5799-76-8

Basic information

• Product Name: 1-PROP-2-YN-1-YLPYRROLIDINE
• Synonyms: 1-PROP-2-YN-1-YLPYRROLIDINE;4-(prop-2-ynyl)Morpholine;1-(N-Morpholino)-2-propyne;4-PropargylMorpholine;1-Morpholino-2-propyne;3-(4-morpholinyl)-1-propyne;Morpholine, 4-(2-propynyl)-
• CAS NO: 5799-76-8
• Molecular Formula: C₇H₁₁NO
• Molecular Weight: 125.17
• Mol File: 5799-76-8.mol
• Article Data: 65

Chemical Properties

• Boiling Point: 186°C(lit.)
• Flash Point: 45.8°C
• Appearance: /
• Density: 0.99g/cm³
• Vapor Pressure: 1.65mmHg at 25°C
• Refractive Index: 1.4730 to 1.4770
• Storage Temp.: 2-8°C
• PKA: 5.14±0.10(Predicted)
• CAS DataBase Reference: 1-PROP-2-YN-1-YLPYRROLIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-PROP-2-YN-1-YLPYRROLIDINE(5799-76-8)
• EPA Substance Registry System: 1-PROP-2-YN-1-YLPYRROLIDINE(5799-76-8)

Safety Data

• RIDADR: UN 1993 3/PG III
• HazardClass: 3
• PackingGroup: III
• Hazardous Substances Data: 5799-76-8(Hazardous Substances Data)

Usage

General Description

1-PROP-2-YN-1-YLPYRROLIDINE, also known as 1-(2-propyn-1-yl)pyrrolidine, is a chemical compound with the molecular formula C8H13N. It is classified as an alkyne chemical, characterized by a carbon-carbon triple bond. 1-PROP-2-YN-1-YLPYRROLIDINE is commonly used as a building block in organic synthesis and can be utilized in various chemical reactions to create more complex molecules. It is also used in the pharmaceutical industry as an intermediate in the synthesis of drugs and other bioactive compounds. Additionally, 1-PROP-2-YN-1-YLPYRROLIDINE may have potential applications in biochemical and medicinal research due to its unique chemical structure and reactivity. However, it is important to handle this compound with proper safety measures and precautions due to its potential hazardous properties.

InChI:InChI=1/C7H11NO/c1-2-3-8-4-6-9-7-5-8/h1H,3-7H2

Upstream product

• 110-91-8 morpholine 
• 106-96-7 propargyl bromide 
• 50-00-0 formaldehyd 
• 75-20-7 calcium carbide 
• 107-19-7 propargyl alcohol 
• 109-02-4 4-methyl-morpholine 
• 110-62-3 pentanal 
• 75-09-2 dichloromethane 
• 71145-90-9 N-prop-2-ynylmorpholine N-oxide 
• 59998-22-0 4-Pent-4-en-2-ynyl-4-prop-2-ynyl-morpholin-4-ium; bromide 
• 109-89-7 diethylamine 
• 124-40-3 dimethyl amine 
• 110-89-4 piperidine 
• 74-86-2 acetylene 

Downstream Products

• 86325-16-8 4-morpholino-1-phenyl-but-2-yn-1-one 
• 101724-70-3 dimethyl-(6-morpholino-hex-4-ynyl)-amine 
• 63868-56-4 3-ethoxy-4-morpholino-crotonic acid ethyl ester 
• 86325-94-2 1,3,5-tris(morpholinomethyl)benzene 
• 678161-76-7 4-(4-fluorophenyl)-1-methyl-5-[3-(4-morpholinyl)-1-propynyl]-3-(4-pyridinyl)-1N-pyrrole-2-carboxylic acid methyl ester 
• 1065040-26-7 ethyl 2-(N-acetylamino)-5-(3-N-morpholinoprop-1-yn-1-yl)benzoate 
• 51639-25-9 (C₆H₅)2SbCCCH₂NC₄H₈O 
• 1046155-06-9 4-[3,3-dideutero-2-(phenylseleno)allyl]morpholine 
• 1046154-99-7 4-[2-(phenylseleno)allyl]morpholine 
• 1046154-88-4 (E)-4-[2,3-bis(phenylseleno)allyl]morpholine 
• 1046154-98-6 4-[2-(phenylthio)allyl]morpholine 
• 1581276-12-1 methyl 4-hydroxy-3-(3-morpholinoprop-1-yn-1-yl)benzoate 
• 1581276-50-7 C₂₁H₂₀BNO₆ 
• 1581276-11-0 methyl 4-acetoxy-3-(3-morpholinoprop-1-yn-1-yl)benzoate 

Relevant articles and documents

Corrosion inhibition performance of a structurally well-defined 1,2,3-triazole derivative on mild steel-hydrochloric acid interface

In the present work, a new 1,4-disubstituted-1,2,3-triazole product, named 4-[1-(4-methoxy-phenyl)-1H-[1,2,3]triazol-4-ylmethyl]-morpholine (MPTM) was successfully synthesized under click chemistry regime. The structure of the new compound that has a rigi

A click chemistry approach to pleuromutilin derivatives, evaluation of anti-MRSA activity and elucidation of binding mode by surface plasmon resonance and molecular docking

Novel series of pleuromutilin analogs containing substituted 1,2,3-triazole moieties were designed, synthesised and assessed for their in vitro antibacterial activity against Methicillin-resistant Staphylococcus aureus (MRSA). Initially, the in vitro antibacterial activities of these derivatives against 4 strains of S. aureus (MRSA ATCC 43300, ATCC 29213, AD3, and 144) were tested by the broth dilution method. Most of the synthesised pleuromutilin analogs displayed potent activities. Among them, compounds 50, 62, and 64 (MIC = 0.5～1 μg/mL) showed the most effective antibacterial activity and their anti-MRSA activity were further studied by the time-killing kinetics approach. Binding mode investigations by surface plasmon resonance (SPR) with 50S ribosome revealed that the selected compounds all showed obvious affinity for 50S ribosome (KD = 2.32 × 10?8～5.10 × 10?5 M). Subsequently, the binding of compounds 50 and 64 to the 50S ribosome was further investigated by molecular modelling. Compound 50 had a superior docking mode with 50S ribosome, and the binding free energy of compound 50 was calculated to be ?12.0 kcal/mol.

BTK Inhibitors and uses thereof

The invention discloses a bruton's tyrosine kinase (BTK) inhibitor and use thereof. Specifically, the invention provides heteroaromatic compounds or stereoisomers, geometrical isomers, tautomers, racemates, nitrogen oxides, hydrates, solvates, metabolites and pharmaceutically acceptable salts or prodrugs thereof, and pharmaceutical compositions containing the heteroaromatic compounds; the invention also discloses use of the heteroaromatic compounds or the pharmaceutical compositions containing the heteroaromatic compounds in preparation of medicines; the medicines can be used for treating autoimmune diseases, inflammatory diseases or proliferative diseases.