55871-46-0

Basic information

• Product Name: Carbamic acid, [4-(aminosulfonyl)phenyl]-, phenylmethyl ester
• CAS NO: 55871-46-0
• Molecular Formula: C14H14N2O4S
• Molecular Weight: 306.342
• Mol File: 55871-46-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Carbamic acid, [4-(aminosulfonyl)phenyl]-, phenylmethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, [4-(aminosulfonyl)phenyl]-, phenylmethyl ester(55871-46-0)
• EPA Substance Registry System: Carbamic acid, [4-(aminosulfonyl)phenyl]-, phenylmethyl ester(55871-46-0)

Safety Data

• Hazardous Substances Data: 55871-46-0(Hazardous Substances Data)

Upstream product

• 54290-54-9 4-Benzyloxycarbonylaminobenzolsulfonsaeurechlorid 
• 501-53-1 benzyl chloroformate 
• 63-74-1 sulfanilamide 

Downstream Products

• 55871-47-1 C₁₆H₁₈N₂O₄S₂ 
• 51904-30-4 acetyl-(N-benzyl-sulfanilyl)-amine 
• 144-80-9 sulphaacetamide 
• 5661-13-2 N-(4-aminophenylsulfonyl)-2-phenylacetamide 
• 1449004-77-6 benzyl 4-(N-benzoylsulfamoyl)phenylcarbamate 
• 1449004-76-5 (S)-benzyl-4-(N-(2-(tert-butoxycarbonylamino)-2-phenylacetyl)-sulfamoyl)phenylcarbamate 
• 127-71-9 sulfabenzamide 
• 1449004-13-0 (S)-tert-butyl 2-(4-aminophenylsulfonamido)-2-oxo-1-phenylethylcarbamate 
• 1449004-35-6 2-(4-bromo-2-chlorophenoxy)-N-(4-(N-(N-tert-butoxycarbonyl-L-(2-phenyl)glycyl)sulfamoyl)phenylcarbamothioyl)acetamide 
• 1449004-31-2 2-(4-bromo-2-chlorophenoxy)-N-(4-(N-phenylacetylsulfamoyl)phenylcarbamothioyl)acetamide 
• 1449004-30-1 N-(4-(N-benzoylsulfamoyl)phenylcarbamothioyl)-2-(4-bromo-2-chlorophenoxy) acetamide 
• 847507-38-4 N-benzyloxycarbonyl-sulfanilic acid acetylamide 

Relevant articles and documents

Design and synthesis of N-(3-sulfamoylphenyl)amides as Trypanosoma brucei leucyl-tRNA synthetase inhibitors

The protozoan parasite Trypanosoma brucei (T. brucei) causes human African trypanosomiasis (HAT), which is a fatal and neglected disease in the tropic areas, and new treatments are urgently needed. Leucyl-tRNA synthetase (LeuRS) is an attractive target for the development of antimicrobial agents. In this work, starting from the hit compound thiourea ZCL539, we designed and synthesized a series of amides as effective T. brucei LeuRS (TbLeuRS) synthetic site inhibitors. The most potent compounds 74 and 91 showed IC50 of 0.24 and 0.25 μM, which were about 700-fold more potent than the starting hit compound. The structure-activity relationship was also discussed. These compounds provided a new scaffold and lead compounds for further development of antitrypanosomal agents.