58728-64-6

Basic information

• Product Name: 4-AMINO-1-NAPHTHALENECARBONITRILE
• Synonyms: 4-AMINO-1-NAPHTHALENECARBONITRILLE 98%;4-Amino-1-naphthalenecarbonitrille, 98%;4-Amino-1-naphthalenecarbonitrile,98%;1-Amino-4-cyano naphthalene;4-amino-1-naphthalenecarbonitril;4-CYANO-1-NAPHTHYLAMINE;4-AMINO-1-NAPHTHALENECARBONITRILE;4-AMINO-1-NAPHTHONITRILE
• CAS NO: 58728-64-6
• Molecular Formula: C₁₁H₈N₂
• Molecular Weight: 168.19
• EINECS: 261-412-6
• Product Categories: Building Blocks;C10 to C27;Chemical Synthesis;Cyanides/Nitriles;Nitrogen Compounds;Organic Building Blocks
• Mol File: 58728-64-6.mol

Chemical Properties

• Melting Point: 174.5-176.5 °C(lit.)
• Boiling Point: 287.13°C (rough estimate)
• Flash Point: 191.1 °C
• Appearance: brown fluffy powder or fine needles
• Density: 1.1722 (rough estimate)
• Vapor Pressure: 2.3E-06mmHg at 25°C
• Refractive Index: 1.5200 (estimate)
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 1.76±0.10(Predicted)
• CAS DataBase Reference: 4-AMINO-1-NAPHTHALENECARBONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-AMINO-1-NAPHTHALENECARBONITRILE(58728-64-6)
• EPA Substance Registry System: 4-AMINO-1-NAPHTHALENECARBONITRILE(58728-64-6)

Safety Data

• Hazard Codes: Xn
• Statements: 20/21/22
• Safety Statements: 36
• WGK Germany: 3
• RTECS: QJ1865000
• Hazardous Substances Data: 58728-64-6(Hazardous Substances Data)

Usage

Uses

Used in Chemical Synthesis:
4-Amino-1-naphthalenecarbonitrile is used as a chemical intermediate for the synthesis of various compounds, including pharmaceuticals, dyes, and pigments. Its unique structure allows for further functionalization and modification, making it a versatile building block in the chemical industry.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 4-Amino-1-naphthalenecarbonitrile is used as a key component in the development of new drugs. Its ability to form various derivatives and complexes with other molecules makes it a valuable asset in the design and synthesis of novel therapeutic agents.
Used in Dye and Pigment Industry:
4-Amino-1-naphthalenecarbonitrile is utilized as a starting material for the production of dyes and pigments. Its chemical properties enable the creation of a wide range of colors and shades, making it an essential component in the formulation of various colorants for the textile, paint, and plastics industries.
Used in Research and Development:
In the field of research and development, 4-Amino-1-naphthalenecarbonitrile serves as a valuable compound for studying the properties and behavior of naphthalene-based compounds. Its reactivity and structural characteristics make it an ideal candidate for exploring new chemical reactions and understanding the underlying mechanisms involved.

InChI:InChI=1/C11H8N2/c12-7-8-5-6-11(13)10-4-2-1-3-9(8)10/h1-6H,13H2

Upstream product

• 129667-52-3 4-acetylamino-[1]naphthonitrile 
• 92616-49-4 4-bromonaphthalene-1-carbonitrile 
• 3029-30-9 naphthalene-1,4-dicarbonitrile 
• 23245-63-8 4-Nitronaphthalene-1-carbonitrile 

Downstream Products

• 86410-93-7 4-(hexadecylamino)-1-naphthonitrile 
• 86410-94-8 4-(dihexadecylamino)-1-naphthonitrile 
• 23245-63-8 4-Nitronaphthalene-1-carbonitrile 
• 180977-12-2 (S)-2-{[4-((R)-2-tert-Butoxycarbonylamino-3-tritylsulfanyl-propionylamino)-naphthalene-1-carbonyl]-amino}-4-methylsulfanyl-butyric acid methyl ester 
• 95092-84-5 4-Ethoxycarbonyl-1-naphthylamine 
• 95092-75-4 4-<<(benzyloxy)carbonyl>amino>-1-naphthoic acid 
• 95092-40-3 phenyl 4-guanidino-1-naphthoate 
• 140456-96-8 1-cyano-4-iodonaphthalene 
• 364082-22-4 N-(4-Cyano-1-naphthyl)-4-[trans-5-[[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]thio]-1,3-dioxan-2-yl]benzamide 
• 496841-43-1 (2S,4R)-4-Benzyloxy-2-(4-cyano-naphthalen-1-ylcarbamoyl)-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 92616-49-4 4-bromonaphthalene-1-carbonitrile 

Relevant articles and documents

Benzimidazole derivatives as well as preparation method and application thereof

The invention belongs to the field of medicine, and relates to preparation methods of a series of benzimidazole derivatives, pharmaceutical salts of the benzimidazole derivatives and a pharmaceutically acceptable prodrug, pharmaceutical composition containing the derivatives, as well as an application of the derivatives and the pharmaceutical composition in preparation of anti-gout drugs and treatment of related diseases.

Acid-base properties of substituted naphthoic acids in nonaqueous media

Thirteen substituted 1-naphthoic acids have been prepared and their dissociation constants, along with those of twenty-five substituted 2-naphthoic acids, have been measured potentiometrically in methanol, N,N-dimethylformamide, pyridine, and acetonitrile. The pKHA values obtained have been treated by linear regression using four sets of substituent constants. The experimental data have also been interpreted by statistical methods using latent variables. The first latent variable calculated by these methods can be used as a new set of substituent constants for describing substituent effects in naphthalene skeleton.

The Photochemical Reactions of 9,10-Anthracenedicarbonitrile and 1,4-Naphthalenedicarbonitrile in Acetonitrile in the Presence of Bases

Irradiation of 9,10-anthracenedicarbonitrile (DCA) in MeCN-MeOH or MeCN-H2O containing hydroxides or methoxides leads to 9-methylimino-10-anthracenecarbonitrile (isolated, but easily hydrolyzed to the corresponding amine).Minor products are polycyanated amines and 9-hydroxy-10-anthracenecarbonitrile.Irradiation in neat MeOH causes decyanation.In both cases the first step is reduction to DCA-*, which persists for hour under these conditions.Evidence for the mechanism leading from the radical anion to the observed products is supplied.The key steps are protonation to yield the radical DCAH* and addition of the latter to acetonitrile, or to better nucleophiles when these are present. 1,4-Naphthalenedicarbonitrile is similarly transformed to the 4-amino-1-carbonitrile.