590366-68-0

Basic information

• Product Name: C₃₅H₆₀O₂Si₂
• Synonyms: C₃₅H₆₀O₂Si₂
• CAS NO: 590366-68-0
• Molecular Weight: 569.031
• Mol File: 590366-68-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: C₃₅H₆₀O₂Si₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₃₅H₆₀O₂Si₂(590366-68-0)
• EPA Substance Registry System: C₃₅H₆₀O₂Si₂(590366-68-0)

Safety Data

• Hazardous Substances Data: 590366-68-0(Hazardous Substances Data)

Upstream product

• 1246355-46-3 C₁₄H₂₀O 
• 81522-68-1 [(2Z)-2-[(3S,5R)-3,5-bis(tert-butyldimethylsilanyloxy)-2-methylenecyclohexylidene]ethyl]diphenylphosphine oxide 
• 112924-91-1 (5Z,7E)-(1S,3R,20S)-1,3-bis<(tert-butyldimethylsilyl)oxy>-9,10-seco-22,23-dinor-5,7,10(19)-cholatrien-24-al 
• 27491-70-9 dimethyl diazomethylphosphonate 

Downstream Products

• 590366-69-1 C₃₆H₆₀O₃Si₂ 
• 112965-21-6 calcipotriene 
• 112875-61-3 (1S,3R)-bis(tert-butyldimethylsilyloxy)-20(R)-(3'(S)-cyclopropyl-3'-hydroxyprop-1'(E)-enyl)-9,10-secopregna-5(Z),7(E),10⁽¹⁹⁾-triene 

Relevant articles and documents

Stereoselective synthesis of C24-hydroxylated vitamin D3 analogs: A practical and expeditius route to calcipotriol

The synthesis of the clinically important drug calcipotriol (2, MC903) is described as an example of a new and efficient approach to C24-hydroxylated analogs and metabolites of vitamin D3 (1). The key step of the process is the generation of the C24 stereocenter by DAIB [(-)-3-exo-(dimethylamino)isoborneol]-catalyzed addition of the alkenylzinc derivative of alkyne 3 to cyclopropylcarboxaldehyde.