588688-44-2 Usage
Uses
Used in Pharmaceutical and Medicinal Applications:
3-Methyl-1H-indole-5-carboxylic acid is used as a pharmaceutical and medicinal compound for its potential anti-cancer and anti-inflammatory properties. Its unique structure allows it to interact with biological targets, offering a promising avenue for the development of new therapeutic agents.
Used in Organic Synthesis:
In the field of organic synthesis, 3-Methyl-1H-indole-5-carboxylic acid is used as a building block for the creation of various organic compounds. Its reactivity and functional groups make it a valuable component in the synthesis of complex molecules.
Used as a Reagent in Chemical Reactions:
3-Methyl-1H-indole-5-carboxylic acid also serves as a reagent in chemical reactions, facilitating the formation of desired products and aiding in the advancement of chemical processes.
Used as a Precursor in the Synthesis of Other Organic Compounds:
Furthermore, 3-Methyl-1H-indole-5-carboxylic acid is utilized as a precursor in the synthesis of other organic compounds, contributing to the diversity of chemical products and expanding the scope of chemical research and applications.
Check Digit Verification of cas no
The CAS Registry Mumber 588688-44-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 5,8,8,6,8 and 8 respectively; the second part has 2 digits, 4 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 588688-44:
(8*5)+(7*8)+(6*8)+(5*6)+(4*8)+(3*8)+(2*4)+(1*4)=242
242 % 10 = 2
So 588688-44-2 is a valid CAS Registry Number.
588688-44-2Relevant articles and documents
Regioselective hydroarylation reactions of C3 electrophilic N-acetylindoles activated by FeCl3: An entry to 3-(Hetero)arylindolines
Beaud, Rodolphe,Guillot, Regis,Kouklovsky, Cyrille,Vincent, Guillaume
supporting information, p. 7492 - 7500 (2014/06/23)
A method for the direct and rare umpolung of the 3 position of indoles is reported. The activation of N-acetylindole with iron(III) chloride allows the C-H addition of aromatic and heteroaromatic substrates to the C2-C3 double bond of the indole nucleus to generate a quaternary center at C3 and leads regioselectively to 3-arylindolines. Optimization, scope (50 examples), practicability (gram scale, air atmosphere, room temperature), and mechanistic insights of this process are presented. Synthetic transformations of the indoline products into drug-like compounds are also described.
Direct oxidative coupling of N-acetyl indoles and phenols for the synthesis of benzofuroindolines related to phalarine
Tomakinian, Terry,Guillot, Rgis,Kouklovsky, Cyrille,Vincent, Guillaume
supporting information, p. 11881 - 11885 (2015/01/09)
Inspired by the biogenetic synthesis of benzofuro-indoline-containing natural products, we designed an oxidative coupling between phenol and N-acetyl indoles. This straightforward and direct radical process, mediated by 2,3-dichloro-5,6-dicyano-1,4-benzoquinone and FeCl 3 allowed the regioselective synthesis of benzofuro[3,2-b]indolines, whose structure is found in the natural product phalarine.
