5631-96-9

Basic information

• Product Name: 2-(2-CHLOROETHOXY)TETRAHYDRO-2H-PYRAN
• Synonyms: 2-(2-CHLOROETHOXY)TETRAHYDRO-2H-PYRAN;2-(2-chloroethoxy)oxane;2-(2-chloroethoxy)tetrahydropyran;2-(2-Chloroethoxy)tetrahydro-2H-pyran >=97.0%
• CAS NO: 5631-96-9
• Molecular Formula: C₇H₁₃ClO₂
• Molecular Weight: 164.63
• Mol File: 5631-96-9.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 80 °C8 mm Hg(lit.)
• Flash Point: 65 °C
• Appearance: /
• Density: 1.115 g/mL at 20 °C(lit.)
• Vapor Pressure: 0.0986mmHg at 25°C
• Refractive Index: n20/D 1.459
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 2-(2-CHLOROETHOXY)TETRAHYDRO-2H-PYRAN(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-CHLOROETHOXY)TETRAHYDRO-2H-PYRAN(5631-96-9)
• EPA Substance Registry System: 2-(2-CHLOROETHOXY)TETRAHYDRO-2H-PYRAN(5631-96-9)

Safety Data

• Safety Statements: 23-24/25
• WGK Germany: 3
• Hazardous Substances Data: 5631-96-9(Hazardous Substances Data)

Usage

General Description

2-(2-Chloroethoxy)tetrahydro-2H-pyran is a building block for introducing a protected 2-hydroxyethyl group.

InChI:InChI=1/C7H13ClO2/c8-4-6-10-7-3-1-2-5-9-7/h7H,1-6H2

Upstream product

• 110-87-2 3,4-dihydro-2H-pyran 
• 107-07-3 2-chloro-ethanol 

Downstream Products

• 205381-75-5 4-benzyloxyphenoxyethyl tetrahydro-2H-pyran-2-yl ether 
• 1061302-90-6 2-[6-(4-allyloxyphenyl)-1,4-dioxahexan-1-yl]-tetrahydro-2H-pyran 
• 18240-10-3 (+/-)-2-(3-cyclohexenyl)ethanol 
• 60564-98-9 1-[2-(Tetrahydro-pyran-2-yloxy)-ethyl]-cyclohex-3-enecarbonitrile 
• 1400998-10-8 1,4-di(2-tetrahydropyranyloxyethoxy)-2,3-benzenedicarbonitrile 
• 1198765-10-4 6-{1,1-dimethyl-2-[2-(tetrahydro-pyran-2-yloxy)-ethoxy]-ethyl}-2-(4-methoxy-benzyl)-3,4-dihydro-2H-isoquinolin-1-one 

Relevant articles and documents

Derivative containing nitrogen heterocyclic rings and application of derivative in retinal neovascularization diseases

The invention discloses a derivative containing nitrogen heterocyclic rings and application of the derivative in retinal neovascularization diseases. The derivative has the biological structural formula shown in the description, wherein R1, R2, R3 and R4 are respectively and independently selected from -H or -CN. Under the same concentration of 5microg/mL, the growth inhibition ratios of the embodiment II, the embodiment III and the embodiment IV to HRCEC are superior to a monoclonal antibody drug Avastin. By injecting the compound into a vitreous body, the formation of pathologic new vesselscan be reduced, so that the derivative of the formula I or the salt of the derivative can be used for deeply researching and developing retinal neovascularization relevant diseases such as retinal vein occlusion, proliferative diabetic retinopathy, subretinal neovascular membrane, neovascular glaucoma, retinopathy of prematurity and proliferative vitreoretinopathy.

BiCl3: A versatile catalyst for the tetrahydropyranylation and depyranylation of 1°,2°,3°, allylic, benzylic alcohols, and symmetric diols

Bismuth trichloride as mild reagent, has been found to be a worthful catalyst for tetrahydropyranylation of 1°,2°,3°, allylic, benzylic alcohols, and symmetric di-ols. At room temperature the reagent THP(3,4-dihydro-2H-pyran) was successfully employed as pyranylating agent in presence of BiCl3catalyst without the use of a solvent and the yields of the products were found to be 90-96%. Further, the depyranylation of alcohols was achieved in quantitative yield by simple addition of MeOH using the same catalyst. The developed method was showed good chemo-selectivity in symmetrical diols for mono THP protection.

AI(OTf)3 - A highly efficient catalyst for the tetrahydropyranylation of alcohols under solvent-free conditions

A simple and highly efficient method has been developed for the tetrahydropyranylation of alcohols by their reaction with 3,4-dihydro-2H-pyran (DHP) using a catalytic amount (0.01-1 mol%) of aluminium triflate under solvent-free conditions. The effect of various factors like temperature, amount of the catalyst, and molar ratio of substrates on the reaction conditions has also been studied. The comparative study of tetrahydropyranylation of benzyl alcohol using various catalysts including some reported ones shows the efficiency of this catalyst.