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59045-98-6

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59045-98-6 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 59045-98-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,9,0,4 and 5 respectively; the second part has 2 digits, 9 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 59045-98:
(7*5)+(6*9)+(5*0)+(4*4)+(3*5)+(2*9)+(1*8)=146
146 % 10 = 6
So 59045-98-6 is a valid CAS Registry Number.

59045-98-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-(4-chlorophenyl)-N-pyridin-2-ylmethanimine

1.2 Other means of identification

Product number -
Other names 1H-Pyrrole-2-methanamine,N,N-dimethyl

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:59045-98-6 SDS

59045-98-6Relevant articles and documents

Annulation of Conjugated Azine-Imine with a Sulfoxonium Ylide in a Noncarbenoid Route to Synthesize Multisubstituted Imidazole-Fused Heterocycles

Guchhait, Sankar K.,Saini, Meenu,Khivsara, Viren J.,Giri, Santosh K.

, p. 5380 - 5387 (2021/05/05)

A new [4+1]-annulation of in situ generated heterocyclic azine-aldimines with β-keto sulfoxonium ylides has been developed. The reaction constructs N-fused imidazole rings. In the reaction, the ylides play a dual-functional role of a nucleophilic 1,1-dipo

The discovery of new and more potent chloropyramine (C4) analogues for the potential treatment of invasive breast cancer

Kandil, Sahar,Prencipe, Filippo,Jones, Samuel,Hiscox, Stephen,Westwell, Andrew D.

, p. 314 - 321 (2017/12/29)

Breast cancer is the second most common cancer worldwide, accounting for 25% of all female cancers. Although the survival rate has increased significantly in the past few decades, patients who develop secondary site metastasis as well as those diagnosed with triple negative breast cancer still represent a real unmet medical challenge. Previous studies have shown that chloropyramine (C4) inhibits FAK-VEGFR3 signalling. More recently, C4 is reported to have SASH1 inducing properties. However, C4 exerts its antitumour and antiangiogenic effects at high micromolar concentrations (>100?μm) that would not be compatible with further drug development against invasive breast cancer driven by FAK signalling. In this study, molecular modelling guided structural modifications have been introduced to the chloropyramine C4 scaffold to improve its activity in breast cancer cell lines. Seventeen compounds were designed and synthesized, and their antiproliferative activity was evaluated against three human breast cancer lines (MDA-MB-231, BT474 and T47D). Compound 5c was identified to display an average activity of IC50?=?23.5–31.3?μm, which represents a significant improvement of C4 activity in the same assay model. Molecular modelling and pharmacokinetic studies provided more promising insights into the mechanistic features of this new series.

Novel one-pot pseudo four component reaction: Expeditious synthesis of functionalized imidazo[1,2-a]pyridines

Sanaeishoar, Haleh,Nazarpour, Roya,Mohave, Fouad

, p. 68571 - 68578 (2015/09/01)

A new and efficient one-pot synthesis of imidazo[1,2-a]pyridines has been described. In this approach the installation of C-3 imine substituent on the imidazopyridine framework was developed. Corresponding products were prepared in mild conditions by reac

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