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584-48-5

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584-48-5 Usage

Chemical Properties

YELLOW CRYSTALLINE SOLID

Uses

Different sources of media describe the Uses of 584-48-5 differently. You can refer to the following data:
1. 1-Bromo-2,4-dinitrobenzene has been used in the preparation of 2,4-dinitrophenol via treatment with KO2-crown ether complex in benzene. It is used as substrate in protein determination and glutathione S-transferase (GST) assay of chicken and rat prostaglandin D2 synthase (PGDS).
2. 1-Bromo-2,4-dinitrobenzene has been used:in the preparation of 2,4-dinitrophenol via treatment with KO2-crown ether complex in benzeneas substrate in protein determination and glutathione S-transferase (GST) assay of chicken and rat prostaglandin D2 synthase (PGDS)

Definition

ChEBI: An organobromine compound that is bromobenzene substituted at C-2 and -4 with nitro groups.

Purification Methods

Crystallise it from ethyl ether, isopropyl ether, 80% EtOH or absolute EtOH. [Beilstein 5 III 640, 5 IV 749.]

Check Digit Verification of cas no

The CAS Registry Mumber 584-48-5 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 5,8 and 4 respectively; the second part has 2 digits, 4 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 584-48:
(5*5)+(4*8)+(3*4)+(2*4)+(1*8)=85
85 % 10 = 5
So 584-48-5 is a valid CAS Registry Number.
InChI:InChI=1/C6H3BrN2O4/c7-5-2-1-4(8(10)11)3-6(5)9(12)13/h1-3H

584-48-5 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
  • Packaging
  • Price
  • Detail
  • Alfa Aesar

  • (B22867)  1-Bromo-2,4-dinitrobenzene, 98%   

  • 584-48-5

  • 25g

  • 516.0CNY

  • Detail
  • Alfa Aesar

  • (B22867)  1-Bromo-2,4-dinitrobenzene, 98%   

  • 584-48-5

  • 100g

  • 1471.0CNY

  • Detail
  • Aldrich

  • (262226)  1-Bromo-2,4-dinitrobenzene  97%

  • 584-48-5

  • 262226-25G

  • 827.19CNY

  • Detail

584-48-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name 2,4-dinitrobromobenzene

1.2 Other means of identification

Product number -
Other names 2-bromo-1,5-dinitrobenzene

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:584-48-5 SDS

584-48-5Relevant articles and documents

Metal- and base-free synthesis of aryl bromides from arylhydrazines

Phuc Tran, Dat,Nomoto, Akihiro,Mita, Soichiro,Dong, Chun-ping,Kodama, Shintaro,Mizuno, Takumi,Ogawa, Akiya

supporting information, (2020/05/08)

An efficient method was developed to synthesize brominated aromatic compounds from arylhydrazine hydrochlorides by using BBr3 in DMSO/CPME (cyclopentyl methyl ether) under air at 80 °C for 1 h without the use of bases or metal catalysts. In particular, this method could be carried out satisfactorily using electron-withdrawing groups to afford aryl bromides in a moderate to excellent yields.

Novel carbazole sulfonamide derivatives of antitumor agent: Synthesis, antiproliferative activity and aqueous solubility

Sun, Lianqi,Wu, Yanbin,Liu, Yonghua,Chen, Xiaofang,Hu, Laixing

, p. 261 - 265 (2016/12/27)

The current optimization of IG-105 (3) on the carbazole-ring provided a series of new carbazole sulfonamides derivatives 13a–13m. All of the compounds have been evaluated against HepG2 cells (hepatoma cancer) for antiproliferative activity. Compounds that showed activity better or comparable to that of 3 versus HepG2 were evaluated against MCF-7 (breast cancer), MIA PaCa-2 (pancreatic cancer), and Bel-7402 (hepatoma/liver cancer) for antiproliferative activity. Of the seven compounds selected for further study five (13b, 13g, 13j, 13k and 13l) were found to give IC50values against the four cell lines comparable to those for 3. Two compounds (13f and 13i) were more active than 3 and their activity against HepG2 and MCF-7 (IC50:0.01–0.07?μM) approached that of the positive controls podophyllotoxin (podo) and CA-4. Most of compounds showed aqueous solubility (0.11–19.60?μg/mL at pH 7.4 and 2.0) better than 3. These promising results warrant further development of new compounds 13f and 13i as potential potent antitumor drug candidates.

Aromatic allylation via diazotization: Metal-free C-C bond formation

Ek, Fredrik,Axelsson, Oskar,Wistrand, Lars-Goeran,Frejd, Torbjoern

, p. 6376 - 6381 (2007/10/03)

A new method for the synthesis of allyl aromatic compounds not involving any metal-containing reagent or catalyst has been developed. Arylamines substituted with a large number of different substituents were converted via diazotizative deamination with tert-butyl nitrite in allyl bromide and acetonitrile to the corresponding allyl aromatic compounds. The allylation reaction was found to be suitable for larger scale synthesis due to short reaction times, a nonextractive workup, and robustness toward moisture, air, and type of solvent.

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