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57330-37-7

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57330-37-7 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 57330-37-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,7,3,3 and 0 respectively; the second part has 2 digits, 3 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 57330-37:
(7*5)+(6*7)+(5*3)+(4*3)+(3*0)+(2*3)+(1*7)=117
117 % 10 = 7
So 57330-37-7 is a valid CAS Registry Number.

57330-37-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name (4-chlorophenyl)[2-methyl-6-(trifluoromethoxy)-1H-indol-3-yl]methanone

1.2 Other means of identification

Product number -
Other names 3-p-Chlorbenzoyl-2-methyl-6-trifluormethoxy-indol

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:57330-37-7 SDS

57330-37-7Relevant articles and documents

Practical, highly convergent, asymmetric synthesis of a selective PPARγ modulator

Maligres, Peter E.,Humphrey, Guy R.,Marcoux, Jean-Francois,Hillier, Michael C.,Zhao, Dalian,Krska, Shane,Grabowski, Edward J.J.

experimental part, p. 525 - 534 (2010/04/22)

A practical, highly convergent, asymmetric synthesis of a selective PPARγ modulator 1 is described. The inhibitor contains two key components, a 6-trifluoromethoxy-3-acylindole (6) and (R)-raryloxybutanoic acid derivative (10). Twomethods were developed to overcome the regioselectivity issues encountered in the preparation of the 6-substituted indole. The first involved an intramolecular Heck reaction of an iodoaryl enamine. The second involved application of a catalytic Meerwein arylation reaction between 2-nitro-4-trifluoromethoxyaniline and isopropenyl acetate and subsequent reductive cyclization. The α-aryloxybutanoic acid was prepared via an asymmetric hydrogenation of the corresponding α-aryloxy-α,β- unsaturated acid. Tetrabutylammonium iodidecatalyzed coupling of the two fragments and ester hydrolysis completed the convergent synthesis. The described convergent synthesis was used to prepare >3 kg of drug substance 1 in 50% overall yield and with >99.5% ee.

INDOLES HAVING ANTI-DIABETIC ACTIVITY

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Page/Page column 29, (2008/06/13)

Indoles of Formula (I) having -X-aryl-(CH2)x#191-oxazolidinedione and -X-heteroaryl-(CH2)X-oxazolidinedione substituents on the N atom of the indole ring, where x is 0 or 1, and -X-is a bond or -CH2-, and their thiazolidinedione analogs, are PPAR gamma agonists or partial agonists and are useful in the treatment and control of type II diabetes, including hyperglycemia, dyslipidemia, hyperlipidemia, hypercholesterolemia, hypertriglyceridemia, and obesity that are often associated with type 2 diabetes.

INDOLES HAVING ANTI-DIABETIC ACTIVITY

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Page 54, (2010/02/06)

Indoles having aryloxyalkanoic acid substituents or arylalkanoic acid substituents are agonists or partial agonists of PPAR gamma and are useful in the treatment and control of hyperglycemia that is symptomatic of type II diabetes, as well as dyslipidemia, hyperlipidemia, hypercholesterolemia, hypertriglyceridemia, and obesity that are often associated with type 2 diabetes.

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