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588-64-7

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588-64-7 Usage

General Description

Benzaldehyde Phenylhydrazone is a chemical compound with the formula C13H12N2. It is an aromatic hydrazone derived from phenylhydrazine and benzaldehyde. It exists as a yellowish crystalline powder at room temperature and it tends to darken upon exposure to air. The compound exhibits some interesting properties like photoluminescence, which can be exploited for optical and electronic applications. It's used in scientific research, specifically in the field of organic synthesis where it often serves as a reagent or building block for more complex molecules. As for safety, it should be handled with care as it may cause irritation to skin, eyes, and respiratory tract if not appropriately managed.

Check Digit Verification of cas no

The CAS Registry Mumber 588-64-7 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 5,8 and 8 respectively; the second part has 2 digits, 6 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 588-64:
(5*5)+(4*8)+(3*8)+(2*6)+(1*4)=97
97 % 10 = 7
So 588-64-7 is a valid CAS Registry Number.
InChI:InChI=1/C13H12N2/c1-3-7-12(8-4-1)11-14-15-13-9-5-2-6-10-13/h1-11,15H/b14-11+

588-64-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name Benzaldehyde Phenylhydrazone

1.2 Other means of identification

Product number -
Other names BENZALDEHYDE PHENYLHYDRAZONE

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:588-64-7 SDS

588-64-7Relevant articles and documents

Dual-parameter correlations on rate of dehydration step of a condensation reaction in aqueous solutions of ethanol, propan-2-ol and 2-methylpropan-2-ol

Habibi Yangjeh,Gholami,Mostaghim

, p. 884 - 889 (2001)

The reaction kinetics of the dehydration step of the condensation reaction between phenylhydrazine and benzaldehyde was studied spectrophotometrically in aqueous solutions of ethanol, propan-2-ol and 2-methylpropan-2-ol at pH 11.5 at 25 °C. The apparent second-order rate constants k2app of the reaction increase with mole fraction of water in all the aqueous solutions. Single-parameter correlations of log k2app versus π* (dipolarity/polarizability), α (hydrogen-bond donor acidity) and ETN (normalized polarity parameter) were obtained in all the aqueous solutions. In all cases, the correlations versus ETN and π* are acceptable, but correlations versus α are poor (e.g. in aqueous solutions of ethanol the correlation coefficients are 0.964, 0.967, and 0.751 respectively). The results of dual-parameter correlations of log k2app versus π* and α in all cases represent improvements with regard to the single-parameter models (in aqueous solutions of ethanol r = 0.995; s.e. = 0.038; n = 13). The apparent second-order rate constants of the reaction increase with α, π* and ETN. Increasing the hydrogen-bond donor acidity of the solvent stabilizes the activated complex of the reaction via hydrogen-bond formation with the intermediate. A dual-parameter equation of log k2app versus π* and α was obtained for the combined data set of aqueous solutions (n = 35, r = 0.989, s.e. = 0.062, F2.32 = 719.21), in which π* has the major effect on the reaction rate relative to α. Copyright

METHODS OF FORMING IMINES, IMINE-RELATED AND IMINE-DERIVED COMPOUNDS USING GREEN SOLVENTS

-

Paragraph 0186-0189, (2021/10/22)

The present disclosure relates to using green solvents to synthesize an array of imines, imine-related and imine-derived compounds in an efficient and eco-friendly matter, satisfying green chemistry requirements. Reaction embodiments are performed using solvents, such as ethyl lactate and dimethyl isosorbide, which are both individually characterized as green. In embodiments, solvents include lactic whey and/or water as co-solvents. In these green solvents, the synthesis process discussed herein can produce up to quantitative yields of product at room temperature in a short duration. Embodiments include a method of forming an imine, imine-related or imine-derived compound product. In embodiments, the methods include mixing an aldehyde reactant with a nucleophilic/nitrogen-containing reactant in a green solvent at a temperature between negative twenty degrees Celsius (?20° C.) and positive fifty degrees Celsius (50° C.); stirring the mixture; and forming an imine, imine-related or imine-derived compound product.

Identification of novel 1,3-diaryl-1,2,4-triazole-capped histone deacetylase 6 inhibitors with potential anti-gastric cancer activity

Zhang, Xin-Hui,Kang, Hui-Qin,Tao, Yuan-Yuan,Li, Yi-Han,Zhao, Jun-Ru,Ya-Gao,Ma, Li-Ying,Liu, Hong-Min

, (2021/04/12)

Histone deacetylase 6 (HDAC6) has emerged as a critical regulator of many cellular pathways in tumors due to its unique structure basis and abundant substrate types. Over the past few decades, the role played by HDAC6 inhibitors as anticancer agents has sparked great interest of biochemists worldwide. However, they were less reported for gastric cancer therapy. In this paper, with the help of bioisosteric replacement, in-house library screening, and lead optimization strategies, we designed, synthesized and verified a series of 1,3-diaryl-1,2,4-triazole-capped HDAC6 inhibitors with promising anti-gastric cancer activities. Amongst, compound 9r displayed the best inhibitory activity towards HDAC6 (IC50 = 30.6 nM), with 128-fold selectivity over HDAC1. Further BLI and CETSA assay proved the high affinity of 9r to HDAC6. In addition, 9r could dose-dependently upregulate the levels of acetylated α-tubulin, without significant effect on acetylated histone H3 in MGC803 cells. Besides, 9r exhibited potent antiproliferative effect on MGC803 cells, and promoted apoptosis and suppressed the metastasis without obvious toxicity, suggesting 9r would serve as a potential lead compound for the development of novel therapeutic agents of gastric cancer.

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