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55750-62-4

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55750-62-4 Usage

Description

3-Maleimido-propionic NHS ester contains a maleimide group and an NHS ester. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol.

Chemical Properties

White to off-white solid

Uses

Different sources of media describe the Uses of 55750-62-4 differently. You can refer to the following data:
1. 3-Maleimidopropionic acid N-hydroxysuccinimide ester is a reagent that is widely used for generating stable maleimide-activated carrier proteins that can spontaneously react with sulfhydryls. Alternatively these relatively stable maleimide-activated intermediates may be lyophilized and stored for later conjugation to a hapten.
2. A short, sulfhydryl and amino reactive heterobifunctional crosslinking reagent, N-Succinimidyl 3-maleimidopropionate can also been used in immunodiagnostics.

Check Digit Verification of cas no

The CAS Registry Mumber 55750-62-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,5,7,5 and 0 respectively; the second part has 2 digits, 6 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 55750-62:
(7*5)+(6*5)+(5*7)+(4*5)+(3*0)+(2*6)+(1*2)=134
134 % 10 = 4
So 55750-62-4 is a valid CAS Registry Number.
InChI:InChI=1/C11H10N2O6/c14-7-1-2-8(15)12(7)6-5-11(18)19-13-9(16)3-4-10(13)17/h1-2H,3-6H2

55750-62-4 Well-known Company Product Price

  • Brand
  • (Code)Product description
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  • TCI America

  • (S0427)  N-Succinimidyl 3-Maleimidopropionate [Cross-linking Reagent]  >98.0%(HPLC)(N)

  • 55750-62-4

  • 100mg

  • 780.00CNY

  • Detail
  • TCI America

  • (S0427)  N-Succinimidyl 3-Maleimidopropionate [Cross-linking Reagent]  >98.0%(HPLC)(N)

  • 55750-62-4

  • 1g

  • 2,350.00CNY

  • Detail
  • TCI America

  • (S0427)  N-Succinimidyl 3-Maleimidopropionate [Cross-linking Reagent]  >98.0%(HPLC)(N)

  • 55750-62-4

  • 5g

  • 6,480.00CNY

  • Detail
  • Alfa Aesar

  • (H27329)  3-Maleimidopropionic acid N-hydroxysuccinimide ester, 99%   

  • 55750-62-4

  • 250mg

  • 1318.0CNY

  • Detail
  • Alfa Aesar

  • (H27329)  3-Maleimidopropionic acid N-hydroxysuccinimide ester, 99%   

  • 55750-62-4

  • 1g

  • 3381.0CNY

  • Detail
  • Sigma

  • (358657)  3-Maleimidopropionic acid N-hydroxysuccinimide ester  99%

  • 55750-62-4

  • 358657-25MG

  • 1,436.76CNY

  • Detail

55750-62-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name N-Succinimidyl 3-maleimidopropionate

1.2 Other means of identification

Product number -
Other names (2,5-dioxopyrrolidin-1-yl) 3-(2,5-dioxopyrrol-1-yl)propanoate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:55750-62-4 SDS

55750-62-4Relevant articles and documents

Practical synthesis of maleimides and coumarin-linked probes for protein and antibody labelling via reduction of native disulfides

Song, Hong Y.,Ngai, Mun H.,Song, Zhen Y.,MacAry, Paul A.,Hobley, Jonathan,Lear, Martin J.

experimental part, p. 3400 - 3406 (2010/01/06)

The cellular tracking, detection and sensing of protein or antibody movement are important aspects to advance our understanding of biomolecular interactions and activity. Antibodies modified with fluorescent dyes are also valuable tools, especially in immunology research. We describe here a proof-of-principle study of a new water-soluble coumarin probe with a maleimide thiol-reacting unit to fluorescently tag biomolecules. Highlights include: (1) a convenient water-based preparation of N-substituted maleimides, (2) a one-pot preparation of activated maleimido-esters, and (3) a bio-conjugation protocol for the selenol-promoted reduction of native disulfide bonds and the 'site-specific' labelling of antibodies with no significant loss of activity.

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