55790-17-5

Basic information

• Product Name: Methyl 2-oxo-4-phenylpyrrolidine-3-carboxylate
• Synonyms: Methyl 2-oxo-4-phenylpyrrolidine-3-carboxylate
• CAS NO: 55790-17-5
• Molecular Formula: C₁₂H₁₃NO₃
• Molecular Weight: 219.24
• Mol File: 55790-17-5.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 409.5±45.0 °C(Predicted)
• Appearance: /
• Density: 1 +-.0.06 g/cm3(Predicted)
• PKA: 14.51±0.40(Predicted)
• CAS DataBase Reference: Methyl 2-oxo-4-phenylpyrrolidine-3-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 2-oxo-4-phenylpyrrolidine-3-carboxylate(55790-17-5)
• EPA Substance Registry System: Methyl 2-oxo-4-phenylpyrrolidine-3-carboxylate(55790-17-5)

Safety Data

• Hazardous Substances Data: 55790-17-5(Hazardous Substances Data)

Usage

Uses

methyl 2-oxo-4-phenylpyrrolidine-3-carboxylate is a reagent in the preparation of nitroethylpyrrolidone compounds.

Upstream product

• 55790-16-4 (2-nitro-1-phenyl-ethyl)-malonic acid dimethyl ester 
• 6626-84-2 dimethyl 2-benzylidenepropanedioate 
• 100-52-7 benzaldehyde 

Downstream Products

• 71657-88-0 (4R)-4-phenyl-2-pyrrolidone 
• 62624-45-7 (S)-4-phenyl-1-tosylpyrrolidin-2-one 
• 331417-35-7 2-oxo-4-phenylpyrrolidine-3-carbocylic acid hydrazide 
• 1341160-81-3 3-[1-(indol-3-yl)-2-nitroethyl]-3-methoxycarbonyl-4-phenyl-2-pyrrolidone 
• 1341160-80-2 3-methoxycarbonyl-3-[1-(1-methylbenzimidazol-2-yl)-2-nitroethyl]-4-phenyl-2-pyrrolidone 
• 1341160-70-0 3-[1-(4-N,N-dimethylaminophenyl)-2-nitroethyl]-3-methoxycarbonyl-4-phenyl-2-pyrrolidone 
• 1341160-73-3 3-methoxycarbonyl-3-[2-nitro-1-(4-chlorophenyl)-ethyl]-4-phenyl-2-pyrrolidone 
• 1217737-83-1 3-methoxycarbonyl-3-(2-nitro-1-phenylethyl)-4-phenyl-2-pyrrolidone 
• 1341160-86-8 3-[1-(1-benzylindol-3-yl)-2-nitroethyl]-3-methoxycarbonyl-4-phenyl-2-pyrrolidone 
• 1341160-82-4 3-methoxycarbonyl-3-[1-(1-methylindol-3-yl)-2-nitroethyl]-4-phenyl-2-pyrrolidone 
• 1341160-92-6 3-[1-(1-benzyl-2-methylindol-3-yl)-2-nitroethyl]-3-methoxycarbonyl-4-phenyl-2-pyrrolidone 
• 1341160-89-1 3-[1-(1,2-dimethylindol-3-yl)-2-nitroethyl]-3-methoxycarbonyl-4-phenyl-2-pyrrolidone 
• 1341160-88-0 3-methoxycarbonyl-3-[1-(2-methylindol-3-yl)-2-nitroethyl]-4-phenyl-2-pyrrolidone 
• 1005085-89-1 3-methoxycarbonyl-3-[2-nitro-1-(2-furyl)ethyl]-4-phenyl-2-pyrrolidone 

Relevant articles and documents

Efficient synthesis of β-aryl-γ-lactams and their resolution with (S)-Naproxen: Preparation of (R)- and (S)-Baclofen

An efficient synthesis of enantiomerically-pure β-aryl-γ-lactams is described. The principal feature of this synthesis is the practical resolution of β-aryl-γ-lactams with (S)-Naproxen. The procedure is based on the Michael addition of nitromethane to benzylidenemalonates, which was easily obtained, followed by the reduction of the γ-nitroester in the presence of Raney nickel and the subsequent saponification/decarboxylation reaction. The utility of this methodology was highlighted by the preparation of enantiomerically-pure (R)- and (S)-Baclofen hydrochloride.