5848-04-4

Basic information

• Product Name: 4-(4-fluorophenyl)-1H-pyrazol-5-amine
• Synonyms: 1H-Pyrazol-3-amine, 4-(4-fluorophenyl)-; 1H-Pyrazol-5-amine, 4-(4-fluorophenyl)-; 4-(4-Fluorophenyl)-1H-pyrazol-3-amine; 4-(4-Fluorophenyl)-1H-pyrazol-5-amine
• CAS NO: 5848-04-4
• Molecular Formula: C₉H₈FN₃
• Molecular Weight: 177.1783
• Mol File: 5848-04-4.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 388.8°C at 760 mmHg
• Flash Point: 189°C
• Density: 1.334g/cm³
• Vapor Pressure: 2.98E-06mmHg at 25°C
• Refractive Index: 1.636
• CAS DataBase Reference: 4-(4-fluorophenyl)-1H-pyrazol-5-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-fluorophenyl)-1H-pyrazol-5-amine(5848-04-4)
• EPA Substance Registry System: 4-(4-fluorophenyl)-1H-pyrazol-5-amine(5848-04-4)

Safety Data

• Hazardous Substances Data: 5848-04-4(Hazardous Substances Data)

Usage

General Description

4-(4-fluorophenyl)-1H-pyrazol-5-amine is a chemical compound with the molecular formula C9H8N3F. It is an aromatic amine derivative with a pyrazole ring structure, and a fluorine atom attached to one of the phenyl rings. 4-(4-fluorophenyl)-1H-pyrazol-5-amine is a potential pharmaceutical intermediate with potential applications in the synthesis of various drugs due to its aromatic and amine functional groups. Its properties and potential uses make it an interesting target for further research and development in the pharmaceutical and chemical industries.

Upstream product

• 459-22-3 4-fluorophenylacetonitrile 
• 398-42-5 2-formyl-2-(4-fluorophenyl) acetonitrile 

Downstream Products

• 1448466-65-6 8-(4-fluorophenyl)-2-thioxo-2,3-dihydropyrazolo[1,5-a][1,3,5]triazin-4(1H)-one 
• 1448466-49-6 1,3-dihydro-8-(4-fluorophenyl)pyrazolo[1,5-a][1,3,5]triazin-2,4-dione 

Relevant articles and documents

Development of Pyrazolopyrimidine Anti- Wolbachia Agents for the Treatment of Filariasis

Anti-Wolbachia therapy has been identified as a viable treatment for combating filarial diseases. Phenotypic screening revealed a series of pyrazolopyrimidine hits with potent anti-Wolbachia activity. This paper focuses on the exploration of the SAR for this chemotype, with improvement of metabolic stability and solubility profiles using medicinal chemistry approaches. Organic synthesis has enabled functionalization of the pyrazolopyrimidine core at multiple positions, generating a library of compounds of which many analogues possess nanomolar activity against Wolbachia in vitro with improved DMPK parameters. A lead compound, 15f, was selected for in vivo pharmacokinetics (PK) profiling in mice. The combination of potent anti-Wolbachia activity in two in vitro assessments plus the exceptional oral PK profiles in mice puts this lead compound in a strong position for in vivo proof-of-concept pharmacodynamics studies and demonstrates the strong potential for further optimization and development of this series for treatment of filariasis in the future.