564-63-6

Basic information

• Product Name: 14-hydroxyandrost-4-ene-3,17-dione
• Synonyms: 14-Hydroxyandrost-4-ene-3,17-dione; androst-4-ene-3,17-dione, 14-hydroxy-
• CAS NO: 564-63-6
• Molecular Formula: C₁₉H₂₆O₃
• Molecular Weight: 302.4079
• Mol File: 564-63-6.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 468.5°C at 760 mmHg
• Flash Point: 251.2°C
• Density: 1.19g/cm³
• Vapor Pressure: 9.57E-11mmHg at 25°C
• Refractive Index: 1.572
• CAS DataBase Reference: 14-hydroxyandrost-4-ene-3,17-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 14-hydroxyandrost-4-ene-3,17-dione(564-63-6)
• EPA Substance Registry System: 14-hydroxyandrost-4-ene-3,17-dione(564-63-6)

Safety Data

• Hazardous Substances Data: 564-63-6(Hazardous Substances Data)

Upstream product

• 63-05-8 androst-4-ene-3,17-dione 
• 16031-66-6 14-hydroxy-4-pregnene-3,20-dione 
• 4075-20-1 14alpha-Hydroxytestosterone 
• 94991-86-3 3β,14α-dihydroxy-androst-5-en-17-one 
• 58-22-0 testosterone 
• 63-05-8 Androstenedione 
• 595-18-6 14,17,21-trihydroxy-pregn-4-ene-3,20-dione 
• 57-83-0 progesterone 
• 853-23-6 prasterone acetate 
• 1443-89-6 3β-acetoxy-14α-hydroxyandrost-5-en-17-one 

Downstream Products

• 17305-51-0 5α-Androsten-(14)-on-(3) 
• 17305-43-0 5β-Androsten-(14)-dion-(3,17) 

Relevant articles and documents

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Biotransformation of androst-4-ene-3,17-dione by some fungi

The incubations of androst-4-ene-3,17-dione with Aspergillus candidus MRC 200634, Aspergillus tamarii MRC 72400, Aspergillus wentii MRC 200316 and Mucor hiemalis MRC 70325 for 5 days are reported. A. candidus MRC 200634 mainly hydroxylated androst-4-ene-3,17-dione at C-11α, C-15α and C-15β whilst A. wentii MRC 200316 hydroxylated it mainly at C-6β. A. tamarii MRC 72400 showed predominately a Baeyer–Villiger monooxygenase activity. M. hiemalis MRC 70325 hydroxylated the substrate at C-14α and reduced most of it at C-17.

Biotransformation of some steroids by Mucor hiemalis MRC 70325

In this work, incubations of testosterone, dehydroepiandrosterone and pregnenolone with Mucor hiemalis MRC 70325 have been reported. Incubation of testosterone afforded androst-4-en-3,17-dione (3%), 14a-hydroxyandrost- 4-en-3,17-dione (9%), 6β-hydroxyandrost-4-en-3,17-dione (2%) and 14a,17β-dihydroxyandrost-4-en-3-one (62%). Incubation of dehy droepiandrosterone afforded 3β,17β-dihydroxyandrost-5-ene (6%) and 3β,7α-dihydroxyandrost-5- en-17-one (72%). Incubation of pregnenolone afforded 3β,14a-dihydroxypregn-5-en-7,20-dione (3%), 3β,7α- dihydroxypregn- 5-en-20-one (64%) and 3β,7α,11α- trihydroxypregn-5-en-20-one (11%). 3β,14a-Dihydroxypregn-5-en-7,20-dione was identified as a new metabolite. Website