5653-11-2Relevant articles and documents
Copper-catalyzed aerobic cyclizations of tetrahydroisoquinolines with bromoketones and alkenes for the synthesis of 5,6-dihydropyrrolo[2,1-a] isoquinolines
Wang, Wenhui,Sun, Jinwei,Hu, Huayou,Liu, Yun
, p. 1651 - 1658 (2018/03/21)
A new copper-catalyzed oxidative cyclization protocol was developed for the synthesis of 5,6-dihydropyrrolo[2,1-a]isoquinolines via a three-component reaction of tetrahydroisoquinolines with bromoketones and electron-deficient alkenes with air as a termin
The Reactions of α-Arylsulfonoxy Ketones with Nucleophiles
Hoffman, Robert V.,Jankowski, Bryan C.,Carr, C. Sean,Duesler, Eileen N.
, p. 130 - 135 (2007/10/02)
α-(p-Nitrophenyl)sulfonoxy ketones can be converted to α-hydroxy ketals and α-hydroxy ketones by reaction with potassium carbonate and basic or acidic workup, respectively.They also react with amines to give α-amino ketones in high yields.Nonnucleophilic amines give an intramolecular aromatic substitution in the derived enolate.Factors which dictate the reaction patterns in these compounds are discussed.