5736-88-9Relevant articles and documents
Tuning the SOCT-ISC of bodipy based photosentizers by introducing different electron donating groups and its application in triplet-triplet-annihilation upconversion
Liang, Hui,Sun, Shanshan,Zafar, Mahmood,Yuan, Zhanxiang,Dong, Yuye,Ji, Shaomin,Huo, Yanping,Li, Ming-De,Zhao, Jianzhang
, (2020)
To study the effect of electron-donating ability on spin orbit charge transfer intersystem crossing (SOCT-ISC) efficiency, a series of bodipy derivatives (BDP-O, BDP-2-MN, BDP-2-EN) linked with electron-donating groups with different electron-donor abilities were synthesized. For BDP-2-MN and BDP-2-EN, both compounds show a sharp charge transfer emission band at 630 nm, and the local excited (LE) emission in both compounds were completely quenched due to photo-induced electron transfer (PET). By femtosecond transient absorption measurement, the triplet state population in both compounds was confirmed to occur through charge recombination (1996 ps ~2307 ps) process after the photo-induced electron transfer upon photoexcitation of bodipy moiety. A long-lived triplet excited state was observed for both compounds (lifetimes: 37 ~ 42 μs) via nanosecond transient absorption. The BDP-2-MN and BDP-2-EN can act as the triplet photosensitizers without heavy elements for the application of triplet-triplet-annihilation upconversion (TTA-UC, ΦUC can reach 4.88%). In case of BDP-O molecule, no triplet signal was observed for this compound because of poor electronic coupling between donor and acceptor. Therefore, the triplet excited state properties of bodipy chromophore was successfully regulated by adjusting electronic strength of donor moiety and implement these photosensitizers in the application of TTA-UC.
Novel N-heterocyclic carbene cyclic palladium compound as well as preparation method and application thereof
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Paragraph 0027; 0031; 0034, (2021/06/26)
The invention discloses a novel N-heterocyclic carbene cyclic palladium compound as well as a preparation method and application thereof, and belongs to the technical field of organic catalysis. The novel N-heterocyclic carbene cyclic palladium compound is prepared by the following steps: heating, stirring and mixing N-(4-butoxybenzyl)-N-ethylethylamine, palladium chloride and an organic solvent in an inert gas atmosphere, then adding potassium carbonate, performing stirring and mixing, and finally adding 1-(2,6-diisopropyl phenyl)-3-butyl-brominated imidazole for reflux reaction; and after the reaction is finished, performing quenching with an acid solution, performing extracting to obtain a crude product, and performing column chromatography separation and purification to obtain the novel N-heterocyclic carbene cyclic palladium compound. The N-heterocyclic carbene cyclic palladium compound provided by the invention has high catalytic activity, can catalyze cross-coupling reactions between aryl chloride and aryl phenylboronic acid and between aryl chloride and secondary amine in a catalytic amount of 1 mol%, and can be used as a high-efficiency catalyst for the coupling reactions.
1,3-Oxazine-2-one derived dual-targeted molecules against replicating and non-replicating forms of Mycobacterium tuberculosis
Velappan, Anand Babu,Kesamsetty, Dhanunjaya,Datta, Dhrubajyoti,Ma, Rui,Hari, Natarajan,Franzblau, Scott G.,Debnath, Joy
supporting information, (2020/10/02)
The high mortality rate and increasing prevalence of resistant Mtb are the major concerns for the Tuberculosis (TB) treatment in this century. To curtail the prevalence of resistant Mtb, we have prepared 1,3-oxazine-2-one based dual targeted molecules. Compound 67 and 68 were found to be equally active against replicating and non-replicatiing form of Mtb (MICMABA 3.48 and 2.97 μg/ml; MICLORA 2.94 and 2.15 μg/ml respectively). They had found to suppress the biosynthesis of alfa, methoxy and keto-mycolate completely, as well as inhibit enzymatic activity of MenG (IC50 = 9.11 and 6.25 μg/ml respectively for H37Ra; IC50 = 11.76 and 10.88 μg/ml respectively for M smegmatis).
