58859-46-4

Basic information

• Product Name: Ethyl 4-amino-1-piperidinecarboxylate
• Synonyms: ETHYL 4-AMINOPIPERIDINE-1-CARBOXYLATE;ETHYL 4-AMINO-1-PIPERIDINECARBOXYLATE;4-AMINO-1-PIPERIDINECARBOXYLIC ACID ETHYL ESTER;4-AMINO-1-CARBETHOXYPIPERIDINE;4-AMINO-PIPERIDINE-1-CARBOXYLIC ACID ETHYL ESTER;N-CARBETHOXY-4-AMINOPIPERIDINE;N-CARBETHOXY-4-AMINO-PIPERIDONE;TIMTEC-BB SBB003834
• CAS NO: 58859-46-4
• Molecular Formula: C₈H₁₆N₂O₂
• Molecular Weight: 172.22
• EINECS: 261-472-3
• Product Categories: Piperidines, Piperidones, Piperazines;Piperidine;(intermediates of norastemizole hcl);Building Blocks;Heterocyclic Building Blocks;Piperidines
• Mol File: 58859-46-4.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 118-120 °C (5 mmHg)
• Flash Point: 173 °F
• Appearance: clear colorless to light yellow liquid
• Density: 1.004 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.0154mmHg at 25°C
• Refractive Index: n20/D 1.483(lit.)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• Solubility: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
• PKA: 10.09±0.20(Predicted)
• Water Solubility: >500 g/L (20 ºC)
• Sensitive: Air Sensitive
• BRN: 388597
• CAS DataBase Reference: Ethyl 4-amino-1-piperidinecarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: Ethyl 4-amino-1-piperidinecarboxylate(58859-46-4)
• EPA Substance Registry System: Ethyl 4-amino-1-piperidinecarboxylate(58859-46-4)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/38-36/37/38-22
• Safety Statements: 26-36
• WGK Germany: 3
• F: 2-10
• HazardClass: IRRITANT
• Hazardous Substances Data: 58859-46-4(Hazardous Substances Data)

Usage

Chemical Properties

clear colorless to light yellow liquid

Uses

Different sources of media describe the Uses of 58859-46-4 differently. You can refer to the following data:
1. Ethyl 4-amino-1-piperidinecarboxylate is a reagent used in various biosynthetic reactions.
2. Ethyl 4-amino-1-piperidinecarboxylate (1-Carbethoxy-4-aminopiperidine) was used in the synthesis of quinolin-2(1H )-one derivatives.

InChI:InChI=1/C8H16N2O2/c1-2-12-8(11)10-5-3-7(9)4-6-10/h7H,2-6,9H2,1H3/p+1

Upstream product

• 29976-53-2 N-ethoxycarbonyl-4-piperidone 

Downstream Products

• 618900-69-9 Ethyl 4-(3-nitropyridin-2-ylamino)piperidine-1-carboxylate 
• 100460-87-5 1-<(4-fluorophenyl)methyl>-benzimidazol-2(3H)-one 
• 84501-68-8 ethyl 4-[[1-[(4-fluorophenyl)methyl]-1H-benzimidazol-2-yl]amino]-1-piperidinecarboxylate 
• 73734-07-3 (1H-benzimidazol-2-yl)-(1-ethoxycarbonyl-piperidin-4-yl)amine 
• 416870-03-6 4-phenethylamino-piperidine-1-carboxylic acid ethyl ester 
• 107618-13-3 4-(4-Methoxy-2-nitro-phenylamino)-piperidine-1-carboxylic acid ethyl ester 
• 85443-52-3 ethyl 4-((2-nitrophenyl)amino)piperidine-1-carboxylate 
• 107618-15-5 4-(4,5-Dichloro-2-nitro-phenylamino)-piperidine-1-carboxylic acid ethyl ester 
• 85076-03-5 4-(5-chloro-2-nitro-phenylamino)-piperidine-1-carboxylic acid ethyl ester 
• 850697-57-3 ethyl 4-[(5-methyl-2-nitrophenyl)amino]-1-piperidinecarboxylate 
• 356072-51-0 1-Ethoxycarbonyl-4-[(2-methyl-6-nitrophenyl)amino]piperidine 
• 173843-49-7 ethyl 4-(4-methyl-2-nitroanilino)-1-piperidinecarboxylate 
• 850697-56-2 ethyl 4-[(5-fluoro-2-nitrophenyl)amino]-1-piperidinecarboxylate 
• 719268-05-0 ethyl 4-{[6-(2,6-difluorophenoxy)-8-methyl-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidin-2-yl]amino}piperidine-1-carboxylate 

Relevant articles and documents

Chemoselective reductive alkylation of ammonia with carbonyl compounds: Synthesis of primary and symmetrical secondary amines

An efficient, general procedure for highly chemoselective reductive mono-alkylation of ammonia with ketones is reported. Treatment of ketones with ammonia in ethanol and titanium(IV) isopropoxide, followed by in situ sodium borohydride reduction, and a straightforward workup afforded primary amines in good to excellent yields. Reductive alkylation of ammonia with aldehydes, on the other hand, afforded the corresponding symmetrical secondary amines selectively.

2-aminobenzoxazole derivatives and combinatorial libraries thereof

The present invention relates to novel 2-aminobenzoxazole derivative compounds of the following formula: wherein R1 to R4 and Z have the meanings provided herein. The invention further relates to combinatorial libraries containing two or more such compounds, as well as methods of preparing 2-aminobenzoxazole derivative compounds.

Method for synthesizing 2-substituted imidazoles

The present invention is a method of preparing 2-substituted imidazoles from readily available imidazoles having a leaving group in the 2-position, by alkylating the imidazole under mild conditions to afford a 3-N-alkylated imidazolium salt; and coupling the imidazolium salt with a nucleophile also under mild conditions to afford a 2-substituted 3-N-alkylated imidazolium salt. The reaction product can optionally be isolated and purified. The 2-substituted 3-N-alkylated imidazolium salt is hydrolyzed to afford a 2-substituted imidazole. Alternatively, the imidazole is coupled with a nucleophile in the presence of fluoride ion to provide a 2-substituted imidazole.