55750-48-6

Basic information

• Product Name: N-METHOXYCARBONYLMALEIMIDE
• Synonyms: N-METHOXYCARBONYLMALEIMIDE;methyl 2,5-dihydro-2,5-dioxo-1H-pyrrole-1-carboxylate;2,5-Dihydro-2,5-dioxo-1H-pyrrole-1-carboxylic acid methyl ester;2,5-Dioxo-2,5-dihydro-1H-pyrrole-1-carboxylic acid methyl ester;2,5-Dioxo-3-pyrroline-1-carboxylic acid methyl ester;Einecs 259-792-3;N-(CarboMethoxy)MaleiMide;1H-Pyrrole-1-carboxylic acid, 2,5-dihydro-2,5-dioxo-, Methyl ester
• CAS NO: 55750-48-6
• Molecular Formula: C₆H₅NO₄
• Molecular Weight: 155.11
• EINECS: 259-792-3
• Product Categories: Nitric Oxide Reagents;Cross Linking Reagents;Maleimide Derivatives;MTS & Sulfhydryl Active Reagents;Carbonyl Compounds;Cyclic Imides;Organic Building Blocks;Building Blocks;Carbonyl Compounds;Chemical Synthesis;Cyclic Imides;Organic Building Blocks;Life Science Chemical Reagents
• Mol File: 55750-48-6.mol
• Article Data: 30

Chemical Properties

• Melting Point: 63-65 °C
• Boiling Point: 242.5 °C at 760 mmHg
• Flash Point: 100.4 °C
• Appearance: Off-White Cyrstalline Solid
• Density: 1.496 g/cm³
• Vapor Pressure: 0.0339mmHg at 25°C
• Refractive Index: 1.545
• Storage Temp.: 2-8°C
• Solubility: DMSO (Slightly), Ethyl Acetate (Slightly), Chloroform
• PKA: -3.17±0.20(Predicted)
• BRN: 1450638
• CAS DataBase Reference: N-METHOXYCARBONYLMALEIMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N-METHOXYCARBONYLMALEIMIDE(55750-48-6)
• EPA Substance Registry System: N-METHOXYCARBONYLMALEIMIDE(55750-48-6)

Safety Data

• Safety Statements: 22-24/25
• WGK Germany: 3
• F: 10
• Hazardous Substances Data: 55750-48-6(Hazardous Substances Data)

Usage

Chemical Properties

Off-White Cyrstalline Solid

Uses

N-(Methoxycarbonyl) Maleimide (cas# 55750-48-6) is a compound useful in organic synthesis.

InChI:InChI=1/C6H5NO4/c1-11-6(10)7-4(8)2-3-5(7)9/h2-3H,1H3

Upstream product

• 541-59-3 maleiimide 
• 79-22-1 methyl chloroformate 
• 107-31-3 Methyl formate 
• 2126-93-4 cholest-5-en-3-amine 
• 141-78-6 ethyl acetate 

Downstream Products

• 4856-87-5 N,N-hexamethylenebis(maleimide) 
• 17450-29-2 1-hexyl-1H-pyrrole-2,5-dione 
• 28537-73-7 1,1'-(octane-1,8-diyl)bis(1H-pyrrole-2,5-dione) 
• 39763-02-5 N,N'-Decamethylendimaleinimid 
• 139112-38-2 1,1',1''-(nitrilotris(ethane-2,1-diyl))tris(1H-pyrrole-2,5-dione) 
• 27574-80-7 N,N'-Dodecamethylenedimaleimide 
• 28537-69-1 N,N'-Trimethylen-dimaleinimid 
• 192212-24-1 tert-butyl 5-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)pentylcarbamate 
• 34321-81-8 1-(2-(2-hydroxyethoxy)ethyl)-1H-pyrrole-2,5-dione 
• 916918-03-1 C₂₁H₂₅N₃O₉ 
• 107-92-6 butyric acid 
• 1332702-04-1 tert-butyl ((1R,2R)-2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)cyclohexyl)carbamate 
• 1332702-03-0 tert-butyl ((1S,2S)-2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)cyclohexyl)carbamate 
• 131274-17-4 1-[2-(2-aminoethoxy)ethyl]-1H-pyrrole-2,5-dione trifluoroacetic acid 

Relevant articles and documents

A CONJUGATE OF A TUBULYSIN ANALOG WITH BRANCHED LINKERS

The present invention relates to the conjugation of a tubulysin analog compound to a cell-binding molecule with branched/side-chain linkers for having better delivery of the conjugate compound and targeted treatment of abnormal cells. It also relates to a branched-linkage method of conjugation of a tubulysin analog molecule to a cell-binding ligand, as well as methods of using the conjugate in targeted treatment of cancer, infection and autoimmune disease.

CONJUGATION LINKERS CONTAINING 2,3-DIAMINOSUCCINYL GROUP

Provided is a conjugate of a cytotoxic drug/molecule to a cell-binding molecule with a bis-linker (adual-linker) containing a 2, 3-diaminosuccinyl group. It also relates to preparation of the conjugate of a cytotoxic drug/molecule to a cell-binding molecule with the bis-linker, particularly when the drug having functional groups of amino, hydroxyl, diamino, amino-hydroxyl, dihydroxyl, carboxyl, hydrazine, aldehyde and thiol for conjugation with the bis-linker in a specific manner, as well as the therapeutic use of the conjugates.

Poly[(side-on mesogen)-Alt-(end-on mesogen)]: A compromised molecular arrangement

In recent years, sequence-controlled side-chain liquid crystal polymers (SCLCPs) have gained extensive interest because mesogenic units with different lengths and distributions can form various ordered sequences, which further endow LCP materials with diverse functions. In this manuscript, a side-chain side-on maleimide-containing monomer 2,5-bis-(4-butoxy-benzoyloxy)-benzoic acid 6-(2,5-dioxo-2,5-dihydro-pyrrol-1-yl)-hexyl ester (Y1801) and a side-chain end-on styrene-containing monomer 4′-[6-(4-vinyl-phenoxy)-hexyloxy]-biphenyl-4-carbonitrile (Y1802) are combined in one single macromolecular chain and orderly polymerized in an alternative sequence to form an alternating copolymer Poly(Y1801-Alt-Y1802). The chemical structure and alternating sequence of Poly(Y1801-Alt-Y1802) are confirmed by GPC and NMR techniques. The combination of DSC, POM, and WAXS data indicates that, although the side-on homopolymer PY1801 and the end-on homopolymer PY1802 both exhibit the nematic phase, their alternating copolymer Poly(Y1801-Alt-Y1802) shows an interdigitated smectic A phase, a compromised molecular arrangement instead. In addition, a strong fluorescence emission of Poly(Y1801-Alt-Y1802) is observed, which might provide this novel alternating-structured liquid crystal polymer with potential applications in luminescent materials and devices.