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5834-16-2

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5834-16-2 Usage

Chemical Properties

clear yellow to brown liquid

Uses

Different sources of media describe the Uses of 5834-16-2 differently. You can refer to the following data:
1. 3-Methyl-2-thiophenecarboxaldehyde is used in the synthesis of 2,3-dimethyl-5-(2,6,10-trimethylundecyl)thiophene. It is also used to investigate versatile bioconversion capacity of baker′s yeast for the generation of thiols from cysteine-aldehyde conjugates.
2. 3-Methyl-2-thiophenecarboxaldehyde was used in the synthesis of 2,3-dimethyl-5-(2,6,10-trimethylundecyl)thiophene. It was used to investigate versatile bioconversion capacity of baker′s yeast for the generation of thiols from cysteine-aldehyde conjugates.

Check Digit Verification of cas no

The CAS Registry Mumber 5834-16-2 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 5,8,3 and 4 respectively; the second part has 2 digits, 1 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 5834-16:
(6*5)+(5*8)+(4*3)+(3*4)+(2*1)+(1*6)=102
102 % 10 = 2
So 5834-16-2 is a valid CAS Registry Number.
InChI:InChI=1/C6H6OS/c1-5-2-3-8-6(5)4-7/h2-4H,1H3

5834-16-2 Well-known Company Product Price

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  • (Code)Product description
  • CAS number
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  • Detail
  • Alfa Aesar

  • (L14741)  3-Methylthiophene-2-carboxaldehyde, 98+%   

  • 5834-16-2

  • 5g

  • 266.0CNY

  • Detail
  • Alfa Aesar

  • (L14741)  3-Methylthiophene-2-carboxaldehyde, 98+%   

  • 5834-16-2

  • 25g

  • 974.0CNY

  • Detail
  • Alfa Aesar

  • (A13961)  3-Methylthiophene-2-carboxaldehyde, tech. 90%   

  • 5834-16-2

  • 25g

  • 351.0CNY

  • Detail
  • Alfa Aesar

  • (A13961)  3-Methylthiophene-2-carboxaldehyde, tech. 90%   

  • 5834-16-2

  • 100g

  • 1047.0CNY

  • Detail
  • Aldrich

  • (164135)  3-Methyl-2-thiophenecarboxaldehyde  90%, technical grade

  • 5834-16-2

  • 164135-25G

  • 314.85CNY

  • Detail

5834-16-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name 3-Methyl-2-thiophenecarboxaldehyde

1.2 Other means of identification

Product number -
Other names 3-Methyl-2-thiophenecarboxalde

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:5834-16-2 SDS

5834-16-2Relevant articles and documents

Regioselective electrophilic formylation - 3-substituted thiophenes as a case study

Meth-Cohn, Otto,Ashton, Mark

, p. 2749 - 2752 (2000)

A variety of methods for regioselective formylation have been examined and exemplified with 3-methylthiophene. Optimal yields and regioselectivity for 2-formylation were obtained with N-formylpyrrolidine (11:1) although up to a 46:1 ratio could be obtained with MeOCHCl2:TiCl4, albeit in lower yield. Optimal 5-formylation (1:1.5) was obtained when using N- formylindoline:(COCl)2. (C) 2000 Elsevier Science Ltd.

Systematic structure-activity relationship (SAR) exploration of diarylmethane backbone and discovery of a highly potent novel uric acid transporter 1 (URAT1) inhibitor

Cai, Wenqing,Wu, Jingwei,Liu, Wei,Xie, Yafei,Liu, Yuqiang,Zhang, Shuo,Xu, Weiren,Tang, Lida,Wang, Jianwu,Zhao, Guilong

, (2018/02/07)

In order to systematically explore and better understand the structure-activity relationship (SAR) of a diarylmethane backbone in the design of potent uric acid transporter 1 (URAT1) inhibitors, 33 compounds (1a-1x and 1ha-1hi) were designed and synthesized, and their in vitro URAT1 inhibitory activities (IC50) were determined. The three-round systematic SAR exploration led to the discovery of a highly potent novel URAT1 inhibitor, 1h, which was 200-and 8-fold more potent than parent lesinurad and benzbromarone, respectively (IC50 = 0.035 μM against human URAT1 for 1h vs. 7.18 μM and 0.28 μM for lesinurad and benzbromarone, respectively). Compound 1h is the most potent URAT1 inhibitor discovered in our laboratories so far and also comparable to the most potent ones currently under development in clinical trials. The present study demonstrates that the diarylmethane backbone represents a very promising molecular scaffold for the design of potent URAT1 inhibitors.

Chemoselective Reduction of Sterically Demanding N,N-Diisopropylamides to Aldehydes

Xiao, Peihong,Tang, Zhixing,Wang, Kai,Chen, Hua,Guo, Qianyou,Chu, Yang,Gao, Lu,Song, Zhenlei

, p. 1687 - 1700 (2018/02/23)

A sequential one-pot process for chemoselectively reducing sterically demanding N,N-diisopropylamides to aldehydes has been developed. In this reaction, amides are activated with EtOTf to form imidates, which are reduced with LiAlH(OR)3 [R = t-Bu, Et] to give aldehydes by hydrolysis of the resulting hemiaminals. The non-nucleophilic base 2,6-DTBMP remarkably improves reaction efficiency. The combination of EtOTf/2,6-DTBMP and LiAlH(O-t-Bu)3 was found to be optimal for reducing alkyl, alkenyl, alkynyl, and 2-monosubstituted aryl N,N-diisopropylamides. In contrast, EtOTf and LiAlH(OEt)3 in the absence of base were found to be optimal for reducing extremely sterically demanding 2,6-disubstituted N,N-diisopropylbenzamides. The reaction tolerates various reducible functional groups, including aldehyde and ketone. 1H NMR studies confirmed the formation of imidates stable in water. The synthetic usefulness of this methodology was demonstrated with N,N-diisopropylamide-directed ortho-metalation and C-H bond activation.

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