloride; In toluene; at 20 ℃; for 2h;
In water; dimethyl sulfoxide; at 150 - 160 ℃; for 2h;
Multi-step reaction with 2 steps
1: dichloromethane / 1 h / Large scale
2: dichloromethane; tert-butyl methyl ether / 1 h / Large scale
In dichloromethane; tert-butyl methyl ether;
5-bromo-2-chloropyridine
53939-30-3

5-bromo-2-chloropyridine

N-Methoxy-N-methylacetamide
78191-00-1

N-Methoxy-N-methylacetamide

3-acetyl-6-chloropyridine
55676-22-7

3-acetyl-6-chloropyridine

Conditions
Conditions Yield
5-bromo-2-chloropyridine; With TurboGrignard; In tetrahydrofuran; at 0 ℃; for 0.25h; Inert atmosphere;
N-Methoxy-N-methylacetamide; In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;
84%
2-chloro-5-(chloromethyl)pyridine
70258-18-3

2-chloro-5-(chloromethyl)pyridine

malonic acid dimethyl ester
108-59-8

malonic acid dimethyl ester

3-acetyl-6-chloropyridine
55676-22-7

3-acetyl-6-chloropyridine

Conditions
Conditions Yield
malonic acid dimethyl ester; With triethylamine; magnesium chloride; In toluene; at 25 ℃; for 1h;
2-chloro-5-(chloromethyl)pyridine; In toluene; for 1h;
With water; In dimethyl sulfoxide; at 165 ℃; for 2h;
68%
methylmagnesium bromide
75-16-1

methylmagnesium bromide

6-chloro-N-methoxy-N-methylpyridine-3-carboxamide
149281-42-5

6-chloro-N-methoxy-N-methylpyridine-3-carboxamide

3-acetyl-6-chloropyridine
55676-22-7

3-acetyl-6-chloropyridine

Conditions
Conditions Yield
In tetrahydrofuran; at 0 - 20 ℃; for 1h;
84%
2-chloropyridine-5-yldiazonium tetrafluoroborate

2-chloropyridine-5-yldiazonium tetrafluoroborate

dimethylglyoxal
431-03-8

dimethylglyoxal

3-acetyl-6-chloropyridine
55676-22-7

3-acetyl-6-chloropyridine

Conditions
Conditions Yield
With Langlois reagent; In acetonitrile; at 20 ℃; for 12h; Irradiation;
45%
C<sub>13</sub>H<sub>14</sub>ClNO<sub>5</sub>

C13H14ClNO5

3-acetyl-6-chloropyridine
55676-22-7

3-acetyl-6-chloropyridine

Conditions
Conditions Yield
In water; dimethyl sulfoxide; at 155 ℃; for 3h;
94 g
With dimethyl sulfoxide; at 160 ℃; for 6h;
6-chloronicotinonitrile
33252-28-7

6-chloronicotinonitrile

3-acetyl-6-chloropyridine
55676-22-7

3-acetyl-6-chloropyridine

Conditions
Conditions Yield
With hydrogenchloride; In tetrahydrofuran; diethyl ether;
6-Chloronicotinoyl chloride
58757-38-3

6-Chloronicotinoyl chloride

methylmagnesium bromide
75-16-1

methylmagnesium bromide

3-acetyl-6-chloropyridine
55676-22-7

3-acetyl-6-chloropyridine

Conditions
Conditions Yield
Fe(CH2COCH2COMe)3; In tetrahydrofuran; at -30 ℃; for 3h;
64.7%

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