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57078-99-6

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57078-99-6 Usage

Description

5-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)pentanoic acid contains a maleimide group and a terminal carboxylic acid. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol.

Uses

5-Maleimidopentanoic Acid is a potential inhibitor of prostaglandin endoperoxide synthase (PGHS)?.

Check Digit Verification of cas no

The CAS Registry Mumber 57078-99-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,7,0,7 and 8 respectively; the second part has 2 digits, 9 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 57078-99:
(7*5)+(6*7)+(5*0)+(4*7)+(3*8)+(2*9)+(1*9)=156
156 % 10 = 6
So 57078-99-6 is a valid CAS Registry Number.

57078-99-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 5-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)pentanoic acid

1.2 Other means of identification

Product number -
Other names 5-(2,5-dioxopyrrol-1-yl)pentanoic acid

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:57078-99-6 SDS

57078-99-6Downstream Products

57078-99-6Relevant articles and documents

Lactam analogues of galiellalactone

Nilsson, Jakob,Gidl?f, Ritha,Johansson, Martin,Sterner, Olov

, p. 3336 - 3341 (2012)

A synthetic route to lactam analogues of the fungal STAT3 inhibitor galiellalactone is presented. The synthesis involves a one-pot tosylamide amide coupling/intramolecular Michael addition and an introduction of an α,β-unsaturation, regioselectively directed by the tosyl functionality. An iodolactonization of the octahydroindolizine 9 and a re-opening of the lactone were employed for introducing an iodo substituent, facilitating the preparation of 8-substituted analogues (e.g., 4) using a Suzuki cross-coupling.

CONJUGATE OF CELL-BINDING RECEPTOR WITH CYTOTOXIC AGENT

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Paragraph 0223; 0224, (2017/10/31)

PROBLEM TO BE SOLVED: To provide a conjugate of a potent cytotoxic agent with a cell-surface receptor binding molecule for targeted treatment. SOLUTION: According to the present invention, there is provided a conjugate having a structure of formula (I) and a pharmaceutical acceptable salt and a solvate thereof. The conjugate is used for treating cancer, autoimmune disease, and infectious disease. (T is a targeting or binding ligand; L is a releasable linker; a broken line is a linkage bond that L connects to a molecule inside the bracket independently; n is an integer of 1 to 20; m is an integer of 1 to 10; and a structure in parentheses is a potent antimitotic agent/drug.) SELECTED DRAWING: None COPYRIGHT: (C)2017,JPOandINPIT

Conjugates of Cell Binding Molecules with Cytotoxic Agents

-

, (2017/11/06)

A conjugate of a potent cytotoxic agent with a cell-surface receptor binding molecule having a Formula (I), wherein T, L, m, n, R1, R2, R3, R4, R5, R6, R7, R8, R9

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