57654-36-1

Basic information

• Product Name: 3,6-DI-4-PYRIDYL-1,2,4,5-TETRAZINE
• Synonyms: 3,6-DI-4-PYRIDYL-1,2,4,5-TETRAZINE;3,6-BIS(4-PYRIDYL)-1,2,4,5-TETRAZINE;2,5-DI-(4-PYRIDYL)-S-TETRAZINE;3,6-di(pyridin-4-yl)-1,2,4,5-tetrazine;3,6-Di(pyridin-4-yl)
• CAS NO: 57654-36-1
• Molecular Formula: C₁₂H₈N₆
• Molecular Weight: 236.23
• Mol File: 57654-36-1.mol
• Article Data: 19

Chemical Properties

• Melting Point: 257 °C
• Boiling Point: 528.1°C at 760 mmHg
• Flash Point: 255.9°C
• Appearance: /
• Density: 1.317g/cm³
• Vapor Pressure: 1.04E-10mmHg at 25°C
• Refractive Index: 1.632
• Storage Temp.: 2-8°C
• PKA: -0.88±0.10(Predicted)
• CAS DataBase Reference: 3,6-DI-4-PYRIDYL-1,2,4,5-TETRAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3,6-DI-4-PYRIDYL-1,2,4,5-TETRAZINE(57654-36-1)
• EPA Substance Registry System: 3,6-DI-4-PYRIDYL-1,2,4,5-TETRAZINE(57654-36-1)

Safety Data

• Hazardous Substances Data: 57654-36-1(Hazardous Substances Data)

Usage

General Description

3,6-Di-4-pyridyl-1,2,4,5-tetrazine is a chemical compound with the molecular formula C8H6N6. It is a tetrazine derivative that is commonly used in the field of bioconjugation, where it is utilized as a labeling reagent for biomolecules such as proteins and peptides. 3,6-DI-4-PYRIDYL-1,2,4,5-TETRAZINE is known for its fast and selective reactivity with trans-cyclooctene, making it a valuable tool for chemical biology and bioorthogonal chemistry applications. 3,6-Di-4-pyridyl-1,2,4,5-tetrazine is considered to be stable under physiological conditions, which further enhances its utility for in vivo imaging and drug delivery studies.

InChI:InChI=1/C12H8N6/c1-5-13-6-2-9(1)11-15-17-12(18-16-11)10-3-7-14-8-4-10/h1-8H

Upstream product

• 110-86-1 pyridine 
• 54-85-3 isoniazid 
• 31599-25-4 3,6-di-pyridin-4-yl-1,2-dihydro-[1,2,4,5]tetrazine 
• 100-48-1 pyridine-4-carbonitrile 
• 31599-25-4 3,6-di(pyridin-4-yl)-1,4-dihydro-1,2,4,5-tetrazine 

Downstream Products

• 1356539-57-5 3,3-dimethyl-8-(4-pyridyl)-1-(p-tolyl)pyrido[c]cyclopenta[b]pyrrol-2-one 
• 1356539-64-4 6-(3,3-dimethyl-4-oxo-1-(p-tolyl)azetidin-2-yl)-3,3-dimethyl-8-(4-pyridyl)1-(p-tolyl)pyrido[c]cyclopenta[b]pyrrol-2-one 
• 1356539-59-7 1-(4-chlorophenyl)-3,3-dimethyl-8-(4-pyridyl)pyrido[c]cyclopenta[b]pyrrol-2-one 
• 1356539-67-7 1-(4-chlorophenyl)-6-[1-(4-chlorophenyl)-3,3-dimethyl-4-oxo-azetidin-2-yl]-3,3-dimethyl-8-(4-pyridyl)pyrido[c]cyclopenta[b]pyrrol-2-one 
• 1356539-68-8 6-[3,3-diethyl-1-(4-methoxyphenyl)-4-oxo-azetidin-2-yl]-3,3-diethyl-1-(4-methoxyphenyl)-8-(4-pyridyl)pyrido[c]cyclopenta[b]pyrrol-2-one 
• 1356539-62-2 C₂₆H₂₃N₃O₂ 
• 1356539-69-9 6'-[1''-(4-methoxyphenyl)-spiro[cyclopentane-1,3''-(4''-oxo-azetidin-2''-yl)]]1'-(4-methoxyphenyl)-8'-(4-pyridyl)spiro[cyclopentane-1,3'-pyrido[c]cyclopenta[b]pyrrol]-2'-one 
• 1356539-61-1 3-ethyl-3-methyl-8-(4-pyridyl)-1-(p-tolyl)pyrido[c]cyclopenta[b]pyrrol-2-one 
• 1356539-56-4 3,3-dimethyl-1-phenyl-8-(4-pyridyl)pyrido[c]cyclopenta[b]pyrrol-2-one 
• 1356539-63-3 3,3-dimethyl-6-(3,3-dimethyl-4-oxo-1-phenylazetidin-2-yl)-1-phenyl-8-(4-pyridyl)pyrido[c]cyclopenta[b]pyrrol-2-one 
• 1356539-58-6 3,3-dimethyl-1-(4-methoxyphenyl)-8-(4-pyridyl)pyrido[c]cyclopenta[b]pyrrol-2-one 

Relevant articles and documents

Post-synthetic Modification of a Dinuclear Spin Crossover Iron(III) Complex

The dinuclear iron(III) complex [Fe(salten)2(bipytz)](BPh4)2·EtOH (1) was synthesized and its post-synthesis modification yielded [Fe(salten)2(bipydz)](BPh4)2·EtOH (2). The crystal structures and magnetic behaviors of 1 and 2 were investigated by variable temperature XRD, magnetic susceptibility, and M?ssbauer spectra measurements, with each of these dinuclear iron(III) complexes exhibiting gradual spin crossover behavior.

Improvement of Methane-Framework Interaction by Controlling Pore Size and Functionality of Pillared MOFs

The rational design of functionalized porous metal-organic frameworks (MOFs) for gas adsorption applications has been applied using three spacer ligands H2DPT (3,6-di(pyridin-4-yl)-1,4-dihydro-1,2,4,5-tetrazine), DPT (3,6-di(pyridin-4-yl)-1,2,4

Double Solvent Sensing Method for Improving Sensitivity and Accuracy of Hg(II) Detection Based on Different Signal Transduction of a Tetrazine-Functionalized Pillared Metal-Organic Framework

To design a robust, π-conjugated, low-cost, and easy to synthesize metal-organic framework (MOF) for cation sensing by the photoluminescence (PL) method, 4,4′-oxybis(benzoic acid) (H2OBA) has been used in combination with 3,6-di(pyridin-4-yl)-1

Template-directed synthesis of pyridazine-containing tetracationic cyclophane for construction of [2]rotaxane

Benefiting from its bent molecular structure, 3,6-pyridazinyl contained tetracationic cyclophane (1) is synthesized by template-directed method with high isolated yield up to 92%. This template-directed strategy is further utilized to efficiently construct [2]rotaxane.