55750-06-6Relevant articles and documents
Preparation method of imidocarb dipropionate and intermediate thereof
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, (2020/09/09)
The invention discloses a preparation method of imidocarb dipropionate and an intermediate thereof and belongs to the technical field of chemical pharmacy. According to the method, m-nitrobenzonitrilereacts with ethylenediamine with sodium sulfide taken as a catalyst; palladium on carbon-ammonium formate reduction is performed; a product and urea are subjected to condensation reaction, so that imidazole phenylurea dihydrochloride can be obtained; dissociated imidazole phenylurea reacts with propionic acid, so that the imidazole phenylurea dipropionate can be obtained. The method has the advantages o reduced wastes, cheap and easily available raw materials, simple operation, high product yield, simple process operation and high safety, and is suitable for industrial production.
Purification method of imidocarb
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Paragraph 0025; 0028; 0031; 0034; 0035; 0037, (2018/02/04)
The invention discloses a purification method of imidocarb. The method comprises specific steps as follows: a surfactant is added to a feed liquid of imidocarb, the mixture is stirred for a reaction and cooled for crystallization, and imidocarb is obtained through drying. Imidocarb is dissolved in an organic solvent, then water is added, PH is adjusted with propionic acid, the mixture is stirred for crystallization, and imidocard dipropionate is obtained through drying. The method is convenient to operate, easy to operate industrially and low in cost, and the content of imidocard dipropionate products can be 99.9% or higher.