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57999-09-4

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57999-09-4 Usage

General Description

4-(4-chloro-phenyl)-2H-pyrazol-3-ylamine is a chemical compound that belongs to the family of pyrazole derivatives. It is an organic compound with the molecular formula C10H9ClN4, with a molecular weight of 206.66 g/mol. This chemical is used in various fields, including pharmaceuticals, agrochemicals, and material science. It has potential applications in the development of new drugs and pesticides due to its unique chemical properties. Additionally, it may also have uses in research and development of new materials and compounds. Overall, 4-(4-chloro-phenyl)-2H-pyrazol-3-ylamine is a versatile chemical compound with a wide range of potential applications in different industries.

Check Digit Verification of cas no

The CAS Registry Mumber 57999-09-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,7,9,9 and 9 respectively; the second part has 2 digits, 0 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 57999-09:
(7*5)+(6*7)+(5*9)+(4*9)+(3*9)+(2*0)+(1*9)=194
194 % 10 = 4
So 57999-09-4 is a valid CAS Registry Number.
InChI:InChI=1/C9H8ClN3/c10-7-3-1-6(2-4-7)8-5-12-13-9(8)11/h1-5H,(H3,11,12,13)

57999-09-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-(4-CHLORO-PHENYL)-2H-PYRAZOL-3-YLAMINE

1.2 Other means of identification

Product number -
Other names BUTTPARK 49 7-33

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:57999-09-4 SDS

57999-09-4Relevant articles and documents

Synthesis and biological evaluation of novel pyrazolo[1,5-a]pyrimidines: Discovery of a selective inhibitor of JAK1 JH2 pseudokinase and VPS34

Singleton, Justin D.,Dass, Reuben,Neubert, Nathaniel R.,Smith, Rachel M.,Webber, Zak,Hansen, Marc D.H.,Peterson, Matt A.

supporting information, (2019/12/24)

A series of novel 3,6-di-substituted or 3-substituted pyrazolo[1,5-a]pyrimidines were prepared via a microwave-assisted approach that generated a broad array of derivatives in good yields (20–93%, ave. = 59%). The straightforward synthesis involved sequential treatment of commercially-available acetonitrile derivatives with DMF-dimethylacetal (120 °C, 20 min), followed by treatment with NH2NH2·HBr (120 °C, 20 min), and 1,1,3,3-tetramethoxypropane or 2-aryl-substituted malondialdehdyes (120 °C, 20 min). Compounds were screened for antimitotic activities against MCF7 breast cancer and/or A2780 ovarian cancer cell lines in vitro. The most active compounds exhibited EC50 values ranging from 0.5 to 4.3 μM, with the 3-(4-(trifluoromethyl)phenyl)-6-[4-(2-(piperidin-1-yl)ethoxy]phenyl analogue (34e) and the 3-(2-fluorophenyl)-6-[4-(2-(4-methylpiperizin-1-yl)ethoxy]phenyl analogue (35a) being two to three fold more active than Compound C (Dorsomorphin) in A2780 and MCF7 assays, respectively. Importantly, a monosubstituted 3-(benzothiazol-2-yl) derivative (13) was equipotent with the more synthetically challenging 3,6-disubstituted derivatives (34a–e and 35a–e), and exhibited a promising and unique selectivity profile when screened against a panel consisting of 403 protein kinases (Kinomescan selectivity score = 0.005, Kd = 0.55 ± 0.055 μM and 0.410 ± 0.20 μM for JAK1 JH2 pseudokinase and VPS34, respectively).

A new, one-pot, multicomponent synthesis of 5-aza-9-deaza-adenines under microwave irradiation

Lim, Felicia Phei Lin,Luna, Giuseppe,Dolzhenko, Anton V.

, p. 5159 - 5163 (2014/12/10)

A new, practical, three-component method for the synthesis of 5-aza-9-deaza-adenines is developed. Aminopyrazoles react in a one-pot fashion with triethyl orthoformate and cyanamide under microwave irradiation affording 5-aza-9-deaza-adenines in good yiel

HETEROCYCLIC COMPOUNDS FOR THE INHIBITION OF PASK

-

, (2012/11/08)

Disclosed herein are new heterocyclic compounds and compositions and their application as pharmaceuticals for the treatment of disease. Methods of inhibiting PAS Kinase (PASK) activity in a human or animal subject are also provided for the treatment of diseases such as diabetes mellitus.

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